Metal complexes of Co(II), Ni(II), Cu(II), and Zn(II) with ligands (L1H and L2) derived from 4-aminoantipyrine, 2-hydroxy-3-formylquinoline, and isatin were synthesized and characterized by the elemental analysis, conductance measurements, magnetic susceptibility, and spectral analysis. The spectral data revealed that the ligands acted as a neutral tridentate, coordinating to the metal ion through the azomethine nitrogen, phenolic oxygen, and carbonyl oxygen of the 4-aminoantipyrine, 2-hydroxy-3-formylquinoline, and isatin molecule in ligands L1H and L2 only. Both the ligands and their metal complexes were studied for cyclic voltammetry studies. The ligand and the metal complexes were screened for their anticonvulsant activity, and it has been observed that the metal complexes are more potent than the ligands.
G. S. Kurdekar, Sathisha, M. P., Budagumpi, S., Dr. Naveen V. Kulkarni, Revankar, V. K., and Suresh, D. K., “4-Aminoantipyrine-based Schiff-base transition metal complexes as potent anticonvulsant agents”, Medicinal Chemistry Research, vol. 21, pp. 2273–2279, 2012.