Qualification: 
Ph.D, M. Pharm.
Email: 
sathyanarayanans@aims.amrita.edu

Dr. Sathianarayanan joined as lecturer in the Department of Pharmaceutical Chemistry at Amrita in February 2007. He completed his B. Pharm. and M. Pharm. from Dr. M G R Medical University, Chennai. He received his Ph. D. in Pharmacy from Karpagam University, Coimbatore.

Dr. Sathianarayanan's interests broadly include Semi-synthetic, Synthetic and Phytochemical Analysis. He has a strong academic background and extensive research experience with specialization in isolation and characterization of biologically active compounds. He has knowledge in docking studies, experimental pharmacology and handling of animals like rat, mice and rabbit to screen various pharmacological action.

Currently, he is involved in the Study of Isolation and Characterization of Bioactive Compounds from Herbs and Marine Organisms and Derivatization of Phytoconstituents, including the design, synthesis and development of bioactive heterocyclic compounds for the treatment of infectious diseases, cancer and immune related disorders. It is hoped that this novel approach will help a newer drug development with safety and efficacy.

He received a major funded project from Ministry of Earth Sciences of Rs 75.60 lakhs for the study titled High Through Put Screening of Biological Activity of Extracts from Deep Sea Marine Organisms. The Kerala State Council For Science, Technology and Environment has also funded for the Study - Synthesis of some Novel Scaffold for Anti-Prostate Cancer.

A text book titled Pharmaceutical Analytical Chemistry authored by Dr. Sathianarayanan was published by Birla Publications Pvt. Ltd, New Delhi. The book mainly focuses on the needs of undergraduate and postgraduate pharmacy students. It explains the science and application of modern and traditional techniques for the analysis of pharmaceutical products.

In his capacity as guide, he is mentoring B. Pharm. and M. Pharm. Thesis Projects some of which include:

  1. Phytochemical investigation and various pharmacological evaluation of Andrographis paniculata and Swertia chirayita.

  2. Phytochemical investigation and pharmacological screening of Ventilago madraspatana as an immunomodulator.

  3. Insilico design and synthesis of some novel Isatin and Quinazoline derivatives against mammary carcinoma.

  4. Design, synthesis and biological evaluation of anti-prostate cancer agents.

  5. Phytochemical and pharmacological screening of Wrightia tinctoria.

  6. Anthelmintic, antioxidant and immunomodulatory activity of methanolic extracts of Wrightia tinctoria leaves.

  7. Phytochemical screening and anticancer activity of Indigofera tinctoria.

  8. Synthesis, anticancer activity and QSAR analysis of substituted derivatives containing Indole moiety.

  9. In-vitro cytotoxic and antimicrobial activity of microwave assisted synthesized Isatin derivative.

  10. Insilico design and molecular docking studies of PDE-4 inhibitors for the treatment of psoriasis using some new Andrographolide, Isatin and Emodin derivatives.

  11. Priliminary phytochemical investigation and invitro anti-inflammatory activity of Sargassum wightii (Greville).

  12. Insilico design and synthesis of novel anti-inflammatory agents.

  13. Anti oxidant and cytotoxic activity of deep sea marine organism Hetractic magnifica.

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2017

Journal Article

E. S, R, N. T., K, R. V., Baranwal, G., Biswas, R., R, J., and Dr. S. Sathianarayanan, “Fucoidan coated ciprofloxacin loaded chitosan nanoparticles for the treatment of intracellular and biofilm infections of Salmonella.”, Colloids Surf B Biointerfaces, vol. 160, pp. 40-47, 2017.[Abstract]


Salmonella infections and their gallstone associated biofilm infections are difficult to treat due to poor penetration of antibiotics into the intracellular compartments of macrophages and within biofilms. Here we developed ciprofloxacin loaded chitosan nanoparticles (cCNPs) and fucoidan (Fu) coated cCNPs (Fu-cCNPs). Characterizations of these nanoparticles were carried out using Dynamic Light Scattering‎, Transmission electron microscopy and Fourier transform infrared spectroscopy. The prepared cCNPs and Fu-cCNPs have the size range of 124±7nm and 320±18nm, respectively. Both nanoparticles were found to be non-hemolytic and cytocompatible. In vitro sustained release of ciprofloxacin was observed from both cCNPs and Fu-cCNPs over a period of 2 weeks. The antimicrobial activity of cCNPs and Fu-cCNPs was tested under in vitro and in vivo conditions. The intracellular anti-Salmonella activity of Fu-cCNPs was 2 fold higher than cCNPs and 6 fold higher than ciprofloxacin alone. Fluorescence microscopic images confirmed enhanced delivery of Fu-cCNPs than the cCNPs within the intracellular compartment of macrophages. Both cCNPs and Fu-cCNPs are found to be equally effective in dispersing Salmonella Paratyphi A gallstone biofilms. The in vivo antibacterial activities of Fu-cCNPs were superior to cCNPs which we have validated using Salmonella Paratyphi A infected Drosophila melanogaster fly model. Our overall results showed that (1) Fu-cCNPs are more effective in eradicating Salmonella infections than cCNPs; (2) both cCNPs and Fu-cCNPs were equally effective in dispersing Salmonella gallstone biofilms.

