Qualification: 
M. Pharm.
jipnomonjoseph@aims.amrita.edu

Mr. Jipnomon Joseph joined in Amrita, Department of Pharmacology in May 2010. He completed Bachelor’s degree in Pharmacy from Dr. M.G.R. Medical University, Tamil Nadu and Master’s degree in Pharmacology from Annamalai University, Chidambaram. He has more than 12 years experience in teaching and 11 years in research. He is guiding B.Pharm, M.Pharm and Pharm.D. students.

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2016

Journal Article

Dr. Chandrashekar Janakiram, Venkitachalam, R., and Jipnomon Joseph, “Profile of Institutional Ethics Committees in Dental Teaching Institutions in Kerala, India”, Accountability in Research, vol. 23, pp. 219-229, 2016.[Abstract]


<p>Objectives: To assess the existence, structure, and functioning of Institutional Ethics Committees (IECs) in dental teaching institutions in Kerala. Methodology: A cross-sectional questionnaire-based survey was conducted by personally approaching Heads of Institutions/Ethics Committee (EC) in-charge of all dental colleges (23) in Kerala. The validated questionnaire consisted of two parts. The first part pertained to details of institutions, and the second part assessed the structure and functioning of the IEC. The data obtained was tabulated and analyzed using descriptive statistics. Results: Of the participating 17 colleges, 13 colleges had a functioning IEC. Only four of these IECs were accredited to a central agency. Only one among the 12 colleges completely adhered to recommended structure. Regarding the functioning of IECs, 69% of the IECs had neither a separate application form for ethical review of proposals nor a proforma for its evaluation. On average, more than ten proposals were reviewed in a single EC meeting in 54% of the colleges. Nearly 40% of the IECs had no representation of a lay person. Conclusion: The absence of IEC in four colleges and non-accreditation to a central agency was a matter of concern. Enforced accreditation is the need of the hour to ensure ethical protection to human participants. © 2016 Taylor &amp; Francis.</p>

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2016

Journal Article

S. Padmakumar, Jipnomon Joseph, Neppalli, M. H., Mathew, S. E., Shantikumar V Nair, Dr. Sahadev Shankarappa, and Menon, D., “Electrospun Polymeric Core-sheath Yarns as Drug Eluting Surgical Sutures”, ACS Applied Materials and Interfaces, vol. 8, pp. 6925-6934, 2016.[Abstract]


Drug-coated sutures are widely used as delivery depots for antibiotics and anti-inflammatory drugs at surgical wound sites. Although drug-laden coating provides good localized drug concentration, variable loading efficiency and release kinetics limits its use. Alternatively, drug incorporation within suture matrices is hampered by the harsh fabrication conditions required for suture-strength enhancement. To circumvent these limitations, we fabricated mechanically robust electrospun core-sheath yarns as sutures, with a central poly-l-lactic acid core, and a drug-eluting poly-lactic-co-glycolic acid sheath. The electrospun sheath was incorporated with aceclofenac or insulin to demonstrate versatility of the suture in loading both chemical and biological class of drugs. Aceclofenac and insulin incorporated sutures exhibited 15% and 4% loading, and release for 10 and 7 days, respectively. Aceclofenac sutures demonstrated reduced epidermal hyperplasia and cellularity in skin-inflammation animal model, while insulin loaded sutures showed enhanced cellular migration in wound healing assay. In conclusion, we demonstrate an innovative strategy of producing mechanically strong, prolonged drug-release sutures loaded with different classes of drugs. © 2016 American Chemical Society. More »»

2016

Journal Article

S.K. Kanthlal, Jipnomon Joseph, Pillai, A. K. Baskaran, and Dr. Umadevi P., “Neural effects in copper deficient Menkes disease: ATP7A-a distinctive marker”, Asian Pacific Journal of Tropical Disease, vol. 6, pp. 668-672, 2016.[Abstract]


