Qualification: 
M. Pharm., B. Pham.
merinb@aims.amrita.edu

Merin Babu, joined in Department of Pharmacology, Amrita School of Pharmacy in June 2017. She has around one year experience in teaching and research. She was working as Lecturer in the Dale View College of Pharmacy and Research Centre, Trivandrum. She completed B.Pharm and M.Pharm from Amrita Vishwa Vidyapeetham in 2010 and 2016 respectively.

Publications

Publication Type: Journal Article

Year of Publication Title

2020

S. Surendran, Merin Babu, Joseph, J., and Dr. Umadevi P., “Facilitatory effect of Piperine on the Anticonvulsant effect of Sodium valproate against Pentylenetetrazole induced Seizures in mice”, Research Journal of Pharmacy and Technology , vol. 13, no. 2, pp. 651-652, 2020.[Abstract]


The present study was designed to find out the effect of piperine as an adjunctive therapy with sodium valproate against seizures induced by pentylenetetrazole (PTZ). Swiss albino mice (25-35g) received either vehicle, sodium valproate (300mg/kg), piperine (10mg/kg) or their combination orally for 8 days prior to PTZ (60mg/kg i.p.) administration. Sodium valproate significantly (P<0.05) increased the latency for clonic generalized seizures. Treatment with sodium valproate and piperine delayed the onset to both jerks (P<0.05) and clonic generalized seizures (P<0.001). All the animals in the combination group were protected from clonic generalized seizures. Our results suggest a favorable interaction of piperine with sodium valproate against PTZ induced seizures.

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2019

Jahanara Hameed, Davis, D., Scariya, S., and Merin Babu, “An In-vitro Evaluation on Anthelmintic Activity of Different Extracts of Hemigraphics Colorata Leaves”, Research Journal of Pharmacy and Technology, vol. 12, no. 9, pp. 4394-4396, 2019.[Abstract]


Objective: Worm infection is a serious problem affecting millions of people all over the world. Traditional
chemical drugs are not fully effective due to the evolving drug resistant worm strains, so exploring new remedies
derived from natural products is a good way to fight these infections. Hence, the present study was undertaken to
determine the anthelmintic activity of leaves of Hemigraphis colorata. Methodology: The study was carried out
on Indian earthworms (Pheretima posthuma). The effects of different concentrations of fresh juice extract,
ethanolic extract and aqueous extract of the leaves were compared with standard drug Albendazole (20 mg/ml).
Distilled water was taken as the control. The time for paralysis (reduction in motion and movement of worm)
and death of the worms (no movement) were noted. Result: All the extracts (fresh juice, ethanolic and aqueous)
of leaves showed anthelmintic property. The fresh juice extract showed the best result compared to the other two
extracts. The fresh juice extract showed the paralysis and death time at 12 min and 21 min. respectively. In case
of Albendazole group, paralysis and death time was at 6 min and 10 min. respectively. Conclusion: The results
obtained confirm the anthelmintic property of the plant. However, further studies are required to elucidate the
mechanism responsible for the beneficial effect.

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2019

Merin Babu, Thomas, S., and Joseph, J., “Evaluation of Cytotoxic Activity of Annona muricata Fruits and Leaves”, Research Journal of Pharmacy and Technology, vol. 12, pp. 3802-3806, 2019.[Abstract]


Introduction: Screening of various medicinal plants for biological active compounds has become a vital source of cancer related drugs. The present study was designed to evaluate and compare the cytotoxicity of Annona muricata fruits and leaves. Method: The leaves and fruits are dried and standardised by performing ash value, extractive value and phytochemical screening, the dried fruits and leaves of Annona muricata were defatted with petroleum ether and extracted using methanol as solvent. The extracts were evaluated for in-vitro cytotoxic study by MTT assay using Hep G2 cell lines and trypan blue dye exclusion method using DLA and EAC cells. Haemolytic activity was performed to determine the toxicity of extracts to normal cells. Results: The qualitative analysis of phytochemical extracts and parts possesses carbohydrates, cardiac glycosides, alkaloids, flavones and tannins. In MTT assay, while comparing the cytotoxic action of methanolic extracts of Annona muricata leaves and fruits of (MEAML and MEAMF) with standard curcumin (18.6µg/ml), MEAMF (IC50=12.4 µg/ml) showed more cytotoxic action to Hep G2 cell lines than MEAML (IC50=82.5µg/ml). In dye exclusion test, MEAML showed an IC50 value of about 140.3µg/ml, 137.2µg/ml for DLA and EAC respectively, whereas 179.4µg/ml, 165.2µg/ml in MEAMF. None of the extract possessed any haemolytic activity revealing their non-toxicity on normal cells. Conclusion: Methanolic extracts of Annona muricata fruits and leaves possess cytotoxic activity with no significant haemolytic activity towards normal erythrocytes.

