Dr. Sabitha M. joined Amrita School of Pharmacy in March 2000. She completed her Bachelor's Degree in Pharmacy from St. John's Pharmacy college, Bangalore University and her Master's Degree in Pharmaceutics from Dr. Harisingh Gour Vishwavidyalaya, Sagar, M.P. (1999). She completed her Ph.D in Pharmaceutical Sciences from Amrita Vishwa Vidyapeetham University in 2012. Her doctoral dissertation was titled "Chitin Nanogels as an Effective Nanocarrier for the Treatment of Melanoma via the Transdermal Route". She served as the Vice Principal of the School during the period February 2008 - September 2011. She has 13 years of teaching and research experience and has several publications in national and international journals.

During July-August 2010, she received one-month advanced training in the practice of clinical pharmacy at the University of Michigan, College of Pharmacy, United States. Dr. Sabitha's current research focuses on transdermal drug delivery and colon specific drug delivery. Other areas of interests include nanogel formulations and enhancement of bioavailability.


Publication Type: Journal Article
Year of Publication Publication Type Title
2016 Journal Article V. Dhanalakshmi, Nimal, T. R., Sabitha, M., R.a Biswas, and Jayakumar, R., “Skin and muscle permeating antibacterial nanoparticles for treating Staphylococcus aureus infected wounds”, Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2016.[Abstract]

Majority of the chronic wounds are infected with bacteria like Staphylococcus aureus (S. aureus). The deep tissue infections are difficult to treat using topical antibiotics, due to their poor tissue penetration. In order to treat S. aureus deep tissue infections we have developed an antibiotic delivery system using chitosan nanoparticles (CNPs). To enhance their tissue penetration these CNPs were further coated using lecithin (CLNPs). Antibiotic tigecycline was loaded into chitosan nanoparticles (tCNPs) and then coated with lecithin to generate lecithin coated tigecycline loaded chitosan nanoparticles (tCLNPs). The prepared nanoparticles were characterized using DLS, SEM, TEM and FT-IR. The prepared CNPs, tCNPs, CLNPs and tCLNPs have the size range of 85±10, 90±18, 188±5 and 235±20 nm, respectively. The tCLNPs shows more sustained release pattern of tigecycline. The antibacterial activity of the developed nanoparticles was confirmed against laboratory and clinical strains of S. aureus using in vitro and ex vivo experiments. The ex vivo skin and muscle permeation study ensures the enhanced delivery of tigecycline to the deeper tissue. The prepared nanoparticles were hemo-compatible and cyto-compatible. Our study suggests that the prepared tCLNPs can be effectively used for the treatment of S. aureus infected wounds. © 2016 Wiley Periodicals, Inc.

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2016 Journal Article P. Rajitha, Gopinath, D., R.a Biswas, Sabitha, M., and Jayakumar, R., “Chitosan nanoparticles in drug therapy of infectious and inflammatory diseases”, Expert Opinion on Drug Delivery, vol. 13, no. 8, pp. 1177-1194, 2016.[Abstract]

Introduction: Chitosan, a polymer from the chitin family has diverse pharmaceutical and bio-medical utility because of its easy widespread availability, non-toxicity, biocompatibility, biodegradability, rich functionalities and high drug-loading capacity. Recent pharmaceutical research has examined the use of chitosan-based systems for drug delivery applications in various diseases. The availability of functional groups permits the conjugation of specific ligands and thus helps to target loaded drugs to the site of infection/inflammation. Slow biodegradation of chitosan permits controlled and sustained release of loaded moieties; reduces the dosing frequency and is useful for improving patient compliance in infectious drug therapy. The muco-adhesion offered by chitosan makes it an attractive candidate for anti-inflammatory drug delivery, where rapid clearance of the active moiety due to the increased tissue permeability is the major problem. The pH-dependent swelling and drug release properties of chitosan present a means of passive targeting of active drug moieties to inflammatory sites. Areas covered: Development of chitosan-based nanoparticulate systems for drug delivery applications is reviewed. The current state of chitosan-based nanosystems; with particular emphasis on drug therapy in inflammatory and infectious diseases is also covered. Expert opinion: The authors believe that chitosan-based nanosystems, due to the special and specific advantages, will have a promising role in the management of infectious and inflammatory diseases. © 2016 Informa UK Limited, trading as Taylor & Francis Group