Menkes disease, also termed as “Menkes's syndrome”, is a disastrous infantile neurodegenerative disorder originated by diverse mutations in cupric cation-transport gene called ATP7A. This gene encodes a protein termed as copper transporting P-type ATP ase, essential for copper ion transport from intestine to the other parts of our body along with other transporters like copper transporter receptor 1 and divalent metal transporter 1. The copper transportation is vital in the neuronal development and synthesis of various enzymes. It is found to be an appreciated trace element for normal biological functioning but toxic in excess. It is essential for the metallation of cuproenzymes which is responsible for the biosynthesis of neurotransmitters and other vital physiological mechanisms. Copper is also actively involved in the transmission pathway of N-methyl-D-aspartate receptors and its subsequent molecular changes in neural cells. The expression of ATP7A gene in regions of brain depicts the importance of copper in neural development and stabilization. Studies revealed that the mutation of ATP7A gene leads the pathophysiology of various neurodegenerative disorders. This review focused on the normal physiological function of the gene with respect to their harmful outcome of the mutated gene and its associated deficiency which detriments the neural mechanism in Menkes patients. © 2016 Asian Pacific Tropical Medicine Press

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2015

Journal Article

A. Ajay, Paravannoor, A., Jipnomon Joseph, Amruthalakshmi, V., Anoop, S. S., Nair, S. V., and Balakrishnan, A., “2 D amorphous frameworks of NiMoO4 for supercapacitors: Defining the role of surface and bulk controlled diffusion processes”, Applied Surface Science, vol. 326, pp. 39-47, 2015.[Abstract]


<p>This study demonstrates a novel approach by which amorphous nickel molybdate nanoflakes were processed into high surface area electrodes for supercapacitors. Time dependent studies showed evolution of flake-like morphology from anisotropic nuclei particles exhibiting high redox activity. An intrinsic correlation between the surface area, specific capacitance and the internal resistance has been deduced and explained on the basis of relative contributions from the faradic reactions of NiMoO4. Relative contributions from the bulk and surface processes were mathematically modeled. The electrodes exhibited specific mass capacitance values as high as 1650 F g-1 which is the highest reported value so far. Coin cells employing these rechargeable electrodes were also demonstrated exhibiting an energy and power density of 92 W h kg-1 and 23 kW kg-1, respectively, with excellent cyclic stability. ©2014 Elsevier B.V. All rights reserved.</p>

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2015

Journal Article

Jipnomon Joseph, Paravannoor, A., Shantikumar V Nair, Han, Z. J., Ostrikov, Kb, and Balakrishnan, A., “Supercapacitors based on camphor-derived meso/macroporous carbon sponge electrodes with ultrafast frequency response for ac line-filtering”, Journal of Materials Chemistry A, vol. 3, pp. 14105-14108, 2015.[Abstract]


Supercapacitor electrodes assembled from meso/macroporous camphor-derived carbon sponges show highly promising performance in ac line-filtering. The coin-type supercapacitor exhibits an ultrafast frequency response with a phase angle of -78°and a RC time constant of 319 μs at 120 Hz and may be a viable alternative to the presently dominant aluminium electrolytic capacitors. © The Royal Society of Chemistry 2015.

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2015

Journal Article

A. MN, Jipnomon Joseph, and Nair, S. C., “Solubility and bioavailability enhancement of albendazole by complexing with hydroxy propyl β cyclodextrin”, Journal of Chemical and Pharmaceutical Research , vol. 7, no. 4, pp. 1131-1141 , 2015.[Abstract]


The solubility and dissolution properties of any drug are vital determinants of its oral bioavailability. The effect of hydroxyl propyl beta cyclodextrin, on the dissolution, bioavailability was evaluated using a commercial suspension as reference product. Both formulations were orally administered in mice. Plasma samples were taken at different times, and drug concentration was assayed by HPLC. Due to the rapid matabolization of ABZ its main metabolite albendazole-sulphoxide(ABZSO), which also has anthelmintic acivity, was assayed. The binary system containing Albendazole and hydroxyl propyl beta cyclodextrin is prepared by kneading method and complex formed is characterized using scanning electron microscope (SEM), DTA, FTIR. .And this binary mixture is formulated into suspension form and optimization of was done by selecting different concentration of hydroypropyl beta cyclodextrin and the formulation is evaluated for sedimentation volume, redispersibility, pH measurement, viscosity measurement and drug content estimation at various time intervals for 3months to find out the effect of hydroy propyl beta cyclodextrin on the stability of Albendazole suspension. In vitro dissolution study, ex vivo study, histopathological studies ,in vitro anthelmintic activity, and zeta potential compared with two marketed formulations Zental and noworm and release rate of ABZ:HPβCD suspension were markedly higher compared with marketed formulation due to increase in the wetting properties of the drug. A bioavailability study on Albino wistar rat was done, bioavailability results shows that ABZ:HPβCD complexes had faster absorption than a conventional ABZ formulation.

