Our lab is currently focused on the identification and characterization of Natural Product Lead molecules and understanding their role in:

  • Regulating Matrix Metalloproteinases and oncogenic signaling systems
  • Modulating the complex processes involved in wound healing
  • Pathogenesis and virulence with specific emphasis on Quorum Sensing
  • Cardio-protection to enable their use in combination therapies
  • Regulating Inflammasomes and the inflammatory signaling cascades in disease states
     

Our current research focuses on the Development of Low cost Biomedical Devices and Diagnostics for the management of Diabetes & Identification of Natural Product Lead molecules as Potential Modulators and Elucidation of Molecular Mechanisms Involved in Impaired Wound Healing in Diabetes.

amrita-center-research-cell-biology-research-imgResearch Interests

  • Identification of Natural Product Lead molecules as Potential Modulators of Wound Healing and Elucidation of the molecular mechanisms involving Nitric Oxide and Epidermal Growth Factor in the wound healing process.
  • Understanding the regulation of Matrix Metalloproteinases (MMP) and oncogenic signaling systems by Natural Products and dissecting the regulatory crosstalk between MMP-2, MMP-14 and TIMP-2.
  • Natural product lead discovery employing Quantitative Structure Activity Relationship (QSAR) studies with MMP modulators.
  • To study the role of quorum sensing and biofilm formation in microbial pathogenesis and identification of natural product inhibitors that inhibit this process.
  • Understanding the molecular mechanisms of inflammasome complex in regulating inflammatory signaling cascade and to identify natural product inhibitors that modulate the process. 
  • To elucidate the role of miRNAs and natural products that specifically target cyclooxygenase (COX-2) gene expression and activity in cancer and inflammation.
  • Identification of novel regulatory mechanisms of oncogenes and tumor suppressors mediated by miRNAs. 
  • To elucidate the prominent molecular mechanisms of cardio-protection elicited by Arjunolic Acid against Doxorubicin-induced cardiotoxicity.
  • Development of low cost Biomedical Devices and Diagnostics for the management of Diabetes.

 

Projects

Identification of Natural Product Lead Molecules as Modulators of Wound Healing

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Wound healing is the result of a complex interplay between various cell types wherein macrophages and fibroblasts play a crucial role during various phases of the process... Read More»

Anacardic Acid - a Novel Template for Cancer Therapy

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Traditional Indian medicine has always captivated Indian researchers and medical practitioners for its application in various pathological conditions.... Read More»

Elucidating the Molecular Mechanisms of Anacardic Acid Mediated Regulation of Matrix Metalloproteinases in Cancer

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Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries like India. ... Read More»

Role of Natural Products in Regulating Inflammasome Signaling Cascade and Potential Effect

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Inflammation is the body's endeavor at self-defense, the intent being to eradicate harmful stimuli, including damaged cells, irritants, or pathogens and begin the healing process.... Read More»

Quorom Sensing and Microbial Pathogenesis

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When encountering a new host, every potential microbial pathogen can stay, acquire nutrients, colonize and then seek another host. Alternatively the pathogen could express.... Read More»

Identification of Molecular Mechanisms of Action of the Cardioprotective Compound Arjunolic Acid

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Cancer is the leading cause of death in economically developed countries and the second leading cause of death in developing countries like India. ... Read More»

Cyclooxygenase-2 in Cancer and Inflammatory Diseases

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Cancer, which results from altered tissue growth regulation, is one of the leading causes of death worldwide. Inflammation is the response of the immune system to infection and injury... Read More»

Role of miRNAs in cancer and modulation of oncogenes by natural products

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Cancer known medically as a malignant neoplasm, is a broad group of diseases involving unregulated cell growth. Understanding the mis-regulation.... Read More»

Development of a Non-enzymatic Glucose Sensor and Glucometer

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Diabetes mellitus is a public health problem affecting millions of people worldwide. Commercially available glucose sensors are enzyme... Read More»

Development of a Lab-on-a-Chip (LoC) for detection of Glucose, Cholesterol and Kidney Function

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The proposed work involves the fabrication of lab-on-a-chip (LOC) diagnostic device that incorporates non-enzymatic sensors for detection of glucose, cholesterol and creatinine... Read More»

Low Cost Device and Cloud Enabled Smart Solution for Diabetes Care

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In a unique partnership, Amrita University joined hands with Wipro Technologies, Bangalore to work on an end-to-end diabetes solution. The project entitled "Low Cost Device and Cloud... Read More»

Regulation of Inflammation by Natural Product Extracts: Role in Osteoclastogenesis

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Inflammation is the body's endeavor at self-defense, the intent being to eradicate harmful stimuli, including damaged cells, irritants, or pathogens and begin the healing process... Read More»

Isolation and Characterization of Primary Tumor Cells

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The lack of effective “in vitro” models to predict success of pharmacological therapy for patients with variety of cancer cell types demands the development of better experimental models... Read More»