M. Pharm., B. Pham.

Anu Priya joined as Lecturer in Department of Pharmaceutics, Amrita School of Pharmacy in September 2015. She has 1 year experience in research at Sree Chitra Tirunal Institute of Science and Technology, Thiruvananthapuram and 2 years industrial experience in QA and RA department of Microlabs Bangalore, Sance Laboratories Pala. She has completed M. Pharm. from Nehru College of Pharmacy, Pampady, Kerala Univeristy and B. Pharm. from St. Joseph’s College of Pharmacy, Cherthala, Kerala University. Her research interest is Advanced Drug Delivery System.


Publication Type: Journal Article

Year of Publication Title


R. Jayaprakash, Hameed, J., and Anupriya, “An overview of transdermal delivery system”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 36-40, 2017.[Abstract]

Recently, most widely using conventional dosage form such as tablet, capsules, and injections but due to some case we are preferable to choose transdermal drug delivery system (TDDS) because conventional oral dosage form undergo first pass metabolism. In TDDS, skin is the effective medium for the penetration of drug into systemic circulation. This system required very low dose for the effective result or action. One of the major disadvantages of TDDS is penetration rate is very low through the stratum corneum. Nowadays, different types of skin penetration enhancement techniques are used for increasing the penetration. These types of techniques can be also increase the bioavailability. The patients have more preferable to choose this type of drug delivery system because it has more advantages than conventional dosage form. This article is discuses about the anatomy and physiology of skin and its drug penetration capacity, polymers used in transdermal drug delivery and different types of TDDS. © 2017 The Authors. More »»


N. Lopez, Athira, P. N., Ajeesh, P., Nair, A. S., Ankitha, L., and Anupriya, “Pharmacology and bio-medicinal properties of chitin and its derivative”, Journal of Pharmaceutical Sciences and Research, vol. 9, pp. 857-859, 2017.[Abstract]

Crabs are decapod crustaceans belonging to the infra order brachyura. They covered by exoskeleton having many pharmacological properties. This review shows about many properties of crab and chitin (exoskeleton).crab meat consist of omega 3 a polyunsaturated acid which provide protection against heart diseases. Selenium provides anti-oxidant properties. Riboflavin helps in the production of steroids and RBC’S. Skin maintenance, normal growth iron absorption and support anti- oxidant properties. copper and phosphate contained in the crab helps in the absorption, storage and metabolism of iron. Crab is used to reduce BP, psoriasis etc. Cluster of crab has application in food and medical field, agriculture, aquaculture, cosmetics and waste water and membranes. Chitin of crab is having anti-inflammatory properties and it is found that chitin is a size dependent regulator of inflammation. chitosan oligosaccharides reducing inflammation by inhibiting TNF- α in LPS stimulated inflammation. Chitin is having anti proliferative effects and it is useful for anticancer chemotherapy with decreased side effects and gradual release of drugs to cancerous cell, it can fights against several pathogenic organisms such as fungi, bacteria, yeast by its antimicrobial effect. It is observed that chitin and its derivatives are one among the powerful anti-diabetic agent, which has less side effects. Chitin can be used as anti-angiogenic agent in the formation of cancer cells. chitin also include wound healing and anti-inflammatory property. © 2017, Pharmainfo Publications. All rights reserved.

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S. Murali, 2, NAIR, S. R. E. E. J. A. C., and Anupriya, “Drug delivery research: Current status and future prospects”, Int J Pharm Sci Rev Res , vol. 40, no. 1, pp. 94-99, 2016.[Abstract]

Nowadays the development of new drug delivery systems plays a major role in pharmaceutical industries. The drug delivery practice has been altered in last years and even many advanced innovations happened in recent times. Newer drug delivery technologies are largely influencing the current medical practice. Alterations of a current drug into a new drug delivery technology can positively changing the bioavailability, safety and efficacy of the drug and also it can produce improved patient compliance. At this time, a number of pharmaceutical companies are forwarded to initializing multiple drug delivery technologies for creating excellent advantages, prolonging patent and better outcome for their marketed products. One of the main challenges in newer drug delivery is, huge molecules are rapidly dissolved in the blood volume and they have a lined capacity to cross barriers. Drug delivery technologies can be performed on many available dosage forms like tablets, capsules, pills, injections, suppositories etc. Conventional drug delivery may produce problems regarding oral bioavailability. This can be improved by introducing newer drug delivery techniques like oral controlled drug delivery, site targeted delivery, rate programmed drug delivery, feedback regulated delivery, fastly disintegrating dosage form by oral route, topical and nasopulmonary drug delivery

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K. Ramesh, Krishnapriya, M., Anupriya, and Nair, S. C., “An outlook to non-pharmacological and novel approaches to combat the uncurable firing disorder”, International Journal of Pharmaceutical Sciences Review and Research, vol. 40, pp. 55-61, 2016.[Abstract]

Epilepsy, a serious neurological abnormality which exhibit neuronal misfiring and send out of incorrect signals as its major characters which ultimately lead to seizures. The etiological factors of seizures vary widely ranging from Hypoxia to brain tissues, infection or injury to brain tissues and also certain inborn defects, stress, consumption of illicit drugs, withdrawal of alcohol and the current therapy cannot completely cure epilepsy. Drug resistant epilepsy (also known as pharmaco resistant epilepsy) is a chronic, life threatening condition that affect the quality of life and ultimately lead to death of the patient. The concentration related peripheral side effects of antiepileptic medications remains a major challenge to the researchers. Prevention of epilepsy can be done in 60% of the cases by the use of AEDs but the Non-conventional therapy helps in symptomatic relief and seizure frequency reduction especially in case of refractory or drug resistant epilepsy. These treatments also play a role in preventing the toxicity problems of AEDs. This review mainly deals with the innovative strategies for the site specific therapeutic maintenance of drug in the epileptic focci and several methods to diagnose epilepsy. © 2016, Global Research Online. All rights reserved. More »»


K. Kamalasanan, Anupriya, Deepa, M. K., and Sharma, C. P., “Supramolecular curcumin–barium prodrugs for formulating with ceramic particles”, Colloids and Surfaces B: Biointerfaces, vol. 122, pp. 301 - 308, 2014.[Abstract]

Abstract A simple and stable curcumin–ceramic combined formulation was developed with an aim to improve curcumin stability and release profile in the presence of reactive ceramic particles for potential dental and orthopedic applications. For that, curcumin was complexed with barium (Ba2+) to prepare curcumin–barium (BaCur) complex. Upon removal of the unbound curcumin and Ba2+ by dialysis, a water-soluble BaCur complex was obtained. The complex was showing [M+1]+ peak at 10,000–20,000 with multiple fractionation peaks of MALDI-TOF-MS studies, showed that the complex was a supramolecular multimer. The 1H NMR and FTIR studies revealed that, divalent Ba2+ interacted predominantly through di-phenolic groups of curcumin to form an end-to-end complex resulted in supramolecular multimer. The overall crystallinity of the BaCur was lower than curcumin as per XRD analysis. The complexation of Ba2+ to curcumin did not degrade curcumin as per HPLC studies. The fluorescence spectrum was blue shifted upon Ba2+ complexation with curcumin. Monodisperse nanoparticles with size less than 200dnm was formed, out of the supramolecular complex upon dialysis, as per DLS, and upon loading into pluronic micelles the size was remaining in similar order of magnitude as per DLS and AFM studies. Stability of the curcumin was improved greater than 50% after complexation with Ba2+ as per UV/Vis spectroscopy. Loading of the supramloecular nanoparticles into pluronic micelles had further improved the stability of curcumin to approx. 70% in water. These BaCur supramolecule nanoparticles can be considered as a new class of prodrugs with improved solubility and stability. Subsequently, ceramic nanoparticles with varying chemical composition were prepared for changing the material surface reactivity in terms of the increase in, degradability, surface pH and protein adsorption. Further, these ceramic particles were combined with curcumin prodrug formulations and optimized the curcumin release properties in the combined formulations. Our proof concept study shows that, the conversion of curcumin to a metal-organic supramolecular prodrug improved the solubility, stability and release profile of curcumin. The prodrug approach with the micellisation strategy appears to be more appropriate to deliver intact curcumin in the presence of ceramic particles of varying surface reactivity.

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