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Dr. Sahadev Shankarappa

Asst. Professor

Dr. Sahadev Shankarappa currently serves as an Assistant Professor at Amrita Center for Nanosciences and Molecular Medicine at Kochi campus of Amrita Vishwa Vidyapeetham. He is a recipient of the prestigious Ramalingaswami re-entry fellowship administered by the Department of Biotechnology, Government of India.

Qualification: Ph.D
@amrita.edu

Bio

Dr. Sahadev Shankarappa joined Amrita Centre for Nanosciences and Molecular Medicine as an assistant professor in May 2013 and currently heads the laboratory of neuronal drug delivery. He is a physician-scientist with post-doctoral training in the laboratories of Professors Robert Langer at MIT and Daniel Kohane at Boston Children’s Hospital, Harvard Medical School, Boston. He has a Ph.D. in Neurosciences from Loyola University Chicago, MPH from the University of North Carolina at Chapel Hill, and M.B.B.S. from Bangalore University. He is also the recipient of the prestigious Ramalingaswami re-entry fellowship, administered by the Department of Biotechnology, Government of India. His research interest is in the field of axonal biology and trying to devise strategies to utilize axons as a route for drug delivery for the nervous system to treat disorders such as chronic neuropathic pain. In addition, Dr. Sahadev is also currently working on examining plant-waste as a potential raw material for bio-medical applications. Apart from research, Sahadev is currently working on becoming a long distance runner.

 

Publications

Journal Article

Hydrogel Systems and Their Role in Neural Tissue Engineering

Authors : Dr. Sahadev Shankarappa, Madhusudanan, Pallavi, Raju, Gayathri

Publisher : Journal of The Royal Society Interface,

Research

Pain is a critical component of life that is necessary for survival. However, uncontrolled and unwarranted pain secondary to underlying disease conditions is responsible for significant morbidity among people worldwide. Treating such ‘pain conditions’ is extremely difficult; one of the primary challenges being, the inability in delivering drugs to specific neuronal target sites. To address this challenge, the laboratory of neuronal drug delivery focuses on developing novel and cost-affordable avenues to delivery therapeutic drugs to treat pain conditions.

 

Neurons & Nanoparticles

The emphasis of the lab is to use our understanding of pain neurobiology to design and develop rationale delivery platforms using nano/ micro technology that will better facilitate neural drug delivery with decreased systemic side effects. We have recently established an animal behavioural testing laboratory that is equipped with various pain monitoring equipment to facilitate recording and quantifying pain responses in animal models.

Key focus of the lab includes:

  • Investigating the potential use of metal and polymer-based nanoparticles, as drug delivery agents in pain disorders.
  • Understanding the cellular mechanisms of nano-particulate delivery-vehicle uptake and transport in sensory neurons involved in the pain pathway.
  • Developing innovative approaches to attenuate pain in patients suffering from cancer induced bone-pain.
  • Studying the role of peripheral glial cell response in the pain pathway and effect of nanoparticles on such cellular responses.
  • Bio-medical applications and uses of non-edible plant-derived wastes.

 

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