Deepak O. M. currently serves as Assistant Professor in Chemistry, Department of Sciences, School of Engineering, Coimbatore Campus. His areas of research include Computational Chemistry, Solid-State NMR Spectroscopy.


Publication Type: Journal Article

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Journal Article

A. Ma HimaVyshnavi, Anand, C. Lb, Deepak, O. Mc, and P. K. Krishnan Namboori, “Evaluation of colorectal cancer (CRC) epidemiology a pharmacogenomic approach”, Journal of Young Pharmacists, vol. 9, pp. 36-39, 2017.[Abstract]

Background: The population-wise variation in proneness of Colorectal Cancer (CRC) has been studied in the manuscript. A population wise analysis of responsiveness towards colorectal cancer is carried out with genetic, epigenetic, metagenomic and environmental factors associated with APC mutation mainly responsible for CRC among eight different populations. Methods and Material: The APC mutation has been obtained using the 'human gene mutation database-HGMD' and the 'international cancer genome consortium-ICGC' Data Portal. The epigenetic factors affecting colon cancer have been identified through EpiGRAPH tool. The 'human oral microbiome database (HOMD) and 'comparative toxicogenomics database (CTD)' are used to find the metagenomic factors affecting CRC. Results: Variants of APC gene from the selected ethnic classes chosen from Argentina, France, Germany, India, Poland, Romania, UK and USA were characterized, where the chromosome positions 112102966-112177228 are found to be affected. It has been found that among epigenetic factors: chromosome organization, population variation, and evolutionary history are highly promising features for the prediction of DNA methylation. It has been found that consumption of linoleic acid, oleic acid, and lauric acid play a major role in preventing CRC. Conclusions:The chromosome positions 112102966-112177228 are found to be the most prone region for APC mutation. Chromosome organization, population variation, and evolutionary history are highly promising epigenetic features for the prediction of DNA methylation and further mutation. The consumption of spices, coconut oil, fish (in coastal areas), dairy products and reduced intake of red meat may be the reasons for less incidence rate of CRC among the Indian population.

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Publication Type: Conference Proceedings

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Conference Proceedings

A. G. Warrier, Barani, D. M., Deepak, O. Mc, P. K. Krishnan Namboori, Sairam, G. L., and S Surendran, S., “Biomolecular motor proteins as targets for cancer treatment- a computational study”, IEEE Tech Symbosium. IEEE, IIT, Kharagpur, pp. 17 - 20, 2010.[Abstract]

Molecular motors carry out essential functions in the cell and form the basis of many important biological processes. A distinctive property of molecular motors is their ability to convert energy from ATP upon hydrolysis. These motors are able to bind and move along cytoskeletal filaments. The protein analysis performed revealed the conserved regions and the active sites of these proteins which can be used for ligand designing for effectively targeting of the drugs. Stability, aliphatic index, hydropathy index and half life of these proteins were also calculated. From the computational modeling and simulation studies, interaction potential energy of each of the motor proteins has been computed. The interaction potential energy and Vander Waals energy were found to be negative for all the motor proteins. The analysis described in this paper points out several properties of the molecular motors and thus provides information on roles of these chemicals in various body disorders. Molecular motors involved in cell division can be effectively targeted by the drugs against cancer.

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NIRF 2017