Qualification: 
M. Pharm.
saritha19489@aims.amrita.edu

Mrs. Saritha A Surendran joined Amrita in July 2013. She completed her Master's Degree in Pharmaceutics from College of Pharmaceutical Sciences, Govt. Medical College Calicut, Calicut University and Bachelor's Degree in Pharmacy from St. James College of pharmaceutical sciences, Chalakudy, Calicut University. She has more than 5 years of teaching experience and 1.3 years of industrial experience. She currently has 10 international and national publications. She is presently supervising B.Pharm students in their research project on novel drug delivery.

Publications

Publication Type: Journal Article

Year of Publication Publication Type Title

2018

Journal Article

J. Mariam Joshua, Anilkumar, A., CU, V., vasudevan, D. T., and Saritha Surendran, “Formulation and evaluation of antiaging phytosomal gel”, Asian J Pharm Clin Res, vol. 11, pp. 1-15, 2018.

2017

Journal Article

J. JM, R, H., FK, J., and Saritha Surendran, “Formulation of propranolol hydrochoride oral thin fims for migraine prophylaxis”, Int. J. Pharm. Sci. , vol. 42, no. 1, pp. 8-14 , 2017.[Abstract]


The aim of present work deals with formulation of Propranolol hydrochloride oral thin films for migraine prophylaxis. Propranolol
hydrochloride is a non-selective beta-adrenergic antagonist and completely absorbed from the gastrointestinal tract. On the other
hand, nearly 75% of drug undergoes pre-systemic metabolism by the liver, thus bioavailability is reduced to 25%. The purpose of
developing this dosage form is to reduce the dose by bypassing its first pass metabolism. Films were prepared from F1-F6 by solvent
casting technique. Pullulan was selected as polymer because of its good water solubility and propylene glycol as plasticizer.
Polyvinyl pyrollidone was selected as disintegrate, citric acid as saliva stimulating agent, mannitol as sweetening agent and menthol
was used as flavoring agent. The compatibility of the drug in the formulation was confirmed by FT-IR and DSC. Formulated films
were subjected to various evaluation parameters. Based on the evaluation parameters, F4 has disintegration time of 47 sec and
showed promising drug release of 93% after 20 min. Scanning Electron Microscopy (SEM) of F4 showed smooth surface and little
pores. The stability study proved that the formulation F4 was found to be stable in both refrigerator and room temperature. Ex vivo
permeation study of F4 showed 91% of drug permeation through goat oral mucosa: hence formulation F4 was selected as best
formulation.

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2016

Journal Article

A. J. Nair, Soman, P., George, A., and Saritha Surendran, “Formulation of Myristica fragrans (Nutmeg) topical gel and its in vitro evaluation for antinflammatory activity”, International Journal of Pharmacy and Technology, vol. 8, pp. 11065-11076, 2016.[Abstract]


The purpose of this research was to formulate and evaluate an anti-inflammatory gel using ethanolic extract obtained from seeds and arillus of Myristica fragrans. In the present work, ethanolic extract of Myristica fragrans was prepared by maceration technique. The gels were formulated using different concentrations of carbopol 934, ethanolic extract of Myristica fragrans and piperine as permeability enhancer. The formulated gel was characterized using parameters like clarity, homogeneity, stability, extrudability, washability and in-vitro anti-inflammatory activity. The in-vitro anti-inflammatory property of the gel was determined using protein denaturation technique and was compared to marketed diclofenac gel. The results obtained indicate a concentration dependent increase in percentage inhibition of albumin denaturation by both the formulated gels (66 ± 0.3%) and marketed gels (63.7 ± 0.2%).From the present findings, it was concluded that the topical anti-inflammatory gel prepared from the extract of seeds and mace of Myristica fragrans have greater in-vitro anti-inflammatory property compared to the marketed gel formulation. © 2016, International Journal of Pharmacy and Technology. All rights reserved. More »»

