March 1, 2011
School of Pharmacy, Kochi
Ms. Anjali Nair G., third-year student of B.Pharm. at the Amrita School of Pharmacy won the best poster award at the recently concluded National Seminar on Herbal Indigenous Medicine for Better Living.
Organized by St. James College of Pharmaceutical Sciences, the seminar explored the Indian plant sources that could be used for medicinal preparations.
Ms. Anjali won the award for her poster titled Synthesis and preliminary antibacterial screening of some selected 6-methyl-2-oxo-4-phenyl-1,2,3,4, tetrahydropyrimidine-5-carbohydrazide derivatives.
Pyrimidines are well-known for their anti-cancer, anti-microbial, anti-fungal and anti-viral activities.
The award-winning poster illustrated the process of synthesis and antibacterial screening of different pyrimidine analogues.
The poster featured the following extracts of the work performed.
For the synthesis of the pyrimidine analogues, the reagents used were urea, ethylacetoacetate, and benzaldehyde. The first step involved the synthesis of the first compound, ethyl-6-methyl-2-oxo-4-phenyl-1,2,3,4 tetrahydropyrimidine-5-carboxylate from the above mentioned reagents.
Subsequent steps involved the condensation of the first compound with hydrazine hydrate to produce the second compound, 6-methyl-2-oxo-4-phenyl-1,2,3,4, tetrahydropyrimidine-5-carbohydrazide.
Three pyrimidine derivatives were prepared using the second compound, 6-methyl-2-oxo-4-phenyl-1,2,3,4, tetrahydropyrimidine-5-carbohydrazide.
Of these, the first pyrimidine analogue was prepared by condensing 6-methyl-2-oxo-4-phenyl-1,2,3,4, tetrahydropyrimidine-5-carbohydrazide with benzoyl chloride resulting in the formation of N phenyl carbonyl tetrahydropyrimidine carbohydrazide derivatives.
The second and third analogues were prepared by condensation of different aromatic aldehydes with 6-methyl-2-oxo-4-phenyl-1,2,3,4, tetrahydropyrimidine-5-carbohydrazide.
These analogues were then analyzed for their purity and antibacterial activities. The three newly synthesized compounds were screened for both gram positive and gram negative organism by agar diffusion method.