More »»

2017

Journal Article

S. Pillarisetti, Maya, S., Dr. S. Sathianarayanan, and Jayakumar, R., “Tunable pH and redox-responsive drug release from curcumin conjugated γ-polyglutamic acid nanoparticles in cancer microenvironment”, Colloids and Surfaces B: Biointerfaces, vol. 159, pp. 809 - 819, 2017.[Abstract]


Abstract Tunable pH and redox responsive polymer was prepared using γ-polyglutamic acid (γ-PGA) with linker 3-mercaptopropionic acid (3-MPA) (γ-PGA_SH) via oxidation to obtain redox responsive disulfide (γ-PGA_SS) backbone and adipic acid dihydrazide (ADH) (γ-PGA_SS_ADH) with hydrazide functional group for pH responsiveness. Further curcumin (Cur) was conjugated through hydrazone bond of the γ-PGA_SS_ADH via Schiff base reaction to obtain (γ-PGA_SS_ADH_Cur). The prepared systems were characterized by Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, Electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-Qq-TOF-MS/MS) and Solid state nuclear magnetic resonance (SS NMR) techniques. γ-PGA_SS_ADH_Cur formed self-assembled core shell nanoparticles (NPs) in existence of stabilized aqueous medium. γ-PGA_SS_ADH_Cur NPs maintained its stability in physiological condition. NPs tunable Cur release and cytotoxicity were observed for γ-PGA_SS_ADH_Cur NPs in both acidic and redox conditions mimicking the cancer microenvironment. γ-PGA_SS_ADH_Cur NPs uptake study showed via endocytosis mechanism resulted in the lysosomal entrapment of these NPs within the cell. γ-PGA_SS_ADH_Cur NPs exhibited a dual stimuli responsive drug delivery and can be used as a smart and potential drug delivery system in cancer microenvironment.

More »»

2017

Journal Article

Dr. S. Sathianarayanan, Varghese, A., Gavani, U., Abraham, S., and Parambi, D. Grace Thom, “Phytochemical Screening and Antimicrobial investigation of Typha angustifolia linn.”, International Journal of Chemical Science, vol. 7, pp. 1905-1910, 2017.

2016

Journal Article

Dr. S. Sathianarayanan, Jose, Ab, Balasubramanian, Ra, Thomas, Dd, Balakrishnan, Aa, and Aiyalu, Rc, “Alcoholic extract of Wrightia tinctoria leaves and isolates there of afford DNA protection in post irradiated Sprague Dawley rats”, Journal of Young Pharmacists, vol. 8, pp. 398-405, 2016.[Abstract]


Objective: The current study investigates the potential of alcoholic extract of Wrightia tinctoria leaves and its isolates in repairing the DNA damage induced by gamma radiation. Methodology: The ethanolic extract of Wrightia tinctoria (EEWT) the leaves was subjected to in vitro anti oxidant assay by DPPH radical scavenging and hydrogen peroxide scavenging methods. He EEWT was investigated to the Micronucleus assay, spleen colony assay and comet assay in Sprague Dawley rats wherein DNA damage had already been induced by irradiation. Results: The ethanolic extract of Wrightia tinctoria leaves having good antioxidant activity. In the micronucleus assay, a 2 Gy quantum of whole-body gamma radiation significantly enhanced the levels of micronucleated reticulocytes and this induction was substantially reversed in the extract treatment group. Results of the spleen colony assay pointed to the extract's ability to enhance the recovery of the hematopoietic system, in a dose-dependent manner, following 6 Gy gamma irradiation. The decrease in cellular repair index due to enhanced DNA repair was evident from the comet assay parameters. Moreover, the isolates from ethanolic extract of Wrightia tinctoria, when imperiled to DNA protection by in vitro gamma radiation method in plasmid pBR322 DNA, abetted DNA repair at higher dose. Conclusion: The DNA protection afforded is likely attributable to free radical scavenging properties along with a potential for regenerating the immune system through repair of post irradiated DNA. © 2016, EManuscript Services. All rights reserved.

