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“Recent studies have shown that there is a risk of developing Parkinson’s disease in patients with a group of disorders called Lysosomal Storage Disorder (LSD) especially Gauchers Disease, which is caused by bi-allelic mutations in GBA1, the gene that encodes acid beta-glucocerebrosidase. The enzyme glucocerebrosidase leads to the break up of fat and in the absence of this enzyme in childhood fat (lipids) accumulate in the brain. In a subset of patients affected with Gauchers later they develop symptoms of Parkinsons disease,” says Dr R. Sureshkumar, Professor, Department of Neurology, Amrita Institute of Medical Sciences, Kochi.

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