Dr. Gopi Mohan C. is an Associate Professor at Amrita Center for Nanosciences and Molecular Medicine. He had graduated with Ph.D. from Banaras Hindu University, Varanasi, following which, had gained experience as Post-doctoral fellow from the Molecular Biophysics Unit at the Indian Institute of Science, Bangalore, and as Research Officer from the Department of Biology and Biochemistry, University of Bath, United Kingdom. Further, he had worked as an Associate Researcher of CNRS in Laboratoire de Cristallographie, and Modelisation des Materiaux Mineraux et Biologiques, University Henri Poincare, Nancy, France. 

Dr. Gopi Mohan has experience being a faculty at the National Institute of Pharmaceutical Education & Research (NIPER), Mohali, Punjab, from 2005 and serving there for six and half years. During his stay at NIPER, he has been instrumental in setting up different laboratories in the Pharmacoinformatics discipline. He was a recipient of Indo-Finland grant for computational biology, relating to drug development, and had visited University of Helsinki and University of Turku, to complete this collaborative bilateral program, successfully.

Dr. Gopi Mohan has supervised many Ph.D. and postgraduate students, and completed many research and industrial consultancy projects. He has published more than 70 research papers in refereed journals and is also an active reviewer of different international/national research journals, thesis and grants. Research interests of Dr. Gopi Mohan encompass Computational Biology & Structural Bioinformatics, Structure- Based Drug Design, Protein crystallography, and Nanoinformatics. Dr. Gopi Mohan is cited as an internationally recognized expert in the field of Structural Bioinformatics & Chemoinformatics by Synergix Ltd. United Kingdom.


Publication Type: Journal Article
Year of Publication Publication Type Title
2016 Journal Article P. Geetha, Sivaram, A. J., Jayakumar, R., and C. Mohan, G., “Integration of in silico modeling, prediction by binding energy and experimental approach to study the amorphous chitin nanocarriers for cancer drug delivery”, Carbohydrate Polymers, vol. 142, pp. 240-249, 2016.[Abstract]

In silico modeling of the polymer-drug nanocarriers have now days became a powerful virtual screening tool for the optimization of new drug delivery systems. The interactions between amorphous chitin nanoparticles (AC-NPs) with three different types of anti-cancer drugs such as curcumin, docetaxel and 5-flurouracil were studied by integration of computational and experimental techniques. The drug entrapment and drug loading efficiency of these three drugs with AC-NPs were (98 ± 1%), (77 ± 2%), and (47 ± 12%), respectively. Further, cytotoxicity and cellular uptake studies of drug loaded AC-NPs on Gastric adenocarcinoma (AGS) cells showed enhanced drug uptake and cancer cell death. In silico binding energy (BE) between AC-NPs with these anti-cancer drugs were studied by molecular docking technique. Computational drug's BEs are in excellent agreement with experimental AC-NPs drug loading (R2 = 0.9323) and drug entrapment (R2 = 0.9741) efficiencies. Thus, present integrated study revealed significant insight on chemical nature, strength, and putative interacting sites of anti-cancer drugs with AC-NPs. © 2016 Elsevier Ltd. All rights reserved.

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