Dr. Sonali Bhattacharjee visited Amrita Vishwa Vidyapeetham and gave a talk on "Investigating the Nexus between DNA Repair Pathways and Genomic Instability in Cancer", on January 10, 2018.
Synthetic lethality refers to a lethal phenotype that results from the simultaneous disruptions of two genes, while the disruption of either gene alone is viable.
Many DNA double strand break repair genes have synthetic lethal relationships with oncogenes and tumor suppressor genes which can be exploited for targeted cancer therapy, an approach referred to as combination therapy.
DNA double-strand breaks are one of the most toxic lesions to a cell and can be repaired by non-homologous end joining or homologous recombination.
HR and NHEJ genes are particularly attractive targets for cancer therapy because these genes have altered expression patterns in cancer cells when compared with normal cells and these genetic abnormalities can be targeted for selectively killing cancer cells.
In her presentation, Dr. Sonali Bhattacharjee summarized recent progress in understanding both the functioning and the regulation of the DNA repair machinery and scrutinized the clinical applications of these proteins in cancer therapy.