2016

Journal Article

J. M. Joshua, Hari, R., Jyothish, F. K., and Saritha Surendran, “Fast dissolving oral thin films: An effective dosage form for quick releases”, International Journal of Pharmaceutical Sciences Review and Research, vol. 38, pp. 282-289, 2016.[Abstract]


Oral route is one of the most preferred routes of drug administration because of low-cost and ease of administration increases the patient compliance. Many patients especially geriatric and paediatric have difficulty to swallow the tablets and hard gelatine capsules. Fast dissolving drug delivery systems (FDDDS) were developed as an alternative to tablet, capsule and syrups. Among this, fast dissolving oral thin-films are useful in patients such as paediatric, bedridden or developmentally disabled, geriatric, who face difficulty in swallowing tablets or hard gelatine capsules. Oral fast dissolving film is relatively a new dosage form in which thin film is prepared using hydrophilic polymers, which rapidly disintegrate or dissolves on tongue or in the buccal cavity. It is an alternative platform for molecules that undergoes high first pass metabolism. The present review gives an account of different formulations, methods of preparation and quality control of the fast dissolving oral thin films. © 2016, Global Research Online. All Rights Reserved. More »»

2016

Journal Article

Saritha Surendran, M, J. J., R, H., and K, J. F., “Formulation of propranolol hydrochloride oral thin films for migraine prophylaxis”, International Journal of Pharmaceutical Sciences Review and Research, vol. 42, pp. 8 - 14, 2016.[Abstract]


The aim of present work deals with formulation of Propranolol hydrochloride oral thin films for migraine prophylaxis. Propranolol hydrochloride is a non-selective beta-adrenergic antagonist and completely absorbed from the gastrointestinal tract. On the other hand, nearly 75% of drug undergoes pre-systemic metabolism by the liver, thus bioavailability is reduced to 25%. The purpose of developing this dosage form is to reduce the dose by bypassing its first pass metabolism. Films were prepared from F1-F6 by solvent casting technique. Pullulan was selected as polymer because of its good water solubility and propylene glycol as plasticizer. Polyvinyl pyrollidone was selected as disintegrate, citric acid as saliva stimulating agent, mannitol as sweetening agent and menthol was used as flavoring agent. The compatibility of the drug in the formulation was confirmed by FT-IR and DSC. Formulated films were subjected to various evaluation parameters. Based on the evaluation parameters, F4 has disintegration time of 47 sec and showed promising drug release of 93% after 20 min. Scanning Electron Microscopy (SEM) of F4 showed smooth surface and little pores. The stability study proved that the formulation F4 was found to be stable in both refrigerator and room temperature. Ex vivo permeation study of F4 showed 91% of drug permeation through goat oral mucosa: hence formulation F4 was selected as best formulation.

More »»

2015

Journal Article

S. Viswam, Chithra, J., and Saritha Surendran, “Gene therapy in paediatrics - A review”, International Journal of Pharmaceutical Sciences Review and Research, vol. 31, pp. 14-17, 2015.[Abstract]


Genes are the basic physical and functional units of hereditary and are the specific sequences of bases that are carried on chromosomes which encode instruction, ensure the formation of proteins. Deficiency or disorders of genes in cells leads to the genetic disorders resolved with the respected treatment of gene therapies. The different types of viruses used as gene therapy are retroviruses, adenoviruses, adeno-associated viruses, herpes simplex viruses. Gene therapy is a type delivery where therapy carries the promise of cures for many diseases and for types of medical treatment most of us would not have thought possible. With gene therapy, the treatment or elimination of inherited diseases or physical conditions due to these mutations could become a reality. Gene therapy methods have continued to develop rapidly, and many initial limitations that hampered clinical application have been overcome. Thus serious consideration of clinical application of gene therapy is warranted for selected disorders in which the pathogenesis is well defined. Gene therapy is used to pediatrics for treating leukaemia, diabetics, arthritis, cystic fibrosis etc. More »»

