Dr. Sonali Bhattacharjee visited Amrita Vishwa Vidyapeetham and gave a talk on "Investigating the Nexus between DNA Repair Pathways and Genomic Instability in Cancer", on January 10, 2018.

Synthetic lethality refers to a lethal phenotype that results from the simultaneous disruptions of two genes, while the disruption of either gene alone is viable.

Many DNA double strand break repair genes have synthetic lethal relationships with oncogenes and tumor suppressor genes which can be exploited for targeted cancer therapy, an approach referred to as combination therapy.

DNA double-strand breaks are one of the most toxic lesions to a cell and can be repaired by non-homologous end joining or homologous recombination.

HR and NHEJ genes are particularly attractive targets for cancer therapy because these genes have altered expression patterns in cancer cells when compared with normal cells and these genetic abnormalities can be targeted for selectively killing cancer cells.

In her presentation, Dr. Sonali Bhattacharjee summarized recent progress in understanding both the functioning and the regulation of the DNA repair machinery and scrutinized the clinical applications of these proteins in cancer therapy.


Dr. Sonali Bhattacharjee is a scientist with 10+ years of experience in oncology with a focus on identifying targets for cancer therapy. Some of the highlights of her career:

  • Published several research articles in highly reputed scientific journals
  • Recipient of the prestigious K.Pathak Clarendon scholar for D.Phil. (PhD) studies in Biochemistry from Oxford University, UK and is a postdoctoral scientist at CSHL, a preeminent international research institution
  • Partners for Future Mentor at CSHL where local junior high students are trained in laboratory research to give them a taste of the real world of biomedical research.
  • Academic Tutor Watson School of Biological Sciences, CSHL where I tutor courses on Scientific Reasoning and Logic module on Gene Expression for graduate students.
  • Peer-reviewer for several international journals including PLOS ONE and Nutrients (MDPI)
  • Elected member of Postdoc Liaison Committee (PDLC): Facilitate communication between postdoctoral fellows and CSHL leadership to discuss postdoctoral affairs and generally work to improve the postdoctoral experience in the laboratory.
  • Multilingual, lived & worked in three different continents, possess a life experience to adapt to new challenges in a stimulating environment.

Dr. Sonali Bhattacharjee

Event Details
Date: 
2018-01-10 10:00 to 11:00
ORGANIZED BY:
Center: 
International Programs