Qualification: 
M. Pharm.
remyareghu@aims.amrita.edu

Remya Reghu joined as lecturer in the Department of Pharmacy Practice at Amrita School of Pharmacy in February 2011. She completed her B. Pharm from Department of Pharmaceutical Sciences, Cheruvandoor campus, M.G University and M. Pharm from Amrita School of Pharmacy, Kochi. She has more than 20 international and 5 national publications to her credit. Now she is actively involving and monitoring in the various clinical activities of Pharm D. and M. Pharm students at Amrita hospital. She has also guided various B. Pharm, M. Pham and Pharm D projects. Her main areas of interests are Pharmacovigilance, Pharmacoeconomics and Medication Therapy Management.

Publications

Publication Type: Journal Article

Year of Publication Title

2019

R. Reji, Thomas, A., Rajappan, A., Jospeh, S., and Remya Reghu, “A Prospective Study to Analyse the Agreement between Empirical Antimicrobials used in Infective Endocarditis and Culture Sensitivity Reports”, Journal of Clinical and Diagnostic Research, vol. 13, 2019.[Abstract]


Introduction: Infective Endocarditis (IE) is defined as a microbial infection of the heart valve or the mural endocardium. Annually the incidence of IE is between 2 and 6 per 100,000 individuals. The diagnostic techniques for IE and selection of empiric antibiotics remain a big challenge in the light of changing microbiological spectrum for IE.

Aim: To identify the risk factors of IE, to identify the specific pathogens involved, the empirical therapy provided and to analyse the agreement between the empirical therapy and the culture sensitivity reports.

Materials and Methods: The study was a non experimental, descriptive and prospective type of study involving patients diagnosed with IE and fitting into the inclusion and exclusion criteria. This study was conducted on patients admitted under Cardiology department of Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India. Information on risk factors, empirical antibiotic therapy, culture sensitivity report and definitive therapy in IE were collected by accessing the hospital information system. Statistical analysis has been carried out using Chi-square test.

Results: The most common non predisposing and predisposing riskfactors were diabetes mellitus 30% and rheumatic heart disease 35% respectively. The most commonly identified organisms in blood cultures were Streptococcus and Staphylococcus species. Majority of the patients with native 46% and prosthetic endocarditis 57% had undergone a change in their therapy according to the culture sensitivity report.

Conclusion: Optimal empirical antibiotic selection is essential in treating IE because after the culture report, altering antibiotics may lead to increased chances for unintended antibiotic resistance. Isolation of atypical pathogens like Pseudomonas aeruginosa and Mycobacterium abscessus implies changes in the microbiological spectrum for this disease.

More »»

2019

D. S. Raju, Sugunan, A., Dr. Pavithran K., Arun Philip, and Remya Reghu, “Chemoport-related Fungemia Caused by Trichosporon asahii.”, J Pediatr Hematol Oncol, 2019.[Abstract]


Trichosporon asahii is a rare opportunistic fungal pathogen that causes fatal systemic infection in immunocompromised patients. Neutropenia developing due to malignancies is an important risk factor for fungal infection. Invasive infections due to T. asahii can be divided into disseminated and localized forms. The disseminated form is more common and usually occurs in neutropenic patients. The patient typically has an acute febrile illness that progresses rapidly to multiorgan failure. Here, we are presenting a case of fungal sepsis by invasive T. asahii in a 1-year-old child with Wilms Tumor. To the best of our knowledge, this is the first time that fungal sepsis due to T. asahii has been reported in a Wilms tumor patient. The incidence of rare invasive fungal infections is increasing in immunocompromised patients in whom management becomes difficult due to their heterogenous antifungal susceptibility pattern and intrinsic resistance to the standard antifungal agents that are routinely given. The patient was admitted with high spiking fever, and his laboratory investigations suggested neutropenia. T. asahii was isolated from the blood culture, for which he was started on inj. voriconozole. After 14 days of treatment, the fungus was cleared out from the patient's blood.

More »»

2017

B. Vincent, James, A., Syamaprasad, T. V., Reji, R., and Remya Reghu, “A case report on Wilson’s disease-induced liver cirrhosis”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 113-114, 2017.[Abstract]


Wilson’s disease (WD) is an inherited autosomal genetic abnormality which results in impairment in cellular copper transport. Overtime, this may lead to liver cirrhosis. The main focus of this case is to shows the importance of taking a medical history. Here, we discuss a case of a 35-year-old male diagnosed with WD-induced liver cirrhosis and portal hypertension. He was physically very weak. Since the same genetic abnormality was the reason for the death of his sibling which was not considered while taking the medical history of this patient, this led to a late diagnosis of 4 years while the patient’s condition became worst. Herein, we report a case that provides an insight to medical professionals about taking proper medical history of patients © 2017 The Authors.

