Qualification: 
Ph.D
nasrinis@am.amrita.edu

Dr. Nasrin Shaikh currently serves as Assistant Professor (Sr.Gr) at the Department of Chemistry, Amrita School of Arts and Sciences, Amritapuri.

Dr. Nasrin research efforts focus on organic, bioorganic and material chemistry. Biomaterials (metals, ceramics, polymers, glasses, carbon or composite materials) that can be solid or liquid which is used in medical devices or in biological system has many advantageous applications on human health. Different methodology for designing inert material for various use in human body and for synthesizing biomolecules for tissue regeneration. Currently, her recent interesting investigations focus on prohibiting melanin hypepigmentation by using natural products. Everybody face no doubt the Melanin hyperpigmentation in skin. Which cause skin darkening, dark spots, colour change, premature ageing. The aim is to produce low cost treatment of above problems.

Awards and Achievments

  1. VeLica Fellowship: Awarded VeLica CNR Fellowship by the Department of Science and Technology, Govt. of Italia for the year 2011-14
  2. CIMNPIS Scholarship selected by the Director of institute at Unimib from Ministry of Italy in 2010. Consorzio Interuniversitario Nazionale" Metodologe ie Processi Innovativi di Sintesi"(Method and Process for Innovative Synthesis).
  3. Indo Italian (MIUR) Fellowship: Awarded by Italy - India Institute (National chemical laboratory, Pune-India) at the University of Milano-Bicocca, Italy in 2009-2010 (Borse per giovani ricercatori indiano).
  4. Young Researcher fellowship: Awarded by the Institution of Milano-Bicocca (Italy) in May 2008-April 2009.
  5. Graduate Record Exam (GRE): Awarded by ETS in 2005 with score record of 1010/1500.
  6. Test of English As a Foreign Language (TOFEL): Awarded by ETS in 2005 223/250.
  7. State Level Topper in Organic chemistry and cash prize of INR 1000 : Received from University of Pune, Organic chemistry topper award in 2002.
  8. Topper in Inorganic chemistry: Awarded by AKI’S Poona College-Pune in 2001 and 2002.
  9. University Representative of college: Awarded by the Student council at AKI’S Poona College in for the year 2002.
  10. College scholar Award and fellowship: Awarded by Poona College through the program called ‘fellowship for scholars’ under memorandum of understanding for higher education in May 2000-April 2002.
  11. Best NSS girl Award: Awarded by AKI’S Poona College in 2001 for the performance in National Social Services.
  12. Science Exhibition 2000: Awarded first prize in Soap Formation Project at AKI’S Poona College from University of Pune.
     

Seminars

  1. Delivered a lecture on ‘Biomolecules Synthesis And Functionalisation For Tissue Engineering Applications’ (2014) at Centro Congressi ‘‘PalaRiviera’’ Sanbenedetto del Trento- Italy
  2. Delivered a presentation on ‘Carbohydrate Chemistry and Biomaterials’ (2013) at University of Milano-Bicocca, Milan-Italy
  3. Delivered a lecture on ‘Smart Biomaterials for tissue engineering’ at Italo (2013) – Spanish workshop, University of Milano-Bicocca, Milan-Italy
  4. Delivered a presentation on ‘Fridel craft acylation by using solid acid catalyst’ at National Research Council, Milan-Italy

Publications

Publication Type: Journal Article

Year of Conference Publication Type Title

2014

Journal Article

F. Zaccheria, Dr. Nasrin Shaikh, Scotti, N., Psaro, R., and Ravasio, N., “New Concepts in Solid Acid Catalysis: Some Opportunities Offered by Dispersed Copper Oxide”, Topics in Catalysis, vol. 57, pp. 1085–1093, 2014.[Abstract]


Copper oxide supported on silica by the Chemisorption–Hydrolysis technique shows a moderate Lewis acidic character due to coordinative unsaturation of the finely dispersed supported metallic phase. Comparison of this material with a conventional acidic catalyst, namely SiO2–Al2O3, puts in light the advantages of this kind of acidic material in three different reactions. Thus, the use of CuO/SiO2 boosts selectivity toward glucose formation in cellulose deconstruction reactions while $\beta$-alkoxyalcohol are formed with 100 {%} regioselectivity in epoxide ring opening ones. Moreover, preliminary tests on Friedel Crafts acylation of anisole with acetic anhydride show that only the catalyst containing finely dispersed CuO is able to promote this reaction due to both Lewis acidic properties and easy desorption of the acylating agent from the surface.

