Dr. Milind Shrinivas currently serves as Assistant Professor at the Department of Chemistry, Amrita School of Arts and Sciences, Amritapuri. He completed Masters in Chemistry from M. J. College, North Maharashtra University. He received his Ph. D. from University of Milan, Italy and Post Doctorals from University of Milano-Bicocca and University of Milan. Prior to joining Amrita, Dr. Milind worked as Senior Post Doc. at the Institute of Molecular Sciences and Technologies of the National Research Council. He got initial training with Insecticides and residue testing wing, Pune, CSIR’s National Chemical Laboratory, Pune and industrial exposure with Hikal and LeedsKem in R&D Division.

He was awarded Bhaskara Advanced Solar Energy (BASE) Fellowship Award 2015 from Indo-US Science and Technology forum and DST Start up research grants scheme for Young Scientists (2015-2018).


  • Organic Synthesis – (Drugs discovery, Heterocyclic, monomers, Polymers, Asymmetric, Catalysis)


  1. DST- Start up research grants scheme for Young Scientists (2015-2018)
  2. Awarded Bhaskara Advanced Solar Energy (BASE) Fellowship Award 2015 (Indo-US Science and Technology forum)



  1. XVII National Congress of Catalysis GIC 2013 and XI National Congress of Zeolites Science and Technology; 15 - 18 September 2013, Riccione, Italy
  2. “EFCATS Summer school 2012 and 1ST Italian-Spanish School on Cataysis”; 11-15 Sept 2012 in Verbania – Pallanza, Italy
  3. The challenges of industrial chemistry for sustainable innovation “XVIII National Congress DCI SCI”; 11-14 June 2012 in Florence, Italy
  4. International ACS-CSIR Joint Conference on Building Bridges, Forging Bondsfor 21st century organic chemistry chemical biology (ACS-CSIR-OCCB-21st Century) at National Chemical  Laboratory, Pune, India; 7-9 January 2006


Publication Type: Journal Article
Year of Conference Publication Type Title
2016 Journal Article B. Costa, Dangate, M., Vetro, M., Donvito, G., Gabrielli, L., Amigoni, L., Cassinelli, G., Lanzi, C., Ceriani, M., De Gioia, L., Filippi, G., Cipolla, L., Zaffaroni, N., Perego, P., and Colombo, D., “Synthetic sulfoglycolipids targeting the serine–threonine protein kinase Akt”, Bioorganic and Medicinal Chemistry, vol. 24, pp. 3396-3405, 2016.[Abstract]

The serine–threonine protein kinase Akt, also known as protein kinase B, is a key component of the phosphoinositide 3-kinase (PI3K)–Akt–mTOR axis. Deregulated activation of this pathway is frequent in human tumors and Akt-dependent signaling appears to be critical in cell survival. PI3K activation generates 3-phosphorylated phosphatidylinositols that bind Akt pleckstrin homology (PH) domain. The blockage of Akt PH domain/phosphoinositides interaction represents a promising approach to interfere with the oncogenic potential of over-activated Akt. In the present study, phosphatidyl inositol mimics based on a β-glucoside scaffold have been synthesized as Akt inhibitors. The compounds possessed one or two lipophilic moieties of different length at the anomeric position of glucose, and an acidic or basic group at C-6. Docking studies, ELISA Akt inhibition assays, and cellular assays on different cell models highlighted 1-O-octadecanoyl-2-O-β-D-sulfoquinovopyranosyl-sn-glycerol as the best Akt inhibitor among the synthesized compounds, which could be considered as a lead for further optimization in the design of Akt inhibitors. © 2016 Elsevier Ltd

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2014 Journal Article N. Scotti, Dangate, M., Gervasini, A., Evangelisti, C., Ravasio, N., and Zaccheria, F., “Unraveling the Role of Low Coordination Sites in a Cu Metal Nanoparticle: A Step toward the Selective Synthesis of Second Generation Biofuels”, ACS Catalysis, vol. 4, pp. 2818–2826, 2014.[Abstract]

The acidity of a prereduced Cu/SiO2 catalyst was extensively investigated by means of FT-IR of adsorbed pyridine and by titration with 2-phenylethylamine in cyclohexane. Comparison with the parent CuO/SiO2 material, which was already shown to exhibit Lewis acid sites due to the high dispersion of the CuO phase, provided evidence that reduction of this phase to the metallic state increases the acidity of the material. This allowed us to set up a bifunctional catalyst showing acidic and hydrogenation activity, both ascribable to the presence of the metal particle, without the need of an acidic support. This catalyst was tested in the one-pot transformation of γ–valerolactone into pentyl valerate and showed comparable activity (91% vs 92% conversion) and improved selectivity (92% vs 72%) with respect to the previously reported copper catalyst supported on acidic material. The role of Cu in activating the substrate was also evidenced through FTIR of adsorbed γ-valerolactone.

