M.Sc. Nursing or Master of Science in Nursing is a Two-Year Postgraduate academic programme offered in different specialities. The aim of the programme is to prepare post graduates to assume responsibilities as nurse specialists, consultants, educators, administrators and researchers in a wide variety of professional settings. The programme is recognised by the Indian Nursing Council, Kerala Nurses' and Midwives’ Council and approved by Govt. of Kerala.

The College offers M. Sc. Nursing in four broad specialities (Medical-Surgical Nursing, Obstetric and Gynaecological Nursing, Child Health Nursing and Mental Health Nursing) with an annual intake of 36 students. Medical-Surgical Nursing is offered in four sub-specialities such as Cardiovascular & Thoracic Nursing, Oncology Nursing, Neurosciences Nursing and Nephro-Urology Nursing. Clinical experiences in all the specialities are provided in the parent hospital, Amrita Institute of Medical Sciences and Research Centre. Affiliation is taken from the National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore for clinical experience in Mental Health Nursing.

The clinical exposure in the respective speciality, classes taken by the clinicians and the nursing faculty, participation in various conferences, organising workshop on their own and the dissertation itself make each student's pathway to achieve the aims of the course.

Curriculum : As per Nursing Council of India and Amrita Vishwa Vidyapeetham (Deemed to be University)