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2013

Journal Article

Dr. Nasrin Shaikh, Colombo, D., Ronchetti, F., and Dr. Milind Shrinivas, “SQAGs: A Stepping Stone in the Biotic World”, Comptes Rendus Chimie, vol. 16, no. 9, pp. 850 -862, 2013.

2012

Journal Article

F. Santoro, Zaccheria, F., Dr. Nasrin Shaikh, and Ravasio, N., “Aminolysis of Styrene Oxide Over Heterogeneous Acidic Catalysts”, Topics in Catalysis, vol. 55, pp. 606–611, 2012.[Abstract]


Silica alumina and silica zirconia mixed oxides are shown to be effective and regioselective catalysts for the aminolysis of styrene oxide under very mild experimental conditions, giving the corresponding primary $\beta$-amino-alcohol in good to excellent yield.

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2011

Journal Article

Dr. Nasrin Shaikh, Russo, L., Cipolla, L., and Nicotra, F., “Ultrasonic assisted Fischer Glycosylation: Generating Diversity for Glycochemistry”, Molecular Diversity, vol. 15, pp. 341–345, 2011.[Abstract]


In this study ultrasound has been utilised for the Fischer glycosylation using free sugars and sulphuric acid immobilized on silica as catalyst. N-acetyl-d-glucosamine, N-acetyl-d-galactosamine, d-glucose, d-galactose, d-mannose, l-fucose, and lactose were glycosylated with propargyl alcohol or 2-azidoethanol affording the corresponding glycosides, with the production of the $\alpha$-glycopyranoside as the dominant product. Remarkable acceleration of the glycosylation reactions (15 min–2 h compared to several hours) over reported procedures together with good yields were always observed

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2010

Journal Article

Dr. Nasrin Shaikh, Russo, L., Papaleo, E., Giannoni, P., De Gioia, L., Nicotra, F., Quarto, R., and Cipolla, L., “C-type natriuretic peptide: Structural studies, Fragment Synthesis, and Preliminary Biological Evaluation in Human Osteosarcoma cell Lines”, Peptide Science, vol. 94, pp. 213–219, 2010.[Abstract]


Natriuretic peptides (NP) are a family of structurally related but genetically distinct hormones/paracrine factors that regulate blood volume, blood pressure, ventricular hypertrophy, pulmonary hypertension, fat metabolism, and long bone growth. In this work we present computational structural analysis of the three human NP in solution, the synthesis and preliminary biological assays of a short fragment of CNP, I14GSM17, together with one small mimetic, GGSM. Synthetic peptides IGSM, GGSM, and full length CNP were preliminary tested for their ability to influence cell growth of three human osteosarcoma cell lines. Synthetic peptides were shown to successfully mimic the biological activity of the full length natural peptide: their effects, although different upon the cell types used, are in accordance with the current literature, designating a possible role for CNP, and its derivatives, in skeletogenesis. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 213–219, 2010.

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2010

Journal Article

E. Papaleo, Russo, L., Dr. Nasrin Shaikh, Cipolla, L., Fantucci, P., and De Gioia, L., “Molecular Dynamics Investigation of Cyclic Natriuretic Peptides: Dynamic Properties Reflect Peptide Activity”, Journal of Molecular Graphics and Modelling, vol. 28, pp. 834 - 841, 2010.[Abstract]


Natriuretic peptides (NPs) are a family of structurally related hormone/paracrine factors (ANP, BNP and CNP), which mediate a broad array of physiological effects by interacting with specific guanylyl cyclase receptors (NPR) and have promising therapeutic and clinical applications. NPs are specific for different NPRs and share a common ring structure in which a disulfide bond between two conserved cysteine residues is formed. Residues within the cyclic loop are largely responsible for receptor selectivity. Structural features of free NPs in solution have not been investigated in details even if their characterization would be very useful in order to identify important aspects related to NPs function and receptor selectivity. In light of the above scenario, we carried out a 0.1μs molecular dynamics investigation of NPs with the aim of providing a high-resolution atomistic view of specific of their conformational ensemble in solution. Our results clearly indicate that NP receptor-bound conformations are not stable solution structure and that induced-fit mechanisms are involved in the formation of NP-NPR complexes. Moreover, in agreement with the current view on strictly relationship between protein dynamics and protein function and activity, it turns out that differences in activity and NPR specificity of CNP and ANP/BNP might be correlated to different amino acid composition of the cyclic loop, propensity to form β-sheet structures, flexibility patterns, dynamics properties and free conformations explored during the simulations.

