Qualification: 
M. Pharm., B. Pham.
jhameed@aims.amrita.edu

Jahanara Hameed joined as Lecturer in the department of Pharmacology, Amrita School of Pharmacy in October 2015. She has more than 5 years experience in teaching. She was working as Lecturer in AM College of Pharmacy, Karunagappally and Lisie College of Pharmacy, Kochi. She has completed M. Pharm. & B. Pharm. from University College of Pharmacy, Ettumanur, MG University, Kottayam. Her area of interest is Neurosciences/ Neurodegenerative disorders.

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2017

Journal Article

P. Rutuparna, Merin, D., Abraham, S., Thomas, N. M., and Jahanara Hameed, “Assesment of clinical effectiveness of losartan and amlodipine in hypertensive patients with left ventricular hypertrophy”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 368-371, 2017.[Abstract]


Objective: Hypertension is an important worldwide public health challenge because of its high frequency and concomitant risks of cardiovascular and kidney diseases. Left ventricular hypertrophy (LVH) is defined as an increase in the mass of the LV, which can be secondary to an increase in wall thickness, an increase in cavity size, or both. Relevant study reported that LVH is one of the major and independent risk factors for coronary artery disease, heart failure, serious dysrhythmias, and sudden death. Thus, regression of LVH is a primary pharmacologic objective. The objective of this study is to assess the effectiveness of losartan and amlodipine in regression of LVH and to monitor the adverse effects of these drugs on monotherapy. The study also focused to estimate the clinical effectiveness of specified drugs in lowering hypertension. Methods: The study conducted was retrospective, prospective, comparative study extended over 1 year on 28 patients based on inclusion and exclusion criteria. Results: Both these drugs cause regression of LVH with a decrease in LV mass index value; it is seen that amlodipine is better in controlling elevated blood pressure (BP), especially diastolic BP. In statistical analysis, regression of LVH was found to be correlated with reduction of BP. Conclusion: Incidence of adverse effect was found to be prominent in amlodipine group. Thus, losartan was found to be better in regressing LVH than amlodipine. © 2017 The Authors.

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2017

Journal Article

A. Sree, Shibina, K. A., and Jahanara Hameed, “In vitro anti-arthritic activity of the polyherbal formulation – Balapunarnavadi choornam”, Journal of Pharmaceutical Sciences and Research, vol. 9, pp. 1281-1282, 2017.[Abstract]


Objective: Arthritis have emerged to be a very common disorder affecting statistically one third of the population. The present study aims to investigate the effectiveness of Balapunarnavadi choornam, a polyherbal formulation in treating the disorder arthritis. The formulation is typically used in the treatment of anorexia and for improving digestion. Methodology: The anti-arthritic activity was investigated in-vitro by protein denaturation method. The aqueous extract of the choornam at different concentration was incubated with bovine serum albumin for complete denaturation and the result was assessed spectrophotometrically at 660nm against the standard diclofenac sodium. Result: The result revealed that the formulation possessed significant anti-arthritic activity and protein denaturation was inhibited by the extract at 200µg/ml - 1000µg/ml in comparison with diclofenac sodium, the standard drug used. Conclusion: The study concluded that the formulation is an effective inhibitor of protein denaturation and showed potent anti-arthritic activity. © 2017, Pharmainfo Publications. All rights reserved.

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2017

Journal Article

S. P. Ittiyavirah and Jahanara Hameed, “Biosynthesis, characterization and evaluation of silver nanoparticles of alternanthera sessilis (linn.) and its ethanolic extract in high fat diet induced dementia model”, International Journal of Phamraceutical Sciences Review and Research., vol. 42, no. 2, pp. 160-165, 2017.

2015

Journal Article

S. P. Ittiyavirah and Jahanara Hameed, “Evaluation of anti-sress activity of ethanolic extract of alternanthera sessilis (linn.) and its silver nanoparticles in chronic variable stress model”, World Journal of Pharmacy and Pharmaceutical Sciences, vol. 4, no. 10, pp. 609-622, 2015.[Abstract]


Biosynthesis of nanoparticles incorporating the herbal extracts can potentially eliminate the toxicity problem. These particles can be prepared easily by different chemical, physical, and biological approaches. But the biological approach is the most emerging approach of preparation, because, this method is easier than the other methods, eco-friendly and less time consuming. The Green synthesis of silver nanoparticles was done by using the ethanolic extract of Alternanthera sessilis (Linn.) and Silver nitrate. The anti stress activity of ethanolic extract of Alternanthera sessilis (Linn.) (EEAS) and its silver nanoparticles (ASAgNPs) were evaluated using forced swim (FST) and open field test following chronic variable stress (CVS). The effect of EEAS (200 mg/kg) and ASAgNPs (20mg/kg) were assessed by the ex vivo biochemical assays by measuring the plasma corticosterone and glucose levels. The behavioural parameters such as rearing, selfgrooming, ambulation activity and Immobility were analysed using open field apparatus and Forced swim test respectively. EEAS and ASAgNPs have shown protective effect against stress in chronic variable stress model. Significant neuroprotection was produced in chronic variable stress model by EEAS. It resulted in a significant (p < 0.001) decrease in immobility time along with a significant increase in locomotion as compared to the stress only group. The reduction in the plasma corticosterone level and glucose levels indicate the reduction in stress in the animals. It is concluded that Alternanthera sessilis (Linn.) may be used as a phytomedicine for Anti-stress. The ethanolic extract exhibited better activity compared to its nanoparticles.

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Faculty Research Interest: 
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