Qualification: 
MD, MBBS
sadiakhan20004@aims.amrita.edu

Dr. Sadiya Khan currently serves as Associate Professor at the Department of Microbiology, School of Medicine, Kochi.

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2017

Journal Article

S. Khan and Kumar, A., “Hepatitis B Vaccination for Healthcare Workers”, Indian Journal of Medical Microbiology, vol. 35, p. 315, 2017.

2015

Journal Article

Dr. Anil Kumar V. and S. Khan, “Defining Multidrug Resistance in Gram-negative Bacilli”, Indian Journal of Medical Research, vol. 141, pp. 491-493, 2015.

2013

Journal Article

R. Girish, V. Kumar, A., S. Khan, Dinesh, K. R., and Karim, S., “Revised ciprofloxacin breakpoints for Salmonella: Is it time to write an obituary?”, Journal of Clinical and Diagnostic Research, vol. 7, pp. 2467-2469, 2013.[Abstract]


Objectives: To determine the minimum inhibitory concentration of ciprofloxacin among 50 blood stream isolates of Salmonella enterica. Material and Methods: A total of 50 consecutive isolates of Salmonella enterica were tested for susceptibility to antimicrobials using the Kirby Bauer disk diffusion method. Minimum inhibitory concentrations were determined using Hi-Comb strips. All results were interpreted according to the CLSI guidelines. Results: Of the 50 isolates 70%were Salmonella Typhi, 4% Salmonella paratyphi A, 2% Salmonella paratyphi B and the remaining 10% were identified only as Salmonella species. Using the CLSI 2011 breakpoints for disc diffusion, 86% (43/50) were resistant to nalidixic acid(NA), 22% (11/50) to ciprofloxacin, 12% to azithromycin, 6% to cotrimoxazole, 4% to ampicillin and 1% to chloramphenicol. The MIC50 and MIC90 of ciprofloxacin for S.Typhi were 0.181 μg/mL and 5.06 μg/mL respectively. While the same for S. paratyphi A was 0.212μg/mL and 0.228μg/mL respectively. None of the isolates were multi drug resistant and all were susceptible to ceftriaxone. Using the CLSI 2012 revised ciprofloxacin breakpoints for disc diffusion (>31mm) & MIC (<0.06 μg/mL), 90% (45/50) of these isolates were found to be resistant. Conclusion: MIC's of ciprofloxacin should be reported for all salmonella isolates and should be used to guide treatment. Blindly following western guidelines for a disease which is highly endemic in the subcontinent will spell the death knell of a cheap and effective drug in our armamentarium. Therefore it will be too premature to declare that "the concept of using ciprofloxacin in typhoid fever is dead!".

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2012

Journal Article

S. Khan and V. Kumar, A., “Pitfalls of interpreting ciprofloxacin minimum inhibitory concentrations in salmonella enterica serovar typhi”, Indian Journal of Medical Research, vol. 136, p. 884, 2012.

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