More »»

2016

Journal Article

Dr. S. Sathianarayanan, Prasad, N., Josna, K. Joy, S, S. Nair, Ashokan, A. Asha, and T.S, S., “In-silico docking studies of coumarin derivatives as capsase * and PDE4 Antagonist. ”, Research Journal of Pharmacy and Technology, vol. 9, no. 12, pp. 2199-2204., 2016.

2015

Journal Article

Dr. S. Sathianarayanan, S, S. M., Kumar, R. S., V, S., Menon, S. V., Mohan, S., .T.S, S., Asha Asokan Manakadan, and Suja, S., “A Computational approach for identification of Phytochemicals for targeting and optimizing the inhibitors of Heat shock proteins”, Research Journal of Pharmacy and Technology., vol. 8, no. 9, pp. 1199- 1204, 2015.[Abstract]


Pancreatic cancer is a class of disease characterized by uncontrolled cell growth that begins in the pancreas. Heat shock proteins (Hsps) are chaperone proteins that on inhibition can prove to be effective in pancreatic cancer treatment. In cancer cells, Hsp90 significantly displays a proliferative potential of the malignant cells, so the inhibition of the protein can prove to be valuable to combat pancreatic cancer. Computer Aided Drug Designing (CADD) was instrumental to find out the effective constituent among the 35 plant sources selected. The Phytochemicals used for the present study were Curcumin, Allicin, Pinene, Tetrahydrocannabinol, Astragalin, Arginine, Scopoletin, Baicalin, Stylopine, Carvacrol, Quercetin, Thymol, Guaiaretic acid, Coumarin, Chlorogenic acid, Taraxacin, Ascorbic acid, Protocatechuic acid, Withaferin A, Triptolide, Ursolic acid, Cucurbitane, Thymoquinone, D-Carvone, Eugenol, Ellagic acid, Lapachol, Genistein, Emodin, Chelidonine, Caffeine, Catechin, Geraniol, Myrcene and Niacin. The preliminary studies such as the Primary and Secondary structure analysis of the protein were carried out. Molecular property based on Lipinski rule of 5, bioactivity parameters as well as Protein-Ligand Dynamic interaction were analyzed to determine the drug likeness of the ligands with the protein 4L94. The results of the in silico docking analysis indicate the selection of natural compounds such as Cucurbitane, Myrcene and Pinene as they elicited significant binding interaction in inhibiting Heat shock proteins for targeting pancreatic cancer which was comparable with that of the standard drug Gemcitabine. Further in vivo studies may be carried out to prove the same.

More »»

2012

Journal Article

E. Varghese, Dr. Leena K. Pappachen, and Dr. S. Sathianarayanan, “Isolation and evaluation of antimicrobial properties of isolated phytoconstituents of fruits of Helicteres isora Linn.”, Research Journal of Pharmaceutical, Biological and Chemical Sciences, vol. 3, pp. 959-964, 2012.[Abstract]


Helicteres isora linn, an ayurvedic herb, is distributed widely in forest throughout India. Almost its all parts are used traditionally. The fruits are useful in diarrhoea, dysentery, wounds, ulcers, hemorrhages and diabetes. The fruit after collection, authentication and drying, was extracted with petroleum ether, chloroform, methanol and water using soxhlet extractor. The present study was aimed to isolate the constituents and evaluate the antimicrobial properties of isolated constituents of methanolic extract of fruits of Helicteres isora linn. Isolation of alkaloids, flavonoids and phenolic compounds was done by using HPTLC technique. The invitro antimicrobial activities of methanolic extract, isolated alkaloids, flavonoids and phenolic compounds were investigated against Escherichia coli, Pseudomonas aeruginosa, Salmonella abony and Staphylococcus aureus by cup-plate diffusion method. The methanolic extract showed activity against Escherichia coli, Pseudomonas aeruginosa, Salmonella abony and Staphylococcus aureus., isolated phenolic compounds against Escherichia coli, Pseudomonas aeruginosa and Salmonella abony., isolated flavonoids against Pseudomonas aeruginosa and Staphylococcus aureus., and isolated alkaloids against Escherichia coli and Staphylococcus aureus. Minimum inhibitory concentration was determined by liquid broth method. Minimum inhibitory concentration of methanolic extract against Pseudomonas aeruginosa was found to be 10μg/ml and that against Staphylococcus aureuswas found to be 8μg/ml.

More »»

2012

Journal Article

Dr. S. Sathianarayanan and Rajasekharan, A., “Immunomodulatory Activity of ethanolic extract of Wrightia tinctoria Leaves”, International Journal of Pharmacy and Pharmaceutical Sciences., vol. 4, pp. 251 - 254, 2012.

