Background and Objectives: Of late people in many parts of the world have started preferably to consume drugs from the traditional system particularly to rheumatoid authorities. Due to change of life style of the people even at the middle age level arthritic problems appear often. But the herbal drugs under the traditional system have not been properly validated scientifically therefore it is proposed to have Enicostemma littorale (Blume) used in the folk medicine for rheumatic pain was selected for scientific validation. Methods: The 85 % methanolic extract obtained from the whole plant of Enicostemma littorale had been assessed for analgesic and anti-inflammatory activity. The analgesic activity by hot plate and tail immersion methods and the anti-inflammatory, and antioxidant activities had been evaluated by Complete Freund's adjuvant induced arthritic model. Results: The results of the evaluation on analgesic activity in hot plate and tail immersion methods revealed the extracts exhibition of a significant activity at 150 mg/kg b.wt. itself and the effect was found to be increased dose dependently. In Freund's adjuvant induced arthritis, Enicostemma littorale was noticed to decrease the paw volume by 15.81 %. Significant protection was also observed by elevating antioxidant enzymes. Conclusion: In conclusion, the 85 % methanolic extract of Enicostemma littorale possesses significant analgesic and anti-inflammatory activities according to Freund's adjuvant induced arthritic model in rats. Based on this study, Enicostemma littorale can be considered to be a potentially useful drug suitable to control the rheumatoid arthritis.
M. M. Shabi, Uthirapathy, S., Raj, D., Krishnamoorthy, G., Ravindhran, D., Jipnomon Joseph, and Rajamanickam, G. V., “Analgesic and Anti-Arthritic Effect of Enicostemma littorale Blume”, Advances in Bioscience and Biotechnology, vol. 05, pp. 1018-1024, 2014.