• An innovative green technology for treating municipal and industrial wastewater entering rivers and streams

    This research project seeks to bring together biomass based biochars and hydrochars from rice husk waste product to remove heavy metals and other contaminants from industrial and domestic wastewater that makes its way untreated or only partially treated into rivers and streams.

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  • Antimicrobial Textiles Using Phage and Other Lytic Agents

    Antimicrobial textiles is of high market value for their potential use in different sanitary causes such as hospital clothes, bed linens, wound healing bandage, sanitary napkins etc. We checked the literature to find out the possible solutions in this regard which ranged from impregnation of the textile material with natural products, dyes and nanomaterials. They are generally costly and very often ineffective against antibiotic resistant infections.

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  • C. elegans as a Model to Develop Anti-helmintic Strategies in Solid Waste Management

    Caenorhabditis elegans is a widely used model nematode for developing anti-helmintic drugs. We have used that for developing safe waste management strategy against soil transmitted helminthes contributing most significantly to global burden of infection. Sludge accumulation is the major problem in various parts of the world. Composting can be a cost-effective solution and can be potentially augmented with inherent sewage lytic agents.

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  • Characterization of the fibronectin isoforms and its fragments

    Characterization of Fibronectin isoforms and proteolytic fragments affecting cell behaviour (cell morphology, migration, proliferation)

    Factors affecting gelatinase (MMP-2) mediated fragmentation of fibronectin

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  • Development of Heterotrophic and Phototrophic Microbial Fuel Cell

    Apart from the various alternatives of conventional energy sources, electricity generated by microorganisms can be an important source of renewable energy. The Microbial Fuel Cell (MFC) which harnesses this potential, offers possibilities of extracting energy from a wide range of substrates from complex organic wastes to inorganic carbon dioxide.

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  • Expression of Recombinant Enzymes Against Enteric pathogens

    Enteric pathogens in the sewage are the reason for a variety of diseases throughout the world. Here in this project we use recombinant protein expression as a remedy to kill enteric pathogens present in sewage. One way to kill these pathogens is by degrading their cell walls using cell wall hydrolases like amidase. We isolated the plasmid from the transformed S. aureus with the pTX15 vector containing the amidase, using Qiagen plasmid isolation kit.

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  • Matrix Binding microbes and bacteriophages to counter infection

    Matrix binding proteins from probiotics and viruses:

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  • Screening for Compounds with Lifespan Altering Effect on Caenorhabditis Elegans and Gene Expression Microarray Data Based Computational Drug Repurposing

    Lifespan is a biological process regulated by several genetic pathways. One strategy to investigate the regulation of lifespan is to use small molecules to perturb age-regulatory pathways. Here we plan to screen compounds in a biphasic approach. To find compounds that extend and decrease lifespan of C. elegans. To date, a number of molecules are known to extend or decrease lifespan in various model organisms and are used as tools to study the biology of aging and anthelminthic.

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  • Studies On Antagonistic Effects Of Partially Purified Bacteriocins From Microflora Of Fermented Vegetables Against Enteric Pathogens

    Bacteriocins are antimicrobial peptides produced by bacteria that kill or inhibit the growth of other bacteria. Bacteriocins differ from most therapeutic antibiotics in being proteinaceous and generally express a narrow specificity of action against strains of the same or closely related species.

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  • Synergistic Effects of Plants and Bacteriophages in Wastewater treatment

    Plants are widely used for wastewater treatment, but there are concerns that the plants might act as a reservoir of the pathogens. This project aims at using bacteriophages to specifically kill the pathogenic bacteria and use the roots of the aquatic plants as possible adsorbent material for bacteriophages.

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  • Viral agents to target and kill pathogens and odour-producing bacteria in fecal waste

    Viruses infecting the bacteria, called bacteriophage (phage), have been used for over 90 years as an alternative to antibiotics in Russia, east Europe and France.  They are currently being tried as a possible therapy against multi-drug-resistant strains of many bacteria. We are looking for potential application of bacteriophages and their parts or enzymes from kitchen waste in treating enteric infections and foul smell from domestic wastewater (toilet).

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