Dr. Sathianarayanan joined as lecturer in the Department of Pharmaceutical Chemistry at Amrita in February 2007. He completed his B. Pharm. and M. Pharm. from Dr. M G R Medical University, Chennai. He received his Ph. D. in Pharmacy from Karpagam University, Coimbatore.

Dr. Sathianarayanan's interests broadly include Semi-synthetic, Synthetic and Phytochemical Analysis. He has a strong academic background and extensive research experience with specialization in isolation and characterization of biologically active compounds. He has knowledge in docking studies, experimental pharmacology and handling of animals like rat, mice and rabbit to screen various pharmacological action.

Currently, he is involved in the Study of Isolation and Characterization of Bioactive Compounds from Herbs and Marine Organisms and Derivatization of Phytoconstituents, including the design, synthesis and development of bioactive heterocyclic compounds for the treatment of infectious diseases, cancer and immune related disorders. It is hoped that this novel approach will help a newer drug development with safety and efficacy.

He received a major funded project from Ministry of Earth Sciences of Rs 75.60 lakhs for the study titled High Through Put Screening of Biological Activity of Extracts from Deep Sea Marine Organisms. The Kerala State Council For Science, Technology and Environment has also funded for the Study - Synthesis of some Novel Scaffold for Anti-Prostate Cancer.

A text book titled Pharmaceutical Analytical Chemistry authored by Dr. Sathianarayanan was published by Birla Publications Pvt. Ltd, New Delhi. The book mainly focuses on the needs of undergraduate and postgraduate pharmacy students. It explains the science and application of modern and traditional techniques for the analysis of pharmaceutical products.

In his capacity as guide, he is mentoring B. Pharm. and M. Pharm. Thesis Projects some of which include:

  1. Phytochemical investigation and various pharmacological evaluation of Andrographis paniculata and Swertia chirayita.

  2. Phytochemical investigation and pharmacological screening of Ventilago madraspatana as an immunomodulator.

  3. Insilico design and synthesis of some novel Isatin and Quinazoline derivatives against mammary carcinoma.

  4. Design, synthesis and biological evaluation of anti-prostate cancer agents.

  5. Phytochemical and pharmacological screening of Wrightia tinctoria.

  6. Anthelmintic, antioxidant and immunomodulatory activity of methanolic extracts of Wrightia tinctoria leaves.

  7. Phytochemical screening and anticancer activity of Indigofera tinctoria.

  8. Synthesis, anticancer activity and QSAR analysis of substituted derivatives containing Indole moiety.

  9. In-vitro cytotoxic and antimicrobial activity of microwave assisted synthesized Isatin derivative.

  10. Insilico design and molecular docking studies of PDE-4 inhibitors for the treatment of psoriasis using some new Andrographolide, Isatin and Emodin derivatives.

  11. Priliminary phytochemical investigation and invitro anti-inflammatory activity of Sargassum wightii (Greville).

  12. Insilico design and synthesis of novel anti-inflammatory agents.

  13. Anti oxidant and cytotoxic activity of deep sea marine organism Hetractic magnifica.



Publication Type: Journal Article
Year of Publication Publication Type Title
2011 Journal Article E. Varghese, S. Narayanan, S., Gopal, R. V., Nair, A., Chittethu, A. B., and Anson, T. A., “Aticancer activity of chloroform extract of Helicteres ISORA”, International Journal of Pharmacy and Technology, vol. 3, pp. 2560-2564, 2011.[Abstract]

Helicteres isora belongs to the family sterculiaceae is an ayurvedic herb.it is distributed widely in forest throughout india and are commonly known as east india screw tree spi_sup1spii_sup. Is a medicinally important sub-deciduous shrub or small tree.almost all parts of the plant are used in traditional medicinal system for curing various diseases. its fruit,Root and bark possess significant antidiabetic. Antioxidant,Antimicrobial and hypolipidemic activity. the fruit of helicterusisora after collection,Authentication and drying was extracted with chloroform using soxhlet extractor.the present study was aimed to determine the preliminary phytochemical evaluation and cytotoxicity study of the chloroform extract of helicteres isora on MCF - 7 cell line (human breast cancer) by MTT assay method. the preliminary phytochemical evaluation showed the presence of carbohydrates,Flavonoids,Tannins and alkaloidsspi_sup2spii_sup.its cytotoxic evaluation showed a potent action against to MCF - 7 (michigan cancer foundation - 7) cell line. More »»
2010 Journal Article T. B. Lima, Suja, A., Jisa, O. J., S. Narayanan, S., and Remya, K. S., “Hepatoprotective activity of LIV-first against carbon tetra chloride-induced hepatotoxicity in albino rats”, International Journal of Green Pharmacy, vol. 4, pp. 71-74, 2010.[Abstract]

Liver toxicity is a major health problem of worldwide proportions. Herbal medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases. In the present study, LIV-first (16.3 mg/kg, p.o.) was used to screen the hepatoprotective activity. Hepatotoxicity was induced in experimental animals by administration of carbon tetrachloride (CCl4) (1 ml/kg, i.p). Silymarin (25 mg/kg,p.o.) was used as the standard. Biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and serum bilirubin were measured. Cytotoxicity of CCl4 was estimated by quantitating the release of malondialdehyde. The activity of tissue antioxidant enzymes namely superoxide dismutase, catalase and the level of total protein and glutathione were also measured. Histopathological evaluation of liver sections was also done. CCl4 administration in rats elevated the levels of SGPT, SGOT, ALP and bilirubin. Administration of LIV-first significantly ( P 0.01) prevented this increase. The activity of anti-oxidant enzymes in carbon tetrachloride CCl4 -treated group was decreased and these enzyme levels were significantly ( P<0.05) increased in LIV-first-treated groups. Histopathological studies revealed that the concurrent administration of CCl4 with the extract exhibited protection of the liver tissue, which further evidenced the above results. The study confirmed the hepatoprotective activity of LIV-first, which may be attributed to its antioxidant property. More »»
Publication Type: Book
Year of Publication Publication Type Title
2010 Book J. Asha and S. Narayanan, S., Pharmaceutical Analytical Chemistry (Theory & Practical). Delhi: Birla Publications Pvt, Ltd., 2010.[Abstract]

The book is concerned with Science and application of modern and traditional techniques for the analysis of Pharmaceutical products. More »»
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