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2017

S. Stephen, Markkassery, R., Sainudheen, B. Edathuruth, Merin Babu, Dinesh Balakrishnan, Sudhindran, S., and Padma, U. Devi, “A Comparative Study of Once Daily Versus Twice Daily Tacrolimus in Liver Transplantation”, Journal of Young Pharmacists, vol. 9, pp. 605-609, 2017.[Abstract]


Once daily (OD) tacrolimus, recently launched for post liver transplant immunosuppression might offer better compliance and efficacy compared to standard twice daily (BID) tacrolimus. Data from India, however is sparse. Aim: The aim of our study was to compare the efficacy and adverse effects of OD versus BID tacrolimus formulation in liver transplant recipients. Methods: This was a retrospective, observational, comparative study of 115 patients who were on tacrolimus based regimens (tacrolimus BID: 92; M: F-75:17 and tacrolimus OD: 23; M: F-22:1). Total daily dose and trough levels of tacrolimus were recorded at 1, 3, 6, 12 and 24 months after transplantation. Results: Median age in tacrolimus BID and OD groups were 45 years (6-64 years) and 50 years (1-70 years), respectively. The median tacrolimus dose was significantly lower in the tacrolimus OD arm at all the time points studied. Tacrolimus trough levels were significantly lower in the tacrolimus OD group at 3 and 6 months. The biopsy proven rejection rate was 15.2% and 0% in the tacrolimus BID and OD groups, respectively. Two year patient and graft survival rate was 89.4% in the tacrolimus BID and 87.5% in the tacrolimus OD group. The incidence of new onset diabetes, renal dysfunction, dyslipidemia, neurotoxicity, hyperkalemia and weight gain were comparable between the two arms. Conclusion: Tacrolimus OD has a lower rejection rate compared to its BID formulation. However, this does not translate into better patient or graft survival. Both the formulations appear to be comparable with respect to the adverse effect and tolerability profile.

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2017

Merin Babu and J., J. C., “Rucaparib: a PARP inhibitor for the treatment of advanced ovarian cancer”, International Journal of Basic & Clinical Pharmacology, vol. 6, p. 1018, 2017.[Abstract]


Ovarian cancers arise from the uncontrolled growth and replication of epithelial cells of the surface of ovary which constitutes 90% of cases. PARP (poly ADP-ribose polymerase) inhibitors are a novel type of therapy that prevents cancer cells from repairing their DNA which have been damaged by other chemotherapeutic agents. Rucaparib is a novel drug that was approved by the US FDA in 2016 for the treatment of patients with deleterious BRCA mutation associated advanced ovarian cancer. Inhibition of the PARP enzymes leads to the increased formation of PARP-DNA complexes which results in DNA damage, apoptosis and cell death. Nausea, fatigue including asthenia, vomiting, anemia, abdominal pain, constipation, decreased appetite, diarrhea, thrombocytopenia and dyspnea were the common adverse effects seen among rucaparib users. Even though, the drug may cause myleodysplastic syndrome/ acute myeloid leukemia (MDS/AML) it remains as novel therapeutic target for the treatment of advanced ovarian cancer involving BRCA mutation.

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2017

Merin Babu, Menon, V. P., and Dr. Umadevi P., “Epidemiology and outcome among severe sepsis and septic shock patients in a South Indian tertiary care hospital”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 9, p. 256, 2017.[Abstract]


Objective: The objective of this research was to determine the prevalence of severe sepsis and septic shock and evaluate its outcome.Methods: This was a prospective, observational study, in which adult patients with severe sepsis or septic shock were included. Relevant information was collected from medical records and the hospital information system.Results: A total of 250 patients [mean age 57.2 y (range: 18 to 98 y)] was studied. The majority of the patients suffered from severe sepsis (81.2%). Most of the episodes occurred in males (75.2%). Major comorbidities included diabetes mellitus (51.2%), hypertension (44.8%) and chronic liver disease (30.4%). One hundred and seventy-eight patients (147 patients with severe sepsis and 31 patients with septic shock) had a positive culture with urine being the main site of infection. One hundred and two patients (40.8%) had a monomicrobial infection while seventy-six (30.4%) patients had a polymicrobial infection. Within the monomicrobial infections, the gram negative organisms predominated (54%). The mean hospital stay for patients with severe sepsis was 11.5 d. Mortality was noted in 79 patients (40 patients with septic shock and 39 patients with severe sepsis).Conclusion: The main causative pathogens were gram negative bacteria. Admissions meeting septic shock criteria have a high mortality rate. Hence, it is imperative to identify patients who are at high risk and treat them promptly to reduce serious consequences.

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2017

Merin Babu and Jacob, L. M., “A rare case report on pulmonary hamartoma”, Journal of Pharmaceutical Sciences and Research, vol. 9, pp. 1559-1560, 2017.[Abstract]


Hamartomas are non-neoplastic malformations which can be observed in lungs, pancreas, spleen, liver and kidney. Here, we have reported a 43 year old female on treatment for hypothyroidism was presented with complaints of dyspnea. The patient had undergone thyroidectomy 10 years ago. Her chest X-ray showed a solitary pulmonary nodule. The nodule size remained in the size range of 3-4cm. The diagnosis of solitary pulmonary nodule is only to undergo conservative surgery to remove the nodule. © 2017, Pharmainfo Publications. All rights reserved.

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