2015

Journal Article

Saritha Surendran and Iyer, S. R., “Fast dissolving tablet using solid dispersion technique: An overview”, Indo American Journal of Pharmaceutical Research, 2015 ISSN NO: 2231-6876, vol. 5, pp. 668-679, 2015.[Abstract]


Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bio availability of a range of poorly water-soluble drugs. The focus of one part of the review article is based on solid dispersion mainly advantages, disadvantages, types, the method of preparation, and characterization of the solid dispersion at laboratory and industrial level. Solid dispersion is basically a drug–polymer two-component system; the drug–polymer interaction is the determining factor in its design and performance. It also discusses about modern characterization technique to characterize solid dispersion. In this review, it is intended to discuss the recent advances related on the area of solid dispersion technology. Different methods are also been used for preparation of solid dispersions such as Melting method, Solvent method, Melting solvent method ,Melt extrusion method, Lyophilisation Technique, Melt Agglomeration Process, The Use Of Surfactant, Electro spinning and Super Critical Fluid (Scf) Technology. The introduction of fast dissolving dosage forms has solved some of the problems encountered in administration of drugs to the pediatric and elderly patient, which constitutes a large proportion of the world's population. Fast dissolving tablet containing solid dispersion was developed to improve the dissolution of drug and stability of solid dispersion. They are disintegrating and/or dissolve rapidly in the saliva without the need for water. Thus it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. The later part of the article focus on the progress in methods of manufacturing, evaluation and various latest technologies involved in the development of Fast dissolving tablets.

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2015

Journal Article

M. Sasidharan, M, R., T.S, S., and Saritha Surendran, “Stem Cell Transplantation: Umbilical Cord”, International Journal of Pharma Research & Review (IJPRR), vol. 4, no. 3, pp. 15-21, 2015.[Abstract]


Umbilical cord blood transplant is desirable and alternative therapeutic treatment with long term benefits. Umbilical cord blood transplantation has been increasingly used over the past years for both malignant and non-malignant hematologic and other diseases as an alternative to mismatched-related or matched-unrelated bone marrow or peripheral blood hematopoietic stem cell transplantation. It has unique advantages of easy procurement, absence of risk to donors, low risk of transmitting infections, immediate availability, greater tolerance of human leukocyte antigen (HLA) disparity, and lower incidence of inducing severe graft-versus-host disease (GVHD). The first transplantation was performed in 1988, it is estimated that approximately 4,000 patients, with malignant and non-malignant diseases, were transplanted withcord blood transplantation. Comparing to bone marrow transplants, cord blood's collection is easier and safer. Umbilical cord blood is an alternative hematopoietic stem cell source that can cause various diseases through transplantation. The expansion of umbilical cord blood has led to the establishment of UCB quality standard by professional groups such as AABB (American Academy Of Blood Bank) & the foundation for accreditation of cellular therapy. One of the disadvantage of cord blood is its low cell content which limits cord blood transplantation to generally low weight recipients, such as children. Various alternatives have been used to overcome this limitation, including co-infusion of two partially HLA-matched cord blood units

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2015

Journal Article

S. Thampi B. S, J, C., and Saritha Surendran, “Myotonic Dystrophy and the Heart – A Review”, International Journal of Pharma Research & Review, vol. 4, no. 2, pp. 34-41, 2015.[Abstract]