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2013 Journal Article N. Shaikh, Colombo, D., Ronchetti, F., and Dangate, M., “SQAGs: A stepping stone in the biotic world”, Comptes rendus. Chimie, vol. 16, pp. 850–862, 2013.[Abstract]

Multi-targeting drug discovery research has been driven, medically, commercially and intellectually; this need has often been equated with the identification and exploitation of novel targets. Glycolipids present both potentials and problems, their biological relevance has been recognized, but problems in procuring lipids rendered them a difficult class of compounds to handle in drug discovery efforts. Sulfoquinovosylacylglycerols (SQAGs), which are one of the abundant sulfur-containing glycerolipids in the biotic world, isolated from different phototrophic organisms, particularly plants and algae, have already been identified as bioactive compounds. In addition to their antiviral activity, their influence on the immune response in mammalian cells is the focus of many studies shown to have an important role in several biological activities. The purpose of this contest is to spotlight the longtime untouched topics of availability, historical background synthesis and recent findings of SQAG's as mammalian DNA polymerase inhibitor, antiangiogenesis, radiosensitizer, immunosuppressive quality, HIV-reverse transcriptase inhibitor, not only for optimizing the treatment of cancer but also for developing the therapeutic approaches for various diseases. This is definitely the beginning of the revolution in the biotic world.

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2013 Journal Article E. Herrera Calderon, Dangate, M., Manfredi, N., Abbotto, A., Salamone, M. M., Ruffo, R., and Mari, C. M., “Electrochemical and Spectroelectrochemical Properties of a New Donor–Acceptor Polymer Containing 3, 4-Dialkoxythiophene and 2, 1, 3-Benzothiadiazole Units”, polymers, vol. 5, pp. 1068–1080, 2013.[Abstract]

A new heteroarylene-vinylene donor-acceptor low bandgap polymer, the
poly(DEHT-V-BTD), containing vinylene-spaced efficient donor (dialkoxythiophene) and
acceptor (benzothiadiazole) moieties, is presented. Electropolymerization has been carried
out by several electrochemical techniques and the results are compared. In particular,
the pulsed potentiostatic method was able to provide layers with sufficient amounts of
material. Cyclic voltammetries showed reversible behavior towards both p- and n-doping.
The HOMO, LUMO, and bandgap energies were estimated to be −5.3, −3.6 and 1.8 eV,
respectively. In situ UV-Vis measurements have established that the presence of the
vinylene group stabilizes the formation of polaronic charge carriers even at high doping levels.

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2012 Journal Article A. Abbotto, Seri, M., Dangate, M., De Angelis, F., Manfredi, N., Mosconi, E., Bolognesi, M., Ruffo, R., Salamone, M. M., and Muccini, M., “A vinylene-linked benzo [1, 2-b: 4, 5-b'] dithiophene-2, 1, 3-benzothiadiazole low-bandgap polymer”, Journal of Polymer Science Part A: Polymer Chemistry, vol. 50, pp. 2829–2840, 2012.[Abstract]

