• Drug discovery is currently in an exciting phase where conventional methodologies are being ably complemented by ‘omics’ approaches due, in part, to the greater accessibility of the newest generation of high-throughput platforms and technologies. At the Cancer Discovery Biology Laboratory, work is done towards making the identification of oncology clinical biomarkers more feasible through state-of-the-art pharmacogenomic and proteomic techn

    cancer-discovery-biology
  • There are more than 2.5 million cancer patients in India at any given time, of which the frequency of breast and ovarian cancer cases has increased. Although there are many possible reasons, reversible phosphorylation of proteins, mediated by receptor tyrosine kinases (RTK) such as VEGF and HER2/neu receptors play a crucial role on different cellular processes associated with cancer pathogenesis.

    cancers-treated-with-vegf-and-her-2-neu-receptor-tyrosine-kinase-inhibitors
  • Application of nanomaterials to cell-based targeted diagnostics and regenerative medicine at a clinical level is an evolving domain that is of substantial interest to the medical scholars worldwide.

    cell-targeted-diagnostics-and-therapy-using-nanomaterials
  • This project deals with the development of a non-destructive technology for the detection of biological and chemical food toxins including bacteria, virus, small molecules toxins, and genetically modified foods using nanotechnology enabled Surface Enhanced Raman Scattering (SERS).

    chemical-and-biological-food-toxins-using-surface-enhanced-raman-scattering-sers-
  • This project proposes to explore the utility of the autologous modified endothelial cells engrafted onto a nano scaffold framework as a novel therapeutic modality for optimising wound healing. This would lead to potential translational application in patients with diabetic foot ulcers and non-healing wounds.

    development-of-blood-outgrowth-endothelial-cell-and-nanofiber-scaffold-synergy-in-wound-healing
  • Fusion transcripts are known to occur in cancerous cells across a range of cancers and might play important roles in the pathophysiology of cancer. In developing newer strategies to combat cancer, therapeutic knock down of fusion transcripts by RNA interference technology is being considered for its potential benefits in targeting cancerous cells.

    fusion-transcripts-in-cancer-and-the-potential-to-inhibit-by-rna-interference
  • Induced pluripotent stem cells (iPSc) are somatic cells that have been reprogrammed to a pluripotent state. These iPSc have similar characteristics to embryonic stem cells and hold great promise in various aspects of research. The aim of this study is to develop patient specific stem cells to understand disease mechanism and identify drugs that will prevent malignant transformation.

    generation-of-induced-pluripotent-stem-ips-cells-from-genetically-altered-somatic-cells
  • Multidrug resistant microbial infections are difficult to treat with common antibiotics, and incidences of infections caused by such strains are increasing day by day. Therefore, there is a constant and urgent need for alternative and effective anti-microbial agents for treatment of poultry, cattle and humans.

    identification-and-characterization-of-anti-microbial-compounds-s-and-adhesins-produced-by-lactobacillus-fermentum-l-fermentum-
  • Lactobacillus fermentum, a probiotic strain, which the team isolated from human colonic mucosal biopsy samples, possesses anti-microbial activities and inhibits the adhesion of enteropathogens to intestinal epithelial cells. Isolated cell surface associated proteins from L. fermentum were sufficient for this adhesion exclusion. Identification and characterisation of these surface proteins from L.

    identification-and-functional-analysis-of-probiotic-bacterial-surface-associated-proteins-in-preventing-enteropathogenic-infections
  • Rheumatoid arthritis is a chronic, progressive systemic inflammatory disease of the synovium, a delicate membrane that lines the non-weight-bearing surfaces of the joint. Auto-immunity plays an important role in the development of RA and that increased antibody response has been shown to be a hallmark of RA. Presence of anti-CCP and anti-immunoglobulin reactivity indicates that antibody response is crucial in the development of RA.

    identification-of-new-autoantigens-in-rheumatold-arthritis-using-an-unbiased-clinical-proteomics-approach
  • This project involves application of a new technique using a proteomics approach to sensitively identify molecules of therapeutic significance in Cerebral Spinal Fluid (CSF) samples.

