The curcumin-encapsulated chitosan-graft-poly(N-vinyl caprolactam) nanoparticles containing gold nanoparticles (Au-CRC-TRC-NPs) were developed by ionic cross-linking method. After “optimum RF exposure” at 40W for 5min, Au-CRC-TRC-NPs dissipated heat energy in the range of ∼42°C, the lower critical solution temperature (LCST) of chitosan-graft-poly(N-vinyl caprolactam), causing controlled curcumin release and apoptosis to cancer cells. Further, in vivo PK/PD studies on swiss albino mice revealed that Au-CRC-TRC-NPs could be sustained in circulation for a week with no harm to internal organs. The colon tumor localization studies revealed that Au-CRC-TRC-NPs were retained in tumor for a week. These results throw light on their feasibility as multi-responsive nanomedicine for RF-assisted cancer treatment modalities
S. N. Rejinold, Thomas, R. George, Muthiah, M., Chennazhi, K. P., Manzoor, K., Park