A new heteroarylene-vinylene donor–acceptor polymer P(BDT-V-BTD) with reduced bandgap has been synthesized and its photophysical, electronic and photovoltaic properties investigated both experimentally and theoretically. The structure of the polymer comprises an unprecedented combination of a strong donor (4,8-dialkoxy-benzo[1,2-b:4,5-b']dithiophene, BDT), a strong acceptor (2,1,3-benzothiadiazole, BTD) and a vinylene spacer. The new polymer was obtained by a metal-catalyzed cross-coupling Stille reaction and fully characterized by NMR, UV–vis absorption, GPC, TGA, DSC and electrochemistry. Detailed ab initio computations with solvation effects have been performed for the monomer and model oligomers. The electrochemical investigation has ascertained the ambipolar character of the polymer and energetic values of HOMO, LUMO and bandgap matching materials-design rules for optimized organic photovoltaic devices. The HOMO and LUMO energies are consistently lower than those of previous heteroarylene-vinylene polymer while the introduction of the vinylene spacer afforded lower bandgaps compared to the analogous system P(BDT-BTD) with no spacer between the aromatic rings. These superior properties should allow for enhanced photovoltages and photocurrents in photovoltaic devices in combination with PCBM. Preliminary photovoltaic investigation afforded relatively modest power conversion efficiencies of 0.74% (AM 1.5G, 100 mW/cm2), albeit higher than that of previous heteroarylene-vinylene polymers and comparable to that of P(BDT-BTD). More »»
2010 Journal Article A. Abbotto, Calderon, E. Herrera, Dangate, M., De Angelis, F., Manfredi, N., Mari, C. Maria, Marinzi, C., Mosconi, E., Muccini, M., Ruffo, R., and , “Pyridine- EDOT Heteroarylene- Vinylene Donor- Acceptor Polymers”, Macromolecules, vol. 43, pp. 9698–9713, 2010.[Abstract]

Two heteroarylene-vinylene donor−acceptor polymers, P(2,6-Py-V-EDOT) and P(2,5-Py-V-EDOT), containing vinylene-spaced simple donor (EDOT) and acceptor (pyridine) moieties, are presented. The central pyridine ring of the repeating unit is either 2,6- or 2,5-substituted, leading to different structural and electronic properties of the monomers. Polymers were obtained by either oxidative electropolymerization or Yamamoto coupling and fully characterized by NMR, UV−vis absorption, GPC, TGA, DSC, electrochemistry, and spectroelectrochemistry. Detailed ab initio computations have been performed for the monomers and model oligomers for analyzing their optical and electronic properties. GPC showed that isolated polymers obtained via Yamamoto poly coupling have low molecular weights, likely due to solubility issues. The electrochemical polymerizations led to p- and n-dopable polymers, with 2,5-Py-V-EDOT yielding more reversible n-doped process. The energetic positions revealed HOMO (−5.1 and −5.0 eV), LUMO (−3.4 eV), and narrow bandgap (1.6 and 1.7 eV) energies closely matching materials-design rules for optimized organic photovoltaic devices. Preliminary investigation in photovoltaic devices in combination with C71−PCBM afforded relatively modest power conversion efficiencies of ∼0.5% (AM 1.5G, 100 mW/cm2), which were attributed to the low molecular-weight of the polymers accessible via the chemical route.

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2009 Journal Article M. Dangate, Franchini, L., Ronchetti, F., Arai, T., Iida, A., Tokuda, H., and Colombo, D., “2-O-β-D-Glucopyranosyl-sn-glycerol based analogues of sulfoquinovosyldiacylglycerols (SQDG) and their role in inhibiting Epstein-Barr virus early antigen activation”, Bioorganic & medicinal chemistry, vol. 17, pp. 5968–5973, 2009.[Abstract]

New sulfoquinovosyldiacylglycerols derived from 2-O-β-d-glucopyranosyl-sn-glycerol, carrying acyl chains of various length on the glycerol moiety, were prepared through a convenient synthetic procedure in which a sulfonate is introduced at the C-6 position of glucose by oxidation of a thioacetate in the presence of the unprotected secondary hydroxyl groups, and tested for their anti-tumor-promoting activity using a short-term in vitro assay for Epstein-Barr virus early antigen (EBV-EA) activation. Our study has allowed to ascertain the role of the 6′-sulfonate group and the need of a free hydroxyl group on the glycerol moiety in inhibiting the EBV activation promoted by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).

