Medicinal Chemistry: Introduction, drugs - classification of drugs - mechanism of drug action. Drug-receptor complex nomenclature - agonist, antagonist.
Physicochemical properties in relation to biological action: solubility, partition coefficient, dissociation constant, hydrogen bonding, ionization, drug shape, surface activity, complexation, protein binding, molar refractivity, bioisosterism - Stereo chemical aspects of drug action-stereo isomerism-optical isomerism.
Enzymes and hormones: Enzymes - nomenclature, classification and characteristics of enzymes - mechanism of enzyme action, factors affecting enzyme action, cofactors and co-enzymes, enzyme inhibition, enzymes in organic synthesis. Hormones and vitamins - representative cases.
Medicinal agents from natural products: Natural products as therapeutic agents, medicinal plants, animal products as medicine, isolation methods of alkaloids, terpenes, anti-oxidants.
Medicinal agents: Medicinal agents belonging to steroids, polypeptides, modified nucleic acid bases, sulphonamide and sulpha drugs, antibiotics, antifungal, antiseptics and disinfectants, anaesthetics, antihypertensive drugs, analgesics, histamine and anti-histamine agents.