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2010

Journal Article

L. Cipolla, Araújo, A. C., Bini, D., Gabrielli, L., Russo, L., and Dr. Nasrin Shaikh, “Discovery and Design of Carbohydrate-based Therapeutics”, Expert Opinion on Drug Discovery, vol. 5, pp. 721-737, 2010.[Abstract]


Importance of the field: Till now, the importance of carbohydrates has been underscored, if compared with the two other major classes of biopolymers such as oligonucleotides and proteins. Recent advances in glycobiology and glycochemistry have imparted a strong interest in the study of this enormous family of biomolecules. Carbohydrates have been shown to be implicated in recognition processes, such as cell–cell adhesion, cell–extracellular matrix adhesion and cell–intruder recognition phenomena. In addition, carbohydrates are recognized as differentiation markers and as antigenic determinants. Due to their relevant biological role, carbohydrates are promising candidates for drug design and disease treatment. However, the growing number of human disorders known as congenital disorders of glycosylation that are being identified as resulting from abnormalities in glycan structures and protein glycosylation strongly indicates that a fast development of glycobiology, glycochemistry and glycomedicine is highly desirable.Areas covered in this review: The topics give an overview of different approaches that have been used to date for the design of carbohydrate-based therapeutics; this includes the use of native synthetic carbohydrates, the use of carbohydrate mimics designed on the basis of their native counterpart, the use of carbohydrates as scaffolds and finally the design of glyco-fused therapeutics, one of the most recent approaches. The review covers mainly literature that has appeared since 2000, except for a few papers cited for historical reasons.What the reader will gain: The reader will gain an overview of the current strategies applied to the design of carbohydrate-based therapeutics; in particular, the advantages/disadvantages of different approaches are highlighted. The topic is presented in a general, basic manner and will hopefully be a useful resource for all readers who are not familiar with it. In addition, in order to stress the potentialities of carbohydrates, several examples of carbohydrate-based marketed therapeutics are given.Take home message: Carbohydrates are a rich class of natural compounds, possessing an intriguing and still not fully understood biological role. This richness offers several strategies for the design of carbohydrate-based therapeutics.

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2010

Journal Article

Dr. Nasrin Shaikh, L, C., L, G., D, B., and L, R., “An Essential Monosaccharide for Bacteria Viability”, Natural Product Reports, vol. 27, no. 11, pp. 1618 - 29, 2010.

2010

Journal Article

Dr. Nasrin Shaikh, Cipolla, L., Ferla, B. L., Airoldi, C., Zona, C., and Orsato, A., “Carbohydrate Mimetics and Scaffolds: Sweet Spots in Medicinal Chemistry”, Future Medicinal Chemistry, vol. 2, pp. 587-599, 2010.[Abstract]


Several glycoprocessing enzymes and glycoreceptors have been recognized as important targets for therapeutic intervention. This concept has inspired the development of important classes of therapeutics, such as anti-influenza drugs inhibiting influenza virus neuraminidase, anti-inflammatory drugs targeting lectin-sialyl-Lewis X interaction and glycosidase inhibitors against HIV, Gaucher’s disease, hepatitis and cancer. These therapeutics are mainly carbohydrate mimics in which proper modifications permit stronger interactions with the target protein, higher stability, better pharmacokinetic properties and easier synthesis. Furthermore, the conformational rigidity and polyfunctionality of carbohydrates stimulate their use as scaffolds for the generation of libraries by combinatorial decoration with different pharmacophores. This mini-review will present examples of how to exploit carbohydrates mimics and scaffolds in drug research.

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2010

Journal Article

L. Russo, Dr. Nasrin Shaikh, Cipolla, L., Nicotra, F., Riccardi, C., and Zanini, S., “Hydroxyapatite Three-dimensional Scaffold: Biofunctionalisation by Plasma Technology and Biological Evaluation”, Journal of Biotechnology, vol. 150, p. 202, 2010.

2010

Journal Article

L. Russo, Dr. Nasrin Shaikh, Cipolla, L., Nicotra, F., Quarto, R., and Giannoni, P., “C-type Natriuretic Peptide for Tissue Engineering Applications”, Journal of Biotechnology, vol. 150, p. 203, 2010.