    identification-of-novel-cell-surface-molecules-of-therapeutic-significance-in-central-nervous-system-leukemia
  • The Indo-Brazil Joint Workshop on Nanomaterials for Renewable Energy was held in Rio de Janeiro, Brazil. This workshop was led by Amrita Centre for Nanosciences. Indian participants were IIT Mumbai, IIT Delhi and Amrita Vishwa Vidyapeetham. There were 12 participants from various universities in Brazil. The workshop focused on research opportunities for collaboration between the two countries in renewable energy.

    indo-brazil-workshop-on-nanomaterials-for-renewable-energy
  • This project provides mobility funding for joint facility utilisation visits between ACNS and University of Zurich on the project entitled, “Anti-cancer Applications of Chitosan and Polyoxometalate Nanocomplexes”.

    joint-utilization-of-advance-facility-juaf-program-isjrp-indo-swiss
  • Metformin is a frequently used medication for patients with type II diabetes mellitus (DM) that has received increased attention, because of a study from pharmacy and disease databases showing decreased cancer incidence in individuals taking metformin. Metformin inhibits the growth of breast and prostate cancer cell lines. 

    metformin-encapsulated-biodegradable-chitosan-nanoparticles-a-novel-strategy-for-pancreatic-cancer-therapy
  • The project proposes to extend the nano-toxicological investigations of developed multifunctional NPs. It aims to extend the previous study to develop new theragnostic nanomedicines.

    nano-toxicology-and-nano-medicine-phase-ii
  • Manganese dioxide (MnO2) is a technologically important material and has been extensively studied due to its potential uses in non-volatile memory devices, gas sensors and batteries. The construction of aligned ensembles of these metal oxide nanostructures as electrodes could advance their existing potential in supercapacitor applications.

    nano-fibre-scaffold-electrodes-based-on-mn02-and-polymer-carbon-composites-for-high-performance-storage-device
  • Several projects are focused on the development of nanomedicines for application in cancer therapeutics, drug delivery for infectious diseases and also for regeneration of tissues using nanostructured scaffolds. Some of the tissues studied are bone, cartilage, cardiac tissue, vascular tissue and liver tissue. A wide range of natural polymeric nanostructured materials and bioceramics are being investigated for such applications.

    nanomedicine-and-tissue-engineering
  • Endovascular stents, used commonly for the treatment of occlusive vascular diseases, have historically been manufactured using metals and metal composites. Although stents have reduced the restenosis rate from 40% to 20% compared to angioplasty alone, in-stent restenosis still remains a major limitation for this approach.

    nanosurface-engineering-of-bare-metallic-coronary-stents-for-combating-in-stent-restenosis
  • The project 'Oncogene Sensing and Finger Printing from Saliva Using Nanotechnology' deals with Raman spectroscopic detection of cancer biomarkers from human tissues and bio-fluids.

    oncogene-sensing-and-finger-printing-from-saliva-using-nanotechnology-enabled-using-raman-spectroscopy
  • Staphylococcus aureus is the commonly found bacteria in septic arthritis. Methicillin resistant S.aureus (MRSA) is the most common cause of community-onset adult septic arthritis. It has been documented that S.aureus cell surface associated components can induce sepsis, organ injury, and septic arthritis. 

    role-of-staphylococcal-pathogen-associated-molecular-patterns-in-septic-arthritis
  • This project deals with development of nanomedicine for the targeted photodynamic therapy of cancer. This project is done in collaboration with Erasmus Medical Centre, Netherlands, where pre-clinical evaluation will be done using the nanomedicine developed by the ACNS team.

    targeted-nanoparticle-photodynamic-therapy
  • In 2011, Amrita Center for Nanosciences and Molecular Medicine was chosen for a TUE in Tissue Engineering and Medical Bio Nanotechnology by the Nanomission of the Government of India. The TUE focuses on translational biomedical products where nanomaterials play an enabling role. This includes nanomedicines using organic non-toxic encapsulants, surface modified products, multifunctional diagnostic nanoparticles, and tissue engineered implants.

    thematic-unit-of-excellence-tue-on-tissue-engineering-and-medical-bio-nanotechnology
  • The major research objective of this unit/centre is the development of theragnostic nanoparticles with multi-functionality and characterisation of these theragnostic materials through preclinical trials.

    theragnostics-re-generative-medicine-and-stem-cell-using-cell-targeted-nano-material
  • This project deals with nano-toxicological evaluation of silica nano-particle based agricultural products such as neutraceuticals and pesticides.

    toxicology