Research Interests

In India, envenomation by members of the four major venomous snakes species, spectacled cobra (Naja naja), common krait (Bungarus caeruleus) saw scaled viper (Echis carinatus) and Russell's viper (Daboia russelii,) leads to about 12,000 death per year that are clinically recorded and an estimated number of 46,000 death per year over all. A large proportion of the bites and deaths are thought to go unrecorded because they occur in rural areas among poorer segments of the population where timely and effective antivenom treatments are either not available or too expensive. 

Antibody based antivenom preparations have two major sources of variability, variability of the venom source used for immunization and variability in the immune response of the animal to be immunized. Furthermore, antibody based antivenom may also elicit serious immune reactions and complications in the recipient since they are usually derived from a heterologous species.

With this in mind, we decided to develop alternative approaches to antivenom production in which individual venom components are first isolated and then individually targeted for inhibition using either random peptide libraries or potential small molecules available. Once good inhibitors have been developed for the relevant toxin componenets, these can then be combined and tested for their ability to neutralize the venom in in vivo models.

Publications

Publication Type: Conference Proceedings
Year of Publication Publication Type Title
2013 Conference Proceedings A. Alangode, Reick, M., Reick, M., and Nair., B., “Natural Product Mediated Modulation of a Russell's Viper Metalloprotease Fibrinogenolytic Activity”, Elsevier Publications. 2013.
Publication Type: Journal Article
Year of Publication Publication Type Title
2003 Journal Article C. A. Dudley, Erbel-Sieler, C., Estill, S. Jo, Reick, M., Franken, P., Pitts, S. N., and McKnight, S. L., “Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice”, Science, vol. 301, pp. 379–383, 2003.
2002 Journal Article J. Rutter, Reick, M., and McKnight, S. L., “Metabolism and the control of circadian rhythms”, Annual review of biochemistry, vol. 71, pp. 307–331, 2002.
2002 Journal Article J. Shepard, Reick, M., Olson, S., and Graveley, B. R., “Characterization of U2AF6, a splicing factor related to U2AF35”, Molecular and cellular biology, vol. 22, pp. 221–230, 2002.
2001 Journal Article M. Reick, Garcia, J. A., Dudley, C., and McKnight, S. L., “NPAS2: an analog of clock operative in the mammalian forebrain”, Science, vol. 293, pp. 506–509, 2001.
2001 Journal Article J. Rutter, Reick, M., Wu, L. C., and McKnight, S. L., “Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors”, Science, vol. 293, pp. 510–514, 2001.
2000 Journal Article J. A. Garcia, Zhang, D., Estill, S. Jo, Michnoff, C., Rutter, J., Reick, M., Scott, K., Diaz-Arrastia, R., and McKnight, S. L., “Impaired cued and contextual memory in NPAS2-deficient mice”, Science, vol. 288, pp. 2226–2230, 2000.
1994 Journal Article M. Reick, Robertson, R. W., Pasco, D. S., and Fagan, J. B., “Down-regulation of nuclear aryl hydrocarbon receptor DNA-binding and transactivation functions: requirement for a labile or inducible factor.”, Molecular and cellular biology, vol. 14, pp. 5653–5660, 1994.
Faculty Details

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Faculty Email: 
martin@am.amrita.edu