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2014

Journal Article

G. S. Anjusree, Deepak, T. G., Pai, K. R. N., Jipnomon Joseph, Arun, T. A., Nair, S. V., and Nair, A. S., “TiO2 nanoparticles @ TiO2 nanofibers-an innovative one-dimensional material for dye-sensitized solar cells”, RSC Advances, vol. 4, pp. 22941-22945, 2014.[Abstract]


We report a unique one-dimensional (1-D) morphology of TiO2 having TiO2 nanoparticles decorating the surface of TiO2 nanofibers fabricated by a simultaneous electrospinning and electrospraying technique. The composite made by both nanofibers and nanoparticles is used as a photoanode material for dye-sensitized solar cells (DSCs) which helped in overcoming the limitations associated with nanofibers and nanoparticles when employed separately. The DSC showed an excellent efficiency of 7.89% (for a square-shaped cell of area 0.2 cm2) in comparison to 6.87% for the nanoparticulate DSC and 5.21% for the nanofiber DSC (for cells of the same area and thickness) which is an impressive value when literature on DSC fabrication with 1-D nanostructures for DSCs is concerned. © 2014 the Partner Organisations.

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2014

Journal Article

S.K. Kanthlal, B. Kumar, A., Jipnomon Joseph, Aravind, R., and P. Frank, R., “Amelioration of oxidative stress by Tabernamontana divaricata on alloxan-induced diabetic rats”, Ancient Science of Life. , vol. 33, no. 4, pp. 222-228. , 2014.[Abstract]


Objective:
The purpose of this study was to evaluate the anti-diabetic activity of ethanol extract of Tabernamontana divaricata (L.) and its ameliorative effect on oxidative stress in alloxan-induced diabetic rats.

Materials and Methods:
Diabetes was induced by single intraperitoneal injection of alloxan monohydrate (140 mg/kg body weight). Methanol extract of T. divaricata was administered at the doses of 100 and 200 mg/kg body weight in diabetic induced rats including glibenclamide (3 mg/kg) as a reference drug. In the continuous 21 days treatment, fasting blood glucose level was determined on 0, 7, 14 and 21 days. On day 21, serum lipid profiles and glycosylated hemoglobin, liver antioxidant enzymes levels were estimated.

Results:
Experimental findings showed a significant anti-diabetic potential of the extract in terms of reduction in blood glucose levels and a correct effect on the altered biochemical parameters. Observed data were found statistically significant in correction of antioxidant enzyme level accompanied with diabetes, particularly at the dose of 200 mg/kg body weight.

Conclusion:
Based on the results, it can be concluded that the T. divaricata is found to be effective in type 2 diabetes in rats and to have an ameliorative effect on the associated oxidative stress.

KEY WORDS: Alloxan, anti-diabetic, antioxidant, methanol extract, Tabernamontana divaricata

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2014

Journal Article

M. M. Shabi, Uthirapathy, S., Raj, D., Krishnamoorthy, G., Ravindhran, D., Jipnomon Joseph, and Rajamanickam, G. V., “Analgesic and Anti-Arthritic Effect of Enicostemma littorale Blume”, Advances in Bioscience and Biotechnology, vol. 05, pp. 1018-1024, 2014.[Abstract]