2012

Journal Article

Dr. S. Sathianarayanan, Jose, A., N, F. K., ,, S., S. K., and , “Immunomodulatory Activity of methanolic extract of Wrightia tinctoria Leaves”, International Journal of Advanced Pharmacology and Toxicology, vol. 13, no. 2, pp. 39 - 46, 2012.

2012

Journal Article

Dr. S. Sathianarayanan, Jose, A., Rajasekharan, A., George, R. Mary, and Chittethu, A. B., “ Evaluation of Protective Effect of Luffa acutangula Extract against Bilateral Carotid artery occlusion (BCAO) induced strock in rats”, Indian Journal of Pharmaceutical Science and Research, vol. 2, no. 1, pp. 1 - 6, 2012.

2011

Journal Article

E. Varghese, Dr. S. Sathianarayanan, Gopal, R. V., Nair, A., Chittethu, A. B., and Anson, T. A., “Aticancer activity of chloroform extract of Helicteres ISORA”, International Journal of Pharmacy and Technology, vol. 3, pp. 2560-2564, 2011.[Abstract]


Helicteres isora belongs to the family sterculiaceae is an ayurvedic herb.it is distributed widely in forest throughout india and are commonly known as east india screw tree spi_sup1spii_sup. Is a medicinally important sub-deciduous shrub or small tree.almost all parts of the plant are used in traditional medicinal system for curing various diseases. its fruit,Root and bark possess significant antidiabetic. Antioxidant,Antimicrobial and hypolipidemic activity. the fruit of helicterusisora after collection,Authentication and drying was extracted with chloroform using soxhlet extractor.the present study was aimed to determine the preliminary phytochemical evaluation and cytotoxicity study of the chloroform extract of helicteres isora on MCF - 7 cell line (human breast cancer) by MTT assay method. the preliminary phytochemical evaluation showed the presence of carbohydrates,Flavonoids,Tannins and alkaloidsspi_sup2spii_sup.its cytotoxic evaluation showed a potent action against to MCF - 7 (michigan cancer foundation - 7) cell line. More »»

2011

Journal Article

Dr. S. Sathianarayanan, Jose, A., ,, George, R. Mary, and P, A., “Chittethu. Diuretic activity of aqueous and alcoholic extracts of Wrightia tinctoria”, International Journal of Phytopharmacology, vol. 2, no. 1, pp. 7 - 8, 2011.

2011

Journal Article

Dr. S. Sathianarayanan, Vargheese, E., Gopal, R. Vijaya, Nair, A., Chittethu, A. B., and T.A, A., “Anticancer activity of chloroform extract of Helisteres isora”, IJPT, vol. 3, no. 2, pp. 2560-2564, 2011.

2011

Journal Article

Dr. S. Sathianarayanan, Chittethu, A. B., .Sathianarayanan, S., Nair, A., Varghese, E., and Gopal, R. Vijaya, “Preliminary Phytochemical Screening and cytotoxic activity of Ethenolic Extract of Ventilago Madraspatana ”, Int. J. Pharmacol. Bio.Sci. , vol. 5, no. 2, 2011.

2011

Journal Article

Dr. S. Sathianarayanan, K.Shankar, B., Abraham, S., George, R. Mary, and Jose, A., “Pharmacoeconomics:Need for Introduction in Indian Healthcare”, Indian Journal of Hospital Pharmacy , vol. 48, 2011.

2010

Journal Article

T. B. Lima, Suja, A., Jisa, O. J., Dr. S. Sathianarayanan, and Remya, K. S., “Hepatoprotective activity of LIV-first against carbon tetra chloride-induced hepatotoxicity in albino rats”, International Journal of Green Pharmacy, vol. 4, pp. 71-74, 2010.[Abstract]


Liver toxicity is a major health problem of worldwide proportions. Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. In the present study, LIV-first (16.3 mg/kg, p.o.) was used to screen the hepatoprotective activity. Hepatotoxicity was induced in experimental animals by administration of carbon tetrachloride (CCl4) (1 ml/kg, i.p). Silymarin (25 mg/kg,p.o.) was used as the standard. Biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and serum bilirubin were measured. Cytotoxicity of CCl4 was estimated by quantitating the release of malondialdehyde. The activity of tissue antioxidant enzymes namely superoxide dismutase, catalase and the level of total protein and glutathione were also measured. Histopathological evaluation of liver sections was also done. CCl4 administration in rats elevated the levels of SGPT, SGOT, ALP and bilirubin. Administration of LIV-first significantly ( P 0.01) prevented this increase. The activity of anti-oxidant enzymes in carbon tetrachloride CCl4 -treated group was decreased and these enzyme levels were significantly ( P<0.05) increased in LIV-first-treated groups. Histopathological studies revealed that the concurrent administration of CCl4 with the extract exhibited protection of the liver tissue, which further evidenced the above results. The study confirmed the hepatoprotective activity of LIV-first, which may be attributed to its antioxidant property. More »»

