Jayalekshmi H. currently serves as Assistant Professor at the School of Biotechnology. She received her M. Phil. in Microbiology, Bharathidasan University, Tamil Nadu, 2007. She was also conferred M. Sc. Microbiology, Kasturba Medical College, Manipal University, Manipal in 1999.


  • M.Phil(Microbiology)-Bharathidasan University, Tamil Nadu.
  • M Sc (Medical Microbiology), Kasturba Medical College, Manipal University, Karnataka B.Sc (Zoology), Kerala University, Kerala
  • B.Sc (Zoology), Kerala University, Kerala


Previous affiliations

  • Senior Lecturer (January 2014 - till date), Amrita School of Biotechnology, Amritapuri, Kerala.
  • Lecturer (October 2007- December 2014), Amrita School of Biotechnology, Amritapuri, Kerala
  • Senior Research fellow (2003- 2004) in CSIR funded project “Biochemical markers of alchoholic diseases”, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Gangtok, Sikkim.
  • 4. Senior Research Fellow (2002 – 2003) in ICAR funded project ‘All India Net work Programme on Hemorrhagic Septicemia’ College of Veterinary and Animal Science, Kerala Agriculture University, Thrissur, Kerala.
  • 5. Microbiologist (2000 – 2002), Amrita Institute of Medical Sciences, Kochi,Kerala.





Publication Type: Conference Proceedings
Year of Publication Publication Type Title
2013 Conference Proceedings H. .Jayalekshmi, “Effect of Mangroves Extracts on Quorum Sensing and Biofilm Formation in S.aureus and P.aeruginosa.”, Amrita Bioquest. Kollam,Kerala, 2013.
2011 Conference Proceedings H. .Jayalekshmi, “Effect of Clove Bud Essential Oil on Quorum Sensing Virulence Factors of P.aeruginosa. ”, BG.International Conference on New Horizons in Biotechnology, . Thiruvananthapuram,Kerala, 2011.
2011 Conference Proceedings H. .Jayalekshmi, Sree, P. D., and Nair, B. G., “Effect of Plant Essential Oils on Biofilm Formation and Adherence of Multidrug Resistant Staphylococcus aureus.”, 98th Indian Science Congress . SRM University, Chennai , 2011.
2011 Conference Proceedings M. Dhaneesha, D. Pai, A., and .Jayalekshmi, H., “Screening of Dietary Substances: New Blockade Strategy on Quorum Sensing. ”, 98th Indian Science Congress . SRM University, Chennai, 2011.
2008 Conference Proceedings H. .Jayalekshmi, S, D., A, C., M, M., and DM, V., “Effect of Chronic Ethanol Administration on Testicular Antioxidant System and Steriodegic Enzyme Activity in Rats and its Reversal with Ascorbic Acid”, National conference of the Association of Physiologists & Pharmacologists of India. Kasturba Medical College, Mangalore, 2008.
Publication Type: Journal Article
Year of Publication Publication Type Title
2009 Journal Article M. Mailankot, .Jayalekshmi, H., Chakrabarti, A., Alang, N., and Vasudevan, D. M., “Effect of Alpha-Tocopherol Supplementation on Renal Oxidative Stress and Na+/K+-Adenosine Triphosphatase in Ethanol Treated Wistar Rats.”, Indian journal of experimental biology, vol. 47, pp. 608–610, 2009.[Abstract]

Ethanol intoxication resulted in high extent of lipid peroxidation, and reduction in antioxidant defenses (decreased GSH, GSH/GSSG ratio, and catalase, SOD and GPx activities) and (Na+/K+)-ATPase activity in kidney. Alpha-tocopherol treatment effectively protected kidney from ethanol induced oxidative challenge and improved renal (Na+/K+)-ATPase activity. Ethanol induced oxidative stress in the kidney and decreased (Na+/K+)-ATPase activity could be reversed by treatment with ascorbic acid. More »»
2009 Journal Article M. Mailankot, Kunnath, A. P., .Jayalekshmi, H., Koduru, B., and Valsalan, R., “Radio Frequency Electromagnetic Radiation (RF-EMR) from GSM (0.9/1.8 GHz) Mobile Phones Induces Oxidative Stress and Reduces Sperm Motility in Rats”, Clinics, vol. 64, pp. 561–565, 2009.[Abstract]