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2009 Journal Article M. Dangate, Franchini, L., Ronchetti, F., Arai, T., Iida, A., Tokuda, H., and Colombo, D., “Short Regioselective Chemoenzymatic Synthesis and Biological Evaluation of 2-O-β-D-Sulfoquinovosylmonoacylglycerols”, European journal of organic chemistry, vol. 2009, pp. 6019–6026, 2009.[Abstract]

A convenient chemoenzymatic synthesis of a new class of non-natural sulfo-glycolipids – 2-O-(β-d-sulfoquinovosyl)-monoacylglycerols (2-O-β-d-SQMG) – derived from 2-O-(β-d-glucopyranosyl)glycerol and carrying acyl chains ofvarious lengths at the 1-position of the sn-glycerol moiety, was performed with the aid of a key step involving regioselective lipase-catalyzed acylation of 2-O-(6-deoxy-6-tosyl-β-d-glucopyranosyl)-sn-glycerol (4) at its 1-position, reported here for the first time. Elaboration of the sugar moiety through thioacetate substitution of the selectively inserted tosyl group with subsequent Oxone® oxidation in the presence of unprotected primary and secondary hydroxy groups efficiently afforded the target compounds, the hexanoyl, dodecanoyl, and octadecanoyl derivatives 1a–c, which were active when tested in the EBV-EA in vitro assay for antitumor promoters.

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Publication Type: Conference Proceedings
Year of Conference Publication Type Title
2016 Conference Proceedings M. Dangate, “DFT-TDDFT Study of optoelectronic properties of impact of position on the vinyl based systems”, National Conference on Materials Science and Technology. Thiruvananthapuram, Kerala, India, 2016.
2016 Conference Proceedings S. Chinnusamy, K, A. T., B, A. K., J, B., P, A., Lal, A., and Dangate, M., “Density Functional Theory Investigations on the Electronic and optical Properties of Vinyl Based Systems ”, National Conference on Recent Innovations in Science, Engineering and Technology NCRISET. Maharashtra, India, 2016.
2016 Conference Proceedings M. Dangate, Munshi, A., Sampath, W. S., Boltalina, O., Strauss, S., C, S., and Shantikumar V Nair, “Investigation of Organic Small Molecules and Polymer Compounds for CdTe Back Contact”, 43rd IEEE Photovoltaic Specialists Conference. Portland, Oregon, USA, 2016.
2011 Conference Proceedings A. Abbotto, Calderon, E. Herrera, Dangate, M., Manfredi, N., Mari, C. Maria, Marinzi, C., Ruffo, R., De Angelis, F., Mosconi, E., Ndobe, A., and Muccini, M., “Hybrid Low Bandgap Pyridine Based Vinylene Donor-Acceptor Conjugated Polymers for Bulk Heterojunction Solar Cells”, Organic photovoltaics conference HOPV 2010. Assisi, Italy , 2011.
2010 Conference Proceedings M. Seri, Manfredi, N., Dangate, M., Maggini, M., Abbotto, A., and Muccini, M., “A new series of donors and acceptor materials for OPV BHJ solar cells”, 3rd Hybrid and organic photovoltaics conference 2011. Valencia, Spain, 2010.
2009 Conference Proceedings M. Dangate, Colombo, D., Franchini, L., Ronchetti, F., and Tokuda, H., “Chemoenzymatic synthesis of sulfoquinovosylmonoacylglycerol (SQMG) as anti tumor promoters”, 15th European Carbohydrate Symposium. University of Vienna, Vienna, Austria , 2009.
2009 Conference Proceedings M. Dangate, Colombo, D., Franchini, L., Ronchetti, F., and Grazia, M., “Sulfoglycolipids as New Molecules for Tumor Treatment”, A. Castellani’’ Dei Dottorandi Di Ricerca in Discipline Biochimiche. Brallo di Pregola (PV), Italy, 2009.
2009 Conference Proceedings M. Dangate, Colombo, D., Franchini, L., Ronchetti, F., and Cattaneo, M., “2-O-β-D-Glucosylglycerol Based Analogues of Sulfoquinovosylacylglycerols”, 8th Carbohydrate Bioengineering International Meeting. Ischia, Italy , 2009.
2008 Conference Proceedings M. Dangate, Colombo, D., Franchini, L., and Ronchetti, F., “Sulfoglycolipids: New Molecule For Tumor Treatment”, X Congress School on Carbohydrate Chemistry. Pontignano (SI), Italy , 2008.
2008 Conference Proceedings M. Dangate, Colombo, D., Franchini, L., and Ronchetti, F., “Sulfoglycolipids as New Molecules for Tumor Treatment”, 21a Riunione Nazionale ‘‘A. Castellani’’ Dei Dottorandi Di Ricerca in Discipline Biochimiche. Brallo di Pregola (PV), Italy, 2008.
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