2010

Journal Article

Dr. S. Sathianarayanan, Jose, A., Rajan, A., Baby, D., John, V. K., and Madhu, M., “Phytochemical Investigations and Antibacterial Activity of Chloroform Extract of Leaves of Wrightia tinctoria. ”, Biomed, vol. 5, no. 1, pp. 26 - 30, 2010.

2009

Journal Article

S. M Sekhar, Dr. Aneesh T. P., Dr. S. Sathianarayanan, JinyVarghese, K., Vasudevan, D., and Revikumar, K., “Prophylaxis in migraine management”, Journal of Young Pharmacists, vol. 1, p. 86, 2009.[Abstract]


A migraine is the most common cause of severe, recurring headache. With the recent advances in our understanding of migraine, it can be effectively treated and even prevented. Prophylactic treatment of migraines is indicated when patients have three or more severe migraine attacks a month that interfere with quality of life or when attacks are prolonged and symptomatic medication used alone is not satisfactory. The major objective of migraine prophylactic therapy is optimizing the patientís ability to function normally by reducing the frequency, duration, and intensity of attacks. The major migraine preventive therapies include β-blockers, calcium-channel blockers, and tricyclic medications. Preventive treatment should be tailored to individual patient needs. This requires that patient and healthcare professionals understand the rationale and participate actively in decisions regarding therapeutic intervention. More »»

2009

Journal Article

Dr. S. Sathianarayanan, .Selvam, P., Jose, A., George, R. Mary, and .G.Ravikumar, K., “Preliminary phytochemical screening and study of antiviral activity and cytotoxicity of Wrightia tinctoria. ”, International Journal of Chemical Science, vol. 7, no. 1, pp. 1 - 5, 2009.

2009

Journal Article

Dr. S. Sathianarayanan, .Saravanakumar, A., Baby, L. Trisa, and Abraham, S., “Antimicrobial activity of various extracts of Justicia tranqurbariensis”, International Journal of Advanced Pharmacology and Toxicology, vol. 10, no. 2, pp. 81 - 84, 2009.

2009

Journal Article

Dr. S. Sathianarayanan, Jose, A., Abraham, S., and Thomas, D. Grace, “Diuretic activity of aqueous and alcoholic extracts of Justicia tranqurbariensis”, International Journal of Advanced Pharmacology and Biological Sciences, vol. 3, no. 3, pp. 119 - 121, 2009.

2009

Journal Article

Dr. S. Sathianarayanan, ,, .N.Fasmi, K., and , “Holistic way to green life”, The Internet Journal of Alternative Medicine, vol. 7, 2009.

2009

Journal Article

Dr. S. Sathianarayanan, ,, ,, and Abraham, S., “Quality Pharmaceutical Education in India-Need of the Hour”, The Indian Journal of Technical Education, vol. 32, no. 2, pp. 66 - 70, 2009.

2009

Journal Article

Dr. S. Sathianarayanan, ,, ,, and Abraham, S., “Effect of Ampicillin Soduium on Immune Response. ”, Journal of Pharmacy Research, vol. 2, no. 3, 2009.

2009

Journal Article

Dr. S. Sathianarayanan, ,, Abraham, S., and Varghese, A., “Absorption and Metabolism Of Xenobiotics: An Overview”, The Internet Journal of Nutrition and Wellness. , vol. 7, no. 1, 2009.

2009

Journal Article

Dr. S. Sathianarayanan, ,, Baby, J. C. T., ,, and , “A Modern Tool For Pharmacology.”, The Internet Journal of Medical Simulation, vol. 2, no. 2, 2009.

Publication Type: Book

Year of Publication Publication Type Title

2010

Book

J. Asha and Dr. S. Sathianarayanan, Pharmaceutical Analytical Chemistry (Theory & Practical). Delhi: Birla Publications Pvt, Ltd., 2010.[Abstract]


The book is concerned with Science and application of modern and traditional techniques for the analysis of Pharmaceutical products. More »»
207
PROGRAMS
OFFERED
5
AMRITA
CAMPUSES
15
CONSTITUENT
SCHOOLS
A
GRADE BY
NAAC, MHRD
8th
RANK(INDIA):
NIRF 2018
150+
INTERNATIONAL
PARTNERS