2009

Journal Article

F. Nicotra, Cipolla, L., La Ferla, B., Airoldi, C., Zona, C., Orsato, A., Dr. Nasrin Shaikh, and Russo, L., “Carbohydrate Scaffolds in Chemical Genetic Studies”, Journal of Biotechnology, vol. 144, pp. 234 - 241, 2009.[Abstract]


Small molecules altering protein functions as inhibitors, agonists or antagonists, find application in systems biology enabling an analysis of the in vivo consequences of these alterations. In this context carbohydrates are ideal tools, not only because they are involved in a variety of recognition phenomena of biological relevance, but also because they are ideal scaffolds to generate libraries of bioactive compounds. Examples of design, synthesis and biological assays of different carbohydrate based inhibitors or protein ligands are reported. Exploiting NMR methods, the binding between a small molecules (inhibitor or ligand) and a protein can be detected, the affinity measured, and the interaction topology defined. This set of information is useful not only to clarify the mechanism of protein–ligand interaction, but also to improve the design of new inhibitors/ligands. The multifunctionality and the conformational rigidity of carbohydrates make this class of compounds the ideal scaffolds to generate libraries exploiting the combinatorial approach. An example of solid phase combinatorial synthesis of a library of 37 compounds is reported.

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Publication Type: Book

Year of Conference Publication Type Title

2013

Book

L. Cipolla, Russo, L., Dr. Nasrin Shaikh, and Nicotra, F., Materials Biofunctionalization for Tissue Regeneration, vol. 2. Polymeric Biomaterials, 2013.

Publication Type: Conference Proceedings

Year of Conference Publication Type Title

2012

Conference Proceedings

Dr. Nasrin Shaikh, Zaccheria, F., and Ravasio, N., “Supported metal oxides as green and eco-friendly solid acid catalysts for Friedel Crafts acylation ”, XVIII Congresso Nazionale DCI SCI. University of Florence, Florence-Italy, 2012.

2012

Conference Proceedings

Dr. Nasrin Shaikh, Zaccheria, F., and Ravasio, N., “Solid Acid Catalysts for Friedel Crafts Acylation”, EFCATS, Summer School. verbania-Italy, 2012.

2011

Conference Proceedings

Dr. Nasrin Shaikh, Russo, L., Cipolla, L., and Nicotra, F., “Design of Smart Biomaterials”, Joint Italian-Spanish workshop. Milan- Italy, 2011.

2010

Conference Proceedings

Dr. Nasrin Shaikh, L. Cipolla, R., and Nicotra, F., “Hydroxyapatite Functionalization by Bioorganic Molecules and its Biological Evaluation”, 18th International Conference on Organic Synthesis (ICOS-18). Bergen, Norway, 2010.

2010

Conference Proceedings

Dr. Nasrin Shaikh, Cipolla, L., and Nicotra, F., “Hydroxyapatite Three Dimentional Scaffolds:biofunctionalisation by Plasma Technology and Biological Evolution”, 14th International Biotechnology Symposium and Exhibition. Rimini-Italy, 2010.

2010

Conference Proceedings

Dr. Nasrin Shaikh, Cipolla, L., Russo, L., and Nicotra, F., “Biomolecules Synthesis and Functionalisation for Tissue Engineering Applications”, CINMPIS (consorzio interuniversitario nazionale“metodologie e processi innovativi di sintesi =Methods and processo f innovative synthesis). Sanbendetto del trento, Italy, 2010.

2009

Conference Proceedings

Dr. Nasrin Shaikh, Russo, L., Cipolla, L., and Nicotra, F., “Silanisation of Carbonate substituted Hydroxyapatite toward Covalent Biodecoration”, ESB(22nd European Conference on Biomaterials). Lausanne, Switzerland, 2009.

2009

Conference Proceedings

Dr. Nasrin Shaikh, Cipolla, L., Russo, L., and Nicotra, F., “Azidoalkyl and Propargyl Glycosides from Unprotected Monosaccahrides Towords Chemoselective Ligation”, European carbohydrate symposium (Eurocarb 15th). Vienna, Austria, 2009.

2009

Conference Proceedings

Dr. Nasrin Shaikh, Russo, L., Cipolla, L., and Nicotra, F., “Chemoselective ‘‘Glycosylation’’of Biomaterials”, European carbohydrate symposium (Eurocarb 15th). Vienna, Austria , 2009.

2009

Conference Proceedings

Dr. Nasrin Shaikh, Cipolla, L., Russo, L., and Nicotra, F., “Covalent Biofunctionalisation of hydroxyapatite scaffolds via plasma technology”, ESB(22nd European Conference on Biomaterials). Lausanne, Switzerland, 2009.

2009

Conference Proceedings

Dr. Nasrin Shaikh, Cipolla, L., Russo, L., and Nicotra, F., “Carbonated Hydroxyapatite iofunctionalisation with Carbohydrates”, ESB(22nd European Conference on Biomaterials). Lausanne, Switzerland, 2009.

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