More »»

2017

A. James, Reji, R., Vincent, B., Mani, N., and Remya Reghu, “Febrile infection-related epilepsy syndrome: A rare case presentation”, Asian Journal of Pharmaceutical and Clinical Research, vol. 10, pp. 6-7, 2017.[Abstract]


Febrile infection-related epilepsy syndrome is characterized by super refractory status epilepticus that is resistant to conventional antiepileptic drugs. This case report critically analyses the treatment options adopted in a hospital to manage this syndrome. Despite the aggressive efforts that were taken, the patient succumbed to the complications of the illness and side effects of the treatment strategies adopted. This shows that the treatment options currently available are in adequate, so an intensive research in the area of pathogenesis of status epilepticus is required to frame treatment strategies that can bring out better outcomes. © 2017 The Authors.

More »»

2016

Remya Reghu, PC, S., Das, A. R., M, N. C., Joseph, T., K, A. Kumar, Venugopal, A., P, S. T., and P., Gkumar K., “A study on safety and efficacy of tolvaptan in hyponatremic patients with urinary sodium loss.”, International Journal of Pharmaceutical Sciences Review and Research , vol. 38, no. 1, pp. 115-119, 2016.[Abstract]


The aim of the study was to find out drug related problems with a special focus on ADRs during Tolvaptan administration and also to assess the change in serum (Na+) levels, improvement in physical and mental functioning of patients before and after Tolvaptan administration. A total of 74 patients prescribed with Tolvaptan were selected during the study period and their data relevant to the study was collected which includes urine sodium, serum sodium, serum osmolarity, urine osmolarity, liver function test, renal function test, was collected. 12 –item short-form (SF-12) General Health Survey Questions and Glasgow coma scale were used for mental and physical functioning assessment after drug entry. Adverse event that occurred includes Thirst (21 patients), Dry mouth (7 patients), and Hyperkalemia (7 patients) and all events was confirmed using Naranjo probability ADR scale in which causality for majority of adverse event was probable (5-9). Out of 74, 15 patients who were admitted directly to the intensive care unit (ICU), 14 patients (93.3%) were shifted within 3days of treatment with Tolvaptan to the ward and remaining one was shifted on day 5. The primary efficacy outcome in the study was change in average serum sodium concentration baseline to day 3, 5, and 7. The patient on Tolvaptan exhibited a highly significant improvement in serum sodium from base line to 7th day. The effect of Tolvaptan on SF12 General Health Survey was examined and a remarkable increase in Physical Component Score (PCS) and Mental Component Score (MCS) was found after treatment. The vasopressin receptor antagonist, Tolvaptan was superior in raising and maintaining serum sodium (Na+) in patients with hyponatremia with minimal side effects and can be safely administered without any major concerns at a dose of 15mg OD for 7 days

More »»

2016

Remya Reghu, Dr. Umadevi P., Sasankan, V., Puthur, S., and Jose, J., “A microbiological study of diabetic foot ulcer in a south Indian tertiary care hospital”, International Journal of Pharmaceutical Sciences Review and Research, vol. 37, pp. 167-170, 2016.[Abstract]


Diabetic foot ulcer is an important complication among diabetic patients and is a significant risk factor for lower extremity amputation. Knowledge of microbes that cause infections will be helpful to determine proper empirical antibiotic therapy. Thus, this retrospective study was undertaken in 150 diabetic patients with foot ulcers who were admitted in the Department of Endocrinology. Patient data relevant to the study was collected using a standard data collection form. Details of organisms isolated and susceptibility pattern were collected from microbiology department. A total of 273 pathogens were identified from 150 patients with an average of 1.8 organisms per patient. Among 150 cases, 65 (43.3%) had monomicrobial infection and 85 (56.7%) had polymicrobial infection. Both gram positive and gram negative organisms caused diabetic foot infections and this study showed a preponderance of gram negative organisms. Among the 273 pathogens, 150 (54.9%) were gram negative bacteria, 104 (38.1%) were gram positive bacteria and 19 (7.0%) were fungi. Enterococcus faecalis and Escherichia coli (12.1% each) were the most common pathogens isolated. Vancomycin, teicoplanin, tigecycline and linezolid were found to be the highly effective against gram positive organisms, whereas amikacin and colistin were most effective against gram negative organisms. The high prevalence of polymicrobial infection highlights the need for combined antimicrobial therapy for initial management. Effective planning of therapy is very essential for preventing the emergence of drug resistant organisms. © 2016, Global Research Online. All rights reserved.

More »»

2015

Remya Reghu, Keerthana, P. C. Sai, A. Das, M, N. C., Joseph, T., Meenu Vijayan, and Roshni P. R., “A case report on carbimazole induced myositis”, International Journal of Pharmaceutical Sciences Review and Research, vol. 32, no. 1, pp. 268-269, 2015.[Abstract]


Carbimazole is an anti-thyroid drug commonly used to treat hyperthyroidism. Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T 4. Here we are presenting a case report of carbimazole induced myositis © 2015, Global Research Online. All rights reserved.

