Anacardic acid - a novel template for cancer therapy

Traditional Indian medicine has always captivated Indian researchers and medical practitioners for its application in various pathological conditions. Natural products have been an invaluable repository for the discovery of novel drug candidates as a source of remedy for a number of ailments including cardiovascular diseases and cancers. Almost 60% of the approved anti-cancer drugs were known to be derived from natural sources.

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Cyclooxygenase-2 in Cancer and Inflammatory Diseases

Cancer, which results from altered tissue growth regulation, is one of the leading causes of death worldwide.  Inflammation is the response of the immune system to infection and injury and has been implicated in the pathogeneses of arthritis and cancer. There are several interactions that occur within the tumor microenvironment that is dependent on various signaling pathways.

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Development of a Lab-on-a-Chip (LoC) for detection of Glucose, Cholesterol and Kidney Function

The proposed work involves the fabrication of lab-on-a-chip (LOC) diagnostic device that incorporates non-enzymatic sensors for detection of glucose, cholesterol and creatinine. The device consists of a disposable microfluidic component that houses the sensors and a non disposable electronics module.

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Development of Non-enzymatic Electrochemical Glucose Biosensors and Glucometer

Diabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme based and has numerous drawbacks including high cost and insufficient long-term stability, both of which originate from the intrinsic nature of the enzymes. This project aims at developing a commercially viable non-enzymatic glucose sensor strip and a glucometer. Electrode surface modified with transition metal and metal oxide nanoparticles have been used for the development of non-enzymatic sensors for the amperometric measurements of glucose. 

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Elucidating the Molecular Mechanisms of Anacardic Acid and Biacacetin Mediated Regulation of Matrix Metalloproteinases in Cancer

Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries like India. An in-depth understanding of the molecular mechanisms involved in the progression of different forms of cancer has been the focus of drug discovery efforts.

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Identification of Molecular Mechanisms of Action of the Cardioprotective Compound Arjunolic Acid

Anthracyclines are among the most effective anti-cancer treatments ever developed, but their clinical use is limited by their cumulative dose-related cardio-toxicity which may ultimately lead to a severe form of cardiomyopathy. A classical example is Doxorubicin (DOX) that is used for the treatment of a wide variety of cancers, including lymphoma, leukemia, and solid tumors.

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Identification of Natural Product Lead molecules as Potential Modulators of Wound Healing and Elucidation of the underlying Molecular Mechanisms

Wound healing is the result of a complex interplay between various cell types wherein macrophages and fibroblasts play a crucial role during various phases of the process.

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Isolation and Characterization of Primary Tumor Cells

 The lack of effective “in vitro” models to predict success of pharmacological therapy for patients with variety of cancer cell types demands the development of better experimental models to understand the pathophysiology of the disease and evaluate drug sensitivity in vitro. Cell lines are well characterized homogenous population that gives consistent and reproducible result from experiment to experiment. Many of these cell lines were established over 20 years ago.

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Low Cost Device and Cloud Enabled Smart Solution for Diabetes Care

In a unique partnership, Amrita Vishwa Vidyapeetham joined hands with Wipro Technologies, Bangalore to work on an end-to-end diabetes solution. The project entitled "Low Cost Device and Cloud Enabled Smart Solution for Diabetes Care" is funded by DBT-BIRAC, Government of India.

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Quorum Sensing and Biofilm Formation in Microbial Pathogenesis

When encountering a new host, every potential microbial pathogen can stay, acquire nutrients, colonize and then seek another host.  Alternatively the pathogen could express its full battery of virulence factors, and invade the host. The successful attack of a host is now understood to be a communal process called Quorum Sensing (QS).

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Regulation of Inflammation by Natural Product extracts: Role in osteoclastogenesis

Inflammation is the body's endeavor at self-defense, the intent being to eradicate harmful stimuli, including damaged cells, irritants, or pathogens and begin the healing process.  It is one of the major steps in normal wound healing process with overlapping events such as formation of granulation tissue, angiogenesis, and tissue remodeling. However, chronic inflammation can also lead to a host of diseases.

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Role of miRNAs in cancer and modulation of oncogenes by natural products

Cancer known medically as a malignant neoplasm, is a broad group of diseases involving unregulated cell growth. Understanding the mis-regulation of molecular mechanisms leading to cancer has been the primary method of discovering new drug targets. MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis.

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Screening for Compounds with Lifespan Altering Effect on Caenorhabditis Elegans and Gene Expression Microarray Data Based Computational Drug Repurposing

Lifespan is a biological process regulated by several genetic pathways. One strategy to investigate the regulation of lifespan is to use small molecules to perturb age-regulatory pathways. Here we plan to screen compounds in a biphasic approach. To find compounds that extend and decrease lifespan of C. elegans. To date, a number of molecules are known to extend or decrease lifespan in various model organisms and are used as tools to study the biology of aging and anthelminthic.

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