Mobile phones have become indispensable in the daily lives of men and women around the globe. As cell phone use has become more widespread, concerns have mounted regarding the potentially harmful effects of RF-EMR from these devices. 
OBJECTIVE: The present study was designed to evaluate the effects of RF-EMR from mobile phones on free radical metabolism and sperm quality More »»
2006 Journal Article M. Maneesh, .Jayalekshmi, H., Singh, T. A., and Chakrabarti, A., “Impaired Hypothalamic-Pituitary-Gonadal Axis Function In Men With Diabetes Mellitus”, Indian journal of clinical biochemistry, vol. 21, pp. 165–168, 2006.[Abstract]

In view of association of diabetes mellitus and male infertility, present study was designed to investigate the functional status of hypothalamic pituitary gonadal (HPG) axis in diabetic men. Thirty-five diabetic men (BMI 22.24±0.21) in the age group 20–40 (30.6±4.7) years were selected. Twenty-five healthy men (BMI 23.85±0.25), in the same age group (29.5±4.8) served as control. Blood samples were collected for hormonal and biochemical estimations. Diabetic men had significantly low serum testosterone with low LH and FSH, hypercholesterolemia, hypertriglyceridemia, hypoalbuminemia and increased oxidative stress. Low serum testosterone in diabetic men was accompanied by low LH and FSH; the inability of the pituitary gland to respond appropriately to a decline in testosterone implying central effect of high serum glucose on the interaction between the nervous and endocrine system. Nutritional deficiency, increased oxidative stress and increased aromatase activity due to excessive body fat might have also contributed to low serum testosterone. More »»
2006 Journal Article M. Maneesh and .Jayalekshmi, H., “Antioxidants as Therapeutical Agents for Male Infertility. ”, Journal International Medical Sciences Academy , 2006.
2006 Journal Article M. Maneesh and .Jayalekshmi, H., “Role of Reactive Oxygen Species and Antioxidants on Pathophysiology of Male Reproduction”, Indian Journal of Clinical Biochemistry, vol. 21, pp. 80–89, 2006.[Abstract]

The excessive generation of reactive oxygen species (ROS) by abnormal spermatozoa and contaminating leukocytes has been defined as one of the few etiologies for male infertility. Administration of antioxidants in patients with ‘male factor’ infertility has begun to attract considerable interest. The main difficulty of such an approach is our incomplete understanding of the role of free radicals in normal and abnormal sperm function leading to male infertility. Mammalian spermatozoa membranes are very sensitive to free radical induced damage mediated by lipid peroxidation, as they are rich in polyunsaturated fatty acids. Limited endogenous mechanisms exist to reverse these damages. ROS attacks the fluidity of the sperm plasma membrane and the integrity of DNA in the sperm nucleus. ROS induced DNA damage accelerate the germ cell apoptosis. Unfortunately spermatozoa are unable to repair the damage induced by excessive ROS as they lack the cytoplasmic enzymes required to accomplish the repair. Assessment of such oxidative stress status (OSS) may help in the medical treatment. Treatment strategies must be directed toward lowering of ROS levels to keep only a small amount necessary to maintain normal cell function. More »»
2005 Journal Article M. Maneesh and .Jayalekshmi, H., “Effect of Ascorbic Acid, Alpha-Tocopherol, Lecithin and L-ornithine-L-aspartate on Ethanol Induced Hypoproteinemia and Hyperlipidemia in Rats”, Indian journal of physiology and pharmacology, vol. 49, p. 422, 2005.[Abstract]

We studied effect of exogenous ascorbic acid, α-tocopherol,lecithin and L-ornithine-L-aspartate on serum lipids and proteins inexperimental hepatotoxic Wistar rats. Eleven groups (n = 6) of animals were used. Hepatotoxicity was induced by administering ethanol (1.6g/kg/day) for 28 days. Both preventive and curative options were studied.Percentage increase in body weight was significantly lower in ethanol treated rats Ethanol significantly (P<0.05) increased cholesterol, triglycerides and LDL, and decreased protein, albumin and A: G ratio in serum. Ascorbic acid, α-tocopherol, lecithin and L-ornithine-L-aspartate exhibited an ability to counteract the alcohol-induced changes in the body weight and biochemical parameters in preventive and therapeutic models in varying degree. Antioxidants showed better effect. More »»
2005 Journal Article M. Maneesh, .Jayalekshmi, H., Suma, T., Chatterjee, S., Chakrabarti, A., and Singh, T. A., “Evidence for Oxidative Stress in Osteoarthritis”, Indian journal of clinical Biochemistry, vol. 20, pp. 129–130, 2005.[Abstract]