Background and Objectives: Of late people in many parts of the world have started preferably to consume drugs from the traditional system particularly to rheumatoid authorities. Due to change of life style of the people even at the middle age level arthritic problems appear often. But the herbal drugs under the traditional system have not been properly validated scientifically therefore it is proposed to have Enicostemma littorale (Blume) used in the folk medicine for rheumatic pain was selected for scientific validation. Methods: The 85 % methanolic extract obtained from the whole plant of Enicostemma littorale had been assessed for analgesic and anti-inflammatory activity. The analgesic activity by hot plate and tail immersion methods and the anti-inflammatory, and antioxidant activities had been evaluated by Complete Freund's adjuvant induced arthritic model. Results: The results of the evaluation on analgesic activity in hot plate and tail immersion methods revealed the extracts exhibition of a significant activity at 150 mg/kg b.wt. itself and the effect was found to be increased dose dependently. In Freund's adjuvant induced arthritis, Enicostemma littorale was noticed to decrease the paw volume by 15.81 %. Significant protection was also observed by elevating antioxidant enzymes. Conclusion: In conclusion, the 85 % methanolic extract of Enicostemma littorale possesses significant analgesic and anti-inflammatory activities according to Freund's adjuvant induced arthritic model in rats. Based on this study, Enicostemma littorale can be considered to be a potentially useful drug suitable to control the rheumatoid arthritis.

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2013

Journal Article

M. Na Anjana, Nair, S. Ca, and Jipnomon Joseph, “An updated review of cyclodextrins -an enabling technology for challenging pharmaceutical formulations”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 5, pp. 54-58, 2013.[Abstract]


Cyclodextrins (CDS) due to their complexation ability and other versatile characteristics, widely used in the field of pharmaceutical industry and in different areas of drug delivery system. Cyclodextrin molecules are relatively large molecules with number of hydrogen donors and acceptors, thus in general they do not permeate lipophilic membrane. CDS widely used to enhance the solubility, bioavailability, stability and safety of drug molecules. A number of cyclodextrin based product are now available in market, due to their ability to camouflage undesirable physiochemical properties of drugs. The aim of this review is to discuss about types of cyclodextrins, their use in delivery system, complexation techniques, also focus its use in novel drug delivery system and expected to solve many problems associated with the delivery of different novel drugs through different delivery routes. Studies in both human and animals have shown that cyclodextrins can be used to improve drug delivery from almost any type of drug formulations. However addition of cyclodextrin to any existing formulations without further optimisation will seldom result in acceptable outcome. The objective of this review article is to explain the use of natural and derivatized cyclodextrins in the different routes of administration.

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2013

Journal Article

M. N. Anjana, Jipnomon Joseph, and Nair, S. C., “Solubility enhancement methods -a promising technology for poorly water soluble drugs”, International Journal of Pharmaceutical Sciences Review and Research, vol. 20, pp. 127-134, 2013.[Abstract]


The most challenging task in drug development is enhancement of solubility, dissolution rate, and bioavailability of drug. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. Drug to be absorbed should be in solution form at the site of absorption. Absorption of orally administered drugs will take place only when they show fair solubility in gastric medium and such drugs show good bioavailability. Solubility and dissolution properties of drugs play an important role in the process of formulation and development. Major challenge for formulation scientist is the solubility problem which can be solved by different technological approaches during the pharmaceutical product development work. This review gives detailed information about various technologies used for enhancing solubility and dissolution of poorly soluble drugs, including nanotechnology methods for enhancing solubility to reduce the percentage of poorly soluble drug candidates eliminated from the development. Selection of this solubility enhancing method mainly depends on drug property, site of absorption and dosage form characteristics.

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2013

Journal Article

M. J, Joshi, H., M.P, G., PV, D. Swapna, P, L., Jipnomon Joseph, and Shastr, C. S., “Anticancer potential of bambusa bambos leaf extracts”, International Research Journal of Pharmacy (IRJP), vol. 4, no. 4, 2013.[Abstract]


Anti-canceractivities of chloroform and hydro-alcohol leaf extracts of Bambusa bambos was evaluatedin vitro using Dalton’sLymphoma Ascites (DLA)andEhrlich’s Ascites Carcinoma (EAC)cell lines by Trypan blue dye exclusion method. The chloroform extract exhibited betteractivitycompared to hydro-alcoholextract.Further hemolytic activities of both the extracts were carriedout to measure theextent of damageto normal red blood cell membranes. The findingssuggested that both the extracts produced no signs of hemolysis indicatingthat the extracts are not toxic to normal erythrocytes.