Myotonic Dystrophy (Dystrophia Myotonica, DM) is the most frequently inherited neuromuscular disease of adult life. DM is a multisystem disease with major cardiac involvement. Core features of myotonic dystrophy are myotonia, muscle weakness, cataract, and cardiac conduction abnormalities. Classical DM (first described by Steinert and called Steinert’s disease or DM1) has been identified as an autosomal dominant disorder associated with the presence of an abnormal expansion of a CTG tri nucleotide repeat on chromosome 19q13.3 (the DM 1 locus). DM1 is inherited in an autosomal dominant pattern. And the underlying mutation is an unstable expansion of CTG repeats in the 3′ untranslated region (3′UTR) of the dystrophia myotonica protein kinase gene (DMPK, MIM* 605377) and in the promoter of the downstream SIX homeobox 5 gene (SIX5, MIM* 600963).Based on the nature of the causing mutation, DM1 belongs to “disorders of unstable repeat expansion”. Being the first disease described with an RNA gain-of-function mutation effect, DM1 is now the paradigm for RNA toxicity model of the disease pathogenesis, as reviewed elsewhere. A similar but less common disorder was later described as proximal myotonic myopathy, caused by alterations on a different gene on chromosome 3q21 (the DM2 locus). This article will mainly focus on DM1. It will provide an insight into the epidemiology and genetic alterations of the disease and provide up-to-date information on postmortem and clinical findings and on diagnostic and therapeutic options in patients presenting cardiac involvement.

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2014

Journal Article

Saritha Surendran and O.G, V., “Formulation, evaluation and optimization of Clotrimazole solid Dispersion incorporated Gels.”, journal of medical pharmaceutical and allied sciences, 2014.[Abstract]


The Goal of the present investigation was to design and evaluate gels for topical delivery of water insoluble antifungal agent, Clotrimazole with an aim to increase its penetration through skin. Clotrimazole is a broad spectrum imidazole derivative useful in the treatment of superficial fungal infections. Purpose was to improve the solubility, invitro characteristics and dissolution properties of Clotrimazole by the preparation of its solid dispersion with beta cyclodextrin using kneading method by using different drug carrier ratios. Prepared solid dispersion was evaluated for percent practical yield, drug content uniformity, in vitro dissolution rate, DSC and IR studies. Solid dispersions was optimized based on the release characteristics, and were incorporated into gels. Faster dissolution was exhibited by solid dispersion containing l: l ratio of drug: β-cyclodextrin by kneading method. Gels have gained more importance because the gel-bases formulations are better percutaneously absorbed than creams and ointment bases. The gels were formulated by using Carbopol 940, HPMC, and Methyl cellulose and evaluated for pH, drug content, spreadability, extrudability, viscosity determination and diffusion study. Invitro drug release of clotrimazole solid dispersion incorporated gels was showed that Carbopol gels was showed higher drug release as compared to HPMC, methyl cellulose gels. Optimized gel was then undergone skin irritation test, stability studies, and invitro antifungal test. In conclusion, the optimized gel showed good physicochemical properties, better drug release, and reasonable stability

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2013

Journal Article

Saritha Surendran, “Formulation And Evaluation Of Clotrimazole Solid Dispersion Incorporated Gels”, International Journal of PharmTech Research, vol. 3, pp. 1345-1354, 2013.[Abstract]


The goal of the present investigation was to design and evaluate gels for topical delivery of water insoluble antifungal agent, Clotrimazole with an aim to increase its penetration through skin. Clotrimazole is a broad spectrum imidazole derivative useful in the treatment of superficial fungal infections. Purpose was to improve the solubility, invitro characteristics and dissolution properties of Clotrimazole by the preparation of its solid dispersion with beta cyclodextrin using kneading method by using different drug carrier ratios. Prepared solid dispersion was evaluated for percent practical yield, drug content uniformity, in vitro dissolution rate, DSC and IR studies. Solid dispersions was optimized based on the release characteristics, and were incorporated into gels. Faster dissolution was exhibited by solid dispersion containing l: l ratio of drug: β-cyclodextrin by kneading method. Gels have gained more importance because the gel-bases formulations are better percutaneously absorbed than creams and ointment bases. The gels were formulated by using Carbopol 940, HPMC, and Methyl cellulose and evaluated for pH, drug content, spreadability, extrudability, viscosity determination and diffusion study. Invitro drug release of clotrimazole solid dispersion with Carbopol gels showed higher drug release when compared to HPMC, methyl cellulose gels. In conclusion, the optimized gel showed good physicochemical properties, better drug release, and reasonable stability More »»
Faculty Research Interest: 
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