More »»

2014

Roshni P. R., Thomas, N. R., Remya Reghu, and Meenu Vijayan, “Application of pharmacogenomics in health care”, International Journal of Pharmaceutical Sciences Review and Research, vol. 26, pp. 131-133, 2014.[Abstract]


Pharmacogenomics is the study of how genetic factors relate to inter-individual variability of drug response. With the initiation of Human Genome Project on 1991, it will have an important effect on the development and utilization of drug which is based on the person's genotype that ensure the rational use of medicine. The pharmacokinetic and pharmacodynamic characters of the drug may influenced by various genetic factors, so the effect of a drug may vary from person to person. Genetic polymorphism of single gene affect a numerous drug metabolizing enzymes, thus leads to altered drug metabolism and produce adverse effects or inefficiency. It has relevance in case of population carries genetic variation-polymorphism that may alter the drug response such as in the case of warfarin. A reduction in warfarin metabolism due to genetic polymorphism in CYP2C9 system may explain the increased warfarin response and bleeding episodes in some patients. The impact of genetic polymorphism has bee also important in case of drugs which are metabolized through CYP2D6 subfamily, such as codeine, nortriptyline, metoprolol, simvastatin, abacavir, carbamazepine, selective serotonin reuptake inhibitors and tamoxifen. This review is mainly focused on the importance of pharmacogenomic testing for certain drugs.

More »»

2012

H. K. V, R, R., M, M., and Remya Reghu, “Role of Omega 3 Fatty Acids in Treatment of Cardovascular Disorders,”, Journal of Pharmacy Research, vol. 5, 11 vol., pp. 5140 - 5143, 2012.

2012

K. V. Harikrishnan, Rajasree, R., Thomas, N., and Remya Reghu, “Study of prescription pattern and insulin treatment in type 2 diabetic patients”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 4, pp. 328-330, 2012.[Abstract]


This project work was an observational prospective study carried out in a tertiary care hospital for studying the prescription pattern and insulin treatment in diabetic patients. The study also includes the analysis of patient information and comorbid conditions. The objectives were to determine the patient information, prescription pattern and treatment of Type 2 DM using insulin. First select 50 patients those who are willing to participate in the study according to the inclusion and exclusion criteria. The patient information such as MRD no., age, sex, duration of hospital stay, comorbid conditions, patient medication profile and details of insulin treatment are collected according to the disease condition. The data was tabulated and done the statistical procedure. In a total of 50 patients, 36 (72%) patients are male and the remaining 14(28%) are females. From prescription pattern analysis it is found that 62.2% of the total medications are prescribed in brand name and 37.8% was prescribed in generic name. From the medication profile of the patients it was found that 43 patients (86%) are treated with insulin. It is observed from the study that insulin is commonly used in all the type 2 diabetes mellitus patients. Human mixtard and human atrapid are the two common classes of insulin which is used for the treatment. This article may helpful for finding out the importance of insulin in type 2 DM. This article also shows the relation between diabetes and other comorbid condition and how the risk increases along with the number of medication.

More »»

2011

Remya Reghu and Emmanuel James, “Epidemiological profile and treatment pattern of vitiligo in a tertiary care teaching hospital”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 3, pp. 137-141, 2011.[Abstract]


The objective of the present study was to assess the prevalence, precipitating factors, clinical features and management pattern of vitiligo patients. An observational, cross sectional descriptive study was carried out for a period of five months from a study population of 6250 outpatients who visited the dermatology department of a tertiary care hospital. The prescriptions of the individual patients were collected to assess the therapeutic management pattern. Prevalence of vitiligo was found to be 1.3%. The mean age at onset of the disease was 29.6 ± 20.6 years. 18.8% of the patients had a family history of vitiligo. Lower limbs (42.5%) followed by face (27.5%) were the most affected parts. Major precipitating factor was found to be physical trauma (18.8%). Thyroid disorder was the most common autoimmune disorder observed (21.3%). Vitiligo vulgaris was the common clinical type (53.7%) followed by focal vitiligo (18.8%), acrofacial vitiligo (13.8%), segmental vitiligo, etc. Topical tacrolimus (68.8%), topical corticosteroids (53.7%), and topical psoralen (48.8%) were the first line treatments used in the study center. Systemic steroid pulse therapy was used in progressive vitiligo patients and the noted adverse effects of the treatments were gastric irritation (11.3%) and weight gain(7.5%). Autologous melanocyte transplantation(5%), epidermal suction blister grafting (2.5%) and narrow band ultra viloet B phototherapy (27.5%) were other treatment modalities used. Similar studies covering large number of patients are needed to confirm our findings.

More »»

Publication Type: Conference Paper

Year of Publication Title

2012

A. Sivadas, S., S., and Remya Reghu, “A Survey About the Leading Cause of Chronic Liver Diseases in a by Tertiary Care Hospital”, in 64th Indian Pharmaceutical Congress, SRM university, 2012.

2012

Roshni P. R., Remya Reghu, James, E., and Meenu Vijayan, “Study of Cardiovascular Risk Factors in Diabetic Patients in a Tertiary Care Teaching Hospital”, in 64th Indian Pharmaceutical Congress (selected as Best Paper), SRM university, Chennai, 2012.

2012

Remya Reghu, Meenu Vijayan, and Roshni P. R., “A Survey on Prescribing Mode of Antibiotics and NSAIDs in Communicable Diseases Especially Chikungunya”, in 64th Indian Pharmaceutical Congress (selected as Best Paper), SRM university, Chennai, 2012.

Faculty Research Interest: