Qualification: 
MSc, BSc
archanapv@am.amrita.edu
Phone: 
+91 9656419809

Archana P. V. currently serves as a Junior Research Fellow at Amrita School of Biotechnology. She received her M.Sc in Microbiology from Amrita Vishwa Vidyapeetham in 2015.

ALMA MATER

  • M.Sc Biotechnology, Amrita Vishwa Vidyapeetham (2015)
  • B.Sc Biotechnology, Amrita Vishwa Vidyapeetham (2010)

AWARDS /HONORS

  • Selected as Khorana Scholar 2014 worked on “Expression of MP1 protein in the MCF 7 cells and their effect on mobility and invasion.” with Dr. Susan E. Conrad, Michigan State University, US.
     

RESEARCH EXPERIANCE

  • Six months project on “Studies of probiotic strains from fermented foods and beverages in Kerala” with Dr. Sanjay Pal and Dr Nandita Mishra at Amrita School of Biotechnology, Amritapuri, Kollam.
  • Ten weeks internship on “Expression of MP1 protein in the MCF 7 cells and their effect on mobility and invasion” with Dr. Susan E Conrad at Michigan State University, Michigan, USA as a part of Khorana Scholarship 2014.
  • Six months project on “Biophysical characterization of ZnO Nanoparticles and its Bio-modification for improved cellular delivery”, with Dr. Munia Ganguli at CSIR-Institute of Genomics and Integrative Biology, Delhi.
     

ONGOING RESEARCH PROJECT 

Isolating heliminths and protists from different sources and screening compounds against the same.

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2017

Journal Article

Chandni P, Amrita Salim, Archana P. V., Pradeesh Babu, Dr. Bipin G. Nair, Madhavan, A., and Dr. Sanjay Pal, “Characterization of the bacteriophages binding to human matrix molecules.”, International Journal of Biological Macromolecules, 2017.[Abstract]


Recent literature has suggested a novel symbiotic relationship between bacteriophage and metazoan host that provides antimicrobial defense protecting mucosal surface by binding to host matrix mucin glycoproteins. Here, we isolated and studied different bacteriophages that specifically interact with human extracellular matrix molecules such as fibronectin, gelatin, heparin and demonstrated their potency for protection to host against microbial infections. We showed that subpopulations of bacteriophages that work against clinical isolates of Escherichia coli can bind to pure gelatin, fibronectin and heparin and reduced bacterial load in human colon cell line HT29. The bacteriophages were characterized with respect to their genome sizes, melting curve patterns and host tropism (cross-reactivity with different hosts). Since, the bacteriophages are non-toxic to the host and can effectively reduce bacterial load in HT29 cell line their therapeutic potency against bacterial infection could be explored.

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