Publication Type:

Journal Article

Source:

International Journal of Biological Macromolecules, Volume 63, p.154-157 (2014)

URL:

https://www.scopus.com/inward/record.url?eid=2-s2.0-84888339092&partnerID=40&md5=012b25d9a2a47cbd76eadef4a8dd270d

Keywords:

Amidase encapsulation; Immunogenicity; Staphylococcus aureus

Abstract:

This work reports the development of amidase encapsulated&nbsp;<em>O</em>-carboxymethyl chitosan nanoparticles (Ami-<em>O</em>-CMC NPs) of 300&nbsp;±&nbsp;50&nbsp;nm size by ionic cross-linking method. The prepared Ami-<em>O</em>-CMC NPs had an encapsulation efficiency of 55.39%. Haemolysis assay and cytotoxicity studies proved the hemocompatibility and cytocompatibility of the prepared NPs. The sustained release of Ami from the NPs is expected to prolong its immunogenicity and in turn lead to development of better protective immunity against&nbsp;<em>Staphylococcus aureus</em>&nbsp;infections.

Notes:

cited By 3

Cite this Research Publication

K. T. Smitha, Sreelakshmi, M., Nisha, N., Jayakumar, R., and Dr. Raja Biswas, “Amidase encapsulated O-carboxymethyl chitosan nanoparticles for vaccine delivery”, International Journal of Biological Macromolecules, vol. 63, pp. 154-157, 2014.

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