Dr. Mark Walker
Title of the talk
Tomography of Salmonella in-vivo persistence during antimicrobial chemotherapy identifies actionable host contributions
Dr. Walker’s research focuses on the mechanism by which the group A streptococcus (Streptococcus pyogenes; GAS) causes invasive disease and GAS vaccine development. S. pyogenes is the etiologic agent of numerous suppurative diseases, ranging from mild skin infections such as pharyngitis, scarlet fever, impetigo and cellulitis, to severe invasive diseases such as septicemia, streptococcal toxic shock syndrome and necrotizing fasciitis. GAS is placed within the “top 10″ infectious disease causes of human deaths worldwide. Indigenous Australians suffer the highest rates of affliction with GAS diseases in the World. Of the over 100 M serotypes, the M1T1 clone which emerged in the mid-1980s and disseminated globally, causes most deaths and morbidity.