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2013

Journal Article

S. V. Thomas, Sooraj, S., Kanthlal, S. K., Umadevi, P., Kumar, A. B., and Jipnomon Joseph, “Beneficial Effects of Tabernaemontana Divaricata on Locomotor Activity and Body Temperature on Obese Rats”, Indian Journal of Pharmacology, vol. 45, 2013.

2012

Journal Article

A. A. Madhavan, Kumar, G. G., Kalluri, S., Jipnomon Joseph, Nagarajan, S., Nair, S., Subramanian, K. R. V., and Balakrishnan, A., “Effect of embedded plasmonic au nanoparticles on photocatalysis of electrospun TiO2 nanofibers”, Journal of Nanoscience and Nanotechnology, vol. 12, pp. 7963-7967, 2012.[Abstract]


The present study demonstrates an original approach by which Au nanoparticles (∼10 nm) are embedded into TiO2 fibers via electrospinning. The photocatalytic performance of the resultant fibrous material was studied and related to the architecture and the nature of the internal interfaces in the composite. It was found that embedment of nano Au particles into the TiO2 fiber significantly improved the photocatalytic performance as compared to non-embedded ones. Electrospun fibers with the Au nanoparticles (∼10 nm) showed an average fiber diameter of ∼380 nm. The photocatalytic studies of Au embedded TiO2 fibers using ultra-violet (UV) visible spectroscopy showed ∼35% increase in photocatalytic activity when compared to the TiO2 fibers without the Au nanoparticles after 7 hrs of UV irradiation. This increase in photocatalysis was attributed to the ability of Au to increase charge separation in TiO 2 and also to the ability of Au to transfer plasmonic energy to the dye. Copyright © 2012 American Scientific Publishers. All rights reserved.

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2012

Journal Article

M. M Shabi, C Raj, D., Sasikala, C., Gayathri, K., and Jipnomon Joseph, “Negative Inotropic and Chronotropic Effects of Phenolic Fraction from Cynodon dactylon (linn) on Isolated Perfused Frog Heart”, Journal of Scientific Research, vol. 4, pp. 657–663, 2012.[Abstract]


Cynodon dactylon (L.) Pers belongs to the family Poaceae is a grass native to North Africa, Asia and Australia and southern Europe. The phenolic fraction of Cynodon dactylon (Linn) (CDP) was evaluated for its cardio-protective activity using isolated frog´s heart perfusion method. The negative inotropic and chronotropic activities were recorded using kymograph. The CDP produced negative inotropic and chronotropic actions on isolated frog heart. The pharmacological effect was selectively inhibited by atropine indicating that these might have been mediated through muscarinic receptor.

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2012

Journal Article

R. CD, MM, S., Jipnomon Joseph, ,, K, G., U, S., and GV, R., “Terminalia arjuna’s antioxidant effect in isolated perfused kidney”, Research in Pharmaceutical Sciences, vol. 7, no. 3, pp. 181–188, 2012.[Abstract]


Standardization of induction of oxidative stress with Fenton mixture (FM) in isolated perfused rat kidney and the antioxidant effect of Terminalia arjuna bark in the isolated oxidatively stressed rat kidney has been evaluated. Six groups each containing eight isolated perfused rat kidneys were used for the present study and the oxidative stress was induced by perfusing the isolated kidneys with FM. The antioxidant effect of Terminalia arjuna at the dose of 250 and 500 mg/kg was evaluated in oxidative stress induced isolated kidneys. A significant (P<0.05) increase in lipid peroxidation, gluatamate pyruvate transaminase, glutamate oxaloacetate transaminase were observed in oxidative stress induced isolated kidney. On perfusion with extract, the oxidative stress was decreased with increasing in antioxidants while the marker enzymes were found to maintain the normal level. It was concluded from the present study that hydroalcholic extract of Terminalia arjuna bark at the dose of 250 and 500 mg/kg showed significant antioxidant potential in isolated perfused rat kidneys.

Keywords: Terminalia arjuna, Fenton mixture, Rat, Antioxidant, Isolated perfused kidney

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