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2013 Journal Article T. R. Anuraj, N Rejinold, S., Biswas, R., Saroj, S., Shantikumar V Nair, Jayakumar, R., and Sabitha, M., “Curcumin Nanospheres by Surfactant Free Wet Milling Method (In Press)”, Journal of Biomedical Nanotechnology, 2013.
2012 Journal Article S. Saroj, Baby, D. A., and Sabitha, M., “Current trends in lipid based delivery systems and its applications in drug delivery”, Asian Journal of Pharmaceutical and Clinical Research, vol. 5, pp. 4-9, 2012.[Abstract]

Lipid-based delivery systems are an accepted, proven, commercially viable strategy to formulate pharmaceuticals, for topical, oral, pulmonary or parenteral delivery. Lipid based formulations can be tailored to meet a wide range of product requirements dictated by disease indication, route of administration, cost consideration, product stability, toxicity, and efficacy. The proven safety and efficacy of lipid-based carriers make them attractive candidates for the formulation of pharmaceuticals, as well as vaccines, diagnostics and nutraceuticals. These systems allows oral delivery of poorly soluble API when solubilization through modification of molecular scaffold is not an option The efficacy of these biocompatible systems may be improved if their delivery rate, biodegradation, and site-specific targeting can be predicted, monitored, and controlled. However, the number of applications for lipid-based formulations has expanded as the nature & type of active drugs under investigation has become more varied. This article mainly focus on lipid formulations namely microemulsions, self emulsifying delivery systems, nanoemulsions, pickering emulsions, liposomes, phytosomes, transfersomes, ethosomes, archaesomes, vesosomes, lipid microparticles and lipid nanoparticles and their prominent applications in pharmaceutical drug delivery. More »»
2012 Journal Article S. Raj, Jose, S., Sumod, U. S., and Sabitha, M., “Nanotechnology in cosmetics: Opportunities and challenges”, Journal of Pharmacy and Bioallied Sciences, vol. 4, pp. 186-193, 2012.[Abstract]

Nanotechnology is the science of manipulating atoms and molecules in the nanoscale - 80,000 times smaller than the width of a human hair. The world market for products that contain nanomaterials is expected to reach $2.6 trillion by 2015. The use of nanotechnology has stretched across various streams of science, from electronics to medicine and has now found applications in the field of cosmetics by taking the name of nanocosmetics. This widespread influence of nanotechnology in the cosmetic industries is due to the enhanced properties attained by the particles at the nano level including color, transparency, solubility etc. The different types of nanomaterials employed in cosmetics include nanosomes, liposomes, fullerenes, solid lipid nanoparticles etc. Recently, concerns over the safety of such nanocosmetics are raised and have forced the cosmetic industries to limit the use of nanotechnology in cosmetics and for enforcing laws to undergo a full-fledged safety assessment before they enter into the market. In this review, emphasis is made on the types of nanomaterials used in cosmetics by the various cosmetic brands, the potential risks caused by them both to human life and also to the environment and what all regulations have been undertaken or can be taken to overcome them.

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2012 Journal Article D. Aa Baby, Saroj, Sa, and Sabitha, M., “Mechanism of solubility of liquisolid formulation in non volatile solvent: A review”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 4, pp. 710-715, 2012.[Abstract]

Solubility is one of the important parameter to obtain desired concentration of drug in systemic circulation. Liquisolid technique is one of the most promising techniques to achieve enhanced solubility of poorly soluble drugs. This approach is suitable for immediate or sustained release formulations and this depends upon the solubility of the drug in the non volatile solvents. Non volatile solvents enhance the solubility of water insoluble drugs by formation of micelles and act as dispersants. For immediate release liquisolid compacts, the selection of solvent is based on high drug solubility and for sustained release, solvents with least solubilising capacity is selected. The solubility of drug in non volatile solvents can be revealed by differential scanning calorimetry (DSC) and X- ray powder diffraction (XRPD). Since there are no specific non-volatile liquid vehicles used in the preparation of liquisolid compacts, different non aqueous solvents have been used as non-volatile liquid vehicles in the preparation of immediate release and sustained release liquisolid tablets with different drugs. So selection of non volatile solvent in liquisolid technique is important to obtain immediate or sustained release formulation.

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Publication Type: Patent
Year of Publication Publication Type Title
2011 Patent M. Sabitha, Jayakumar, R., Shantikumar V Nair, Amrita, N., N Rejinold, S., and Lakshmanan, V. Kumar, “The art, method, manner, process and system of preparation of curcumin loaded chitin nanogels for skin penetration”, U.S. Patent 2353/CHE/2011 A2011.[Abstract]

A method for the preparation of chitin nanogel loaded with curcumin without using any organic solvents or surfactants which show deep skin penetration and increased bioavailability of curcumin at sites of cancer with low pH.

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