Qualification: 
MDS, BDS
jayachandranp@aims.amrita.edu

Dr. Jayachandran heads the Department of Periodontics at Amrita School of Dentistry. He joined Amrita in September 2007.

He obtained B. D. S. and M. D. S. degrees from A. B. Shetty Memorial Institute of Dental Sciences, Mangalore. Prior joining Amrita, he served as Professor in the Department of Periodontics at A. B. Shetty Memorial Institute of Dental Sciences, Mangalore.

He has recevied award for the outstanding postgraduate guide at FASCEP Conference held at Royal Dental College, Palghat during April 2013.

Dr. Jayachandran has over 16 years of undergratuate and postgraduate teaching experience and has published papers in national and international journals. He is also assisting Post Doctoral Students at Amrita Center for Nanosciences. His keen areas of interest include local drug delivery system and occlusion.

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2017

Journal Article

S. Sowmya, Dr. Ullas Mony, P., J., Reshma, S., R Kumar, A., Arzate, H., Shantikumar V Nair, and Jayakumar, R., “Tri-Layered Nanocomposite Hydrogel Scaffold for the Concurrent Regeneration of Cementum, Periodontal Ligament, and Alveolar Bone.”, Adv Healthc Mater, 2017.[Abstract]


A tri-layered scaffolding approach is adopted for the complete and concurrent regeneration of hard tissues-cementum and alveolar bone-and soft tissue-the periodontal ligament (PDL)-at a periodontal defect site. The porous tri-layered nanocomposite hydrogel scaffold is composed of chitin-poly(lactic-co-glycolic acid) (PLGA)/nanobioactive glass ceramic (nBGC)/cementum protein 1 as the cementum layer, chitin-PLGA/fibroblast growth factor 2 as the PDL layer, and chitin-PLGA/nBGC/platelet-rich plasma derived growth factors as the alveolar bone layer. The tri-layered nanocomposite hydrogel scaffold is cytocompatible and favored cementogenic, fibrogenic, and osteogenic differentiation of human dental follicle stem cells. In vivo, tri-layered nanocomposite hydrogel scaffold with/without growth factors is implanted into rabbit maxillary periodontal defects and compared with the controls at 1 and 3 months postoperatively. The tri-layered nanocomposite hydrogel scaffold with growth factors demonstrates complete defect closure and healing with new cancellous-like tissue formation on microcomputed tomography analysis. Histological and immunohistochemical analyses further confirm the formation of new cementum, fibrous PDL, and alveolar bone with well-defined bony trabeculae in comparison to the other three groups. In conclusion, the tri-layered nanocomposite hydrogel scaffold with growth factors can serve as an alternative regenerative approach to achieve simultaneous and complete periodontal regeneration.

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2015

Journal Article

J. P., Menon, K. Sa, Kurup, Sb, Thomas, A. Eb, Angel Fenol, Vyloppillil, R., Bhaskar, A., and Megha, Sa, “Influence of Vitamin D & calcium supplementation in the management of periodontitis”, Journal of Clinical and Diagnostic Research, vol. 9, pp. ZC35-ZC38, 2015.[Abstract]


Introduction: It has long been recognized that vitamin D is a hormone and were many studies reporting that patients in periodontal maintenance programs taking vitamin D and calcium supplementation had a trend for better periodontal health compared to patients not taking supplementation. Aims: To evaluate the effect of vitamin D and calcium supplementation in reducing gingival inflammation, using clinical parameters like gingival index (GI), oral hygiene index-simplified (OHIS), probing pocket depth (PPD), clinical attachment level (CAL) and bone density (BD). Also, to assess whether calcium and vitamin D oral supplementation influences alveolar Bone Density (BD). Design and Settings: A nonrandomised clinical trial done in Amrita School of dentistry, Kochi, India. Materials and Methods: Group A taking vitamin D (250IU/day) and calcium (500 mg/day) supplementation, and Group B were not taking oral supplementation. All subjects had at least one or more teeth with chronic moderate periodontitis. Digital Orthopantomogram images were taken to assess bone density. Data were collected at baseline and three months. Statistical Analysis used: OHI-S, GI, PPD, CAL, and Bone Densities (BD) were calculated per group. Karl Pearson Coefficient of correlation was used to test correlation of bone density with GI and OHI -S. Intergroup comparison of parameters were done using Independent two Sample t-test. Intragroup comparison of parameters at recall interval was done using Paired sample t-test. The results were considered statistically significant when p-value was <0.05. Results: Both Groups showed significant change in the periodontal parameters and bone density after three months and intragroup comparison showed highly significant results for vitamin D group in relation to GI, OHI S and bone density. Conclusions: Calcium and vitamin D supplementation has got a positive effect on periodontal health and it can be used as an adjunct to non surgical periodontal therapy. © 2015, Journal of Clinical and Diagnostic Research. All Rights Reserved.

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2014

Journal Article

J. P., Suresh, N., Angel Fenol, Vyloppillil, R., Bhaskar, A., and Menon, S. Megha, “Comparison of glycated hemoglobin levels in individuals without diabetes and with and without periodontitis before and after non-surgical periodontal therapy”, Journal of Periodontology, vol. 85, pp. 1658-1666, 2014.[Abstract]


Background: Only a few studies have examined the association between periodontitis and glycated hemoglobin (HbA1c) levels in individuals without diabetes. The aim of this study is to compare HbA1c levels in individuals without diabetes and with and without periodontitis before and after non-surgical periodontal therapy. Methods: This comparative study was done on individuals without diabetes who were 35 to 65 years old. Group A consisted of 30 individuals without periodontitis, and group B consisted of 30 individuals with periodontitis. Body mass indices and clinical parameters, including oral hygiene indexsimplified (OHI-S) score, gingival index (GI), probing depth (PD), clinical attachment level (CAL), and HbA1c level, of all participants were recorded. All participants received non-surgical periodontal therapy (scaling and root planing). After 3 months, all participants were reexamined, and clinical parameters and HbA1c levels were evaluated and compared to baseline values. Results: There were significant differences between group A and group B in regard to baseline OHI-S, GI, PD, and HbA1c (P <0.05). There was no clinical attachment loss in group A, either at baseline or after 3 months. At the end of 3 months, group B showed improvement in all clinical parameters (P <0.05) and their HbA1c levels also significantly decreased (P <0.05), although the values never reached those of group A. Conclusion: The HbA1c levels of individuals without diabetes and with periodontitis (group B) were significantly reduced 3 months after non-surgical periodontal therapy, although they never reached the same levels as those of the individuals without diabetes or periodontitis (group A). © 2014 American Academy of Periodontology.

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Faculty Research Interest: 
207
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AMRITA
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