Evidence of increased oxidative stress in patients of osteoarthritis in comparison with healthy control subjects was investigated by measuring the thiobarbituric acid reactive substances (TBARS), vitamin C, reduced glutathione (GSH) and the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in erythrocytes. It was observed that osteoarthritis patients were more susceptible to oxidative damage than controls as evident from increased TBARS and decreased ascorbic acid, GSH, catalase and GPx in erythrocytes. Significant increase in SOD activity found in patients might be an adaptive response. With the understanding of the role of antioxidants in arthritis, it is becoming increasingly clear that these agents seem to be beneficial in osteoarthritis. More »»
2005 Journal Article M. Maneesh, .Jayalekshmi, H., Dutta, S., Chakrabarti, A., and Vasudevan, D. M., “Role of Oxidative Stress in Ethanol Induced Germ Cell Apoptosis—an Experimental Study in Rats”, Indian Journal of Clinical Biochemistry, vol. 20, pp. 62–67, 2005.[Abstract]

The study was undertaken to evaluate the possible involvement of oxidative stress in the pathogenesis of ethanol induced testicular atrophy in rats. Adult male rats were orally administered ethanol at a dose of 1.6 g/kg body weight/day for four weeks. Twenty-four hours after the last treatment the rats were sacrificed using anesthetic ether. Testes were removed and weighed. Apoptosis was studied by using the Feulgen reaction on 5 μ thin paraffin sections of testis. Testicular homogenate was prepared and centrifuged. The supernatant was used for the estimation of extent of lipid peroxidation and antioxidant defense status. There was significant reduction in body weight: and in testicular weight and diameter in ethanol treated rats. Extent of germ cell apoptosis was significantly high in ethanol treated rats. Ethanol treated rats showed significantly high tissue TBARS level and glutathione S-transferase activity; and low tissue ascorbic acid, reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities. Chronic ethanol administration resulted in high oxidative stress in the testes either due to increased extent of lipid peroxidation or due to decreased antioxidant defenses, and thereby induces germ cell apoptosis leading to testicular atrophy.

More »»
2005 Journal Article M. Maneesh, .Jayalekshmi, H., Dutta, S., Chakrabarti, A., and Vasudevan, D. M., “Effect of Chronic Ethanol Administration on Testicular Antioxidant System and Steroidogenic Enzyme Activity in Ratsc”, Indian J Exp Biol, vol. 43, pp. 445–449, 2005.[Abstract]

In order to find out the effect of chronic ethanol administration on testicular antioxidant system and steroidogenic enzyme activity, male rats fed with ethanol 1.6g/kg body weight per day for four weeks were studied. Besides a drastic reduction in body and testis weight, there was decrease in ascorbic acid, reduced glutathione and activities of superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase in the testicular tissue of the treated animals. Simultaneously, there was increase in lipid peroxidation and glutathione S-transferase activity. Activities of 3β-hydroxy steroid dehydrogenase and 17β-hydroxy steroid dehydrogenase were also found decreased in the treated animals. The results indicate that chronic ethanol administration resulted in increase in oxidative stress and decrease in the activities of steroidogenic enzymes in the rat testes.

More »»

Participation In Conference And Workshop

i plant workshop,Amrita School of Biotechnology,Amritapuri,Kollam,Kerala. August 2014
Workshop on Introduction to research methodology-conducted by IIT Bombay -Amrita School of Engineering,Amritapuri,Kerala June 2012
Workshop on Basic Concepts in Modern Biology ,Amrita School of Biotechnology,Amritapuri,Kerala December 2006
Training workshop on AIDS,Kasturba Medical College,Manipal,Manipal University,Karnataka December 1998
XXII National congress of Indian association of Medical Microbiologists.Kasturba Medical College,Manipal,Manipal University,Karnataka. November 1998
Workshop on Rapid diagnostic techniques in Clinical microbiology with special emphasis to HIV and Tuberculosis,Kasturba Medical College,Manipal,Manipal University,Karnataka. November 1998
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