Qualification: 
MSc
pradeeshbabu@am.amrita.edu

Pradeesh Babu currently serves as a Junior Research Fellow at Sanitation Biotechnology Lab, School of Biotechnology, Amrita Vishwa Vidyapeetham

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2017

Journal Article

Chandni P, Amrita Salim, Archana P. V., Pradeesh Babu, Dr. Bipin G. Nair, Madhavan, A., and Dr. Sanjay Pal, “Characterization of the bacteriophages binding to human matrix molecules.”, International Journal of Biological Macromolecules, 2017.[Abstract]


Recent literature has suggested a novel symbiotic relationship between bacteriophage and metazoan host that provides antimicrobial defense protecting mucosal surface by binding to host matrix mucin glycoproteins. Here, we isolated and studied different bacteriophages that specifically interact with human extracellular matrix molecules such as fibronectin, gelatin, heparin and demonstrated their potency for protection to host against microbial infections. We showed that subpopulations of bacteriophages that work against clinical isolates of Escherichia coli can bind to pure gelatin, fibronectin and heparin and reduced bacterial load in human colon cell line HT29. The bacteriophages were characterized with respect to their genome sizes, melting curve patterns and host tropism (cross-reactivity with different hosts). Since, the bacteriophages are non-toxic to the host and can effectively reduce bacterial load in HT29 cell line their therapeutic potency against bacterial infection could be explored.

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Publication Type: Conference Paper

Year of Publication Publication Type Title

2017

Conference Paper

Pradeesh Babu, Poornendu, S. J., Amrita Salim, Madhavan, A., Dr. Bipin G. Nair, and Dr. Sanjay Pal, “Resazurin based redox dye as an indicator for monitoring wastewater biological activity”, in Innovative Strategies for Sustainable Water Management (ISSWM-2017), Punjab, India, 2017.

Faculty Research Interest: 
207
PROGRAMS
OFFERED
6
AMRITA
CAMPUSES
15
CONSTITUENT
SCHOOLS
A
GRADE BY
NAAC, MHRD
8th
RANK(INDIA):
NIRF 2018
150+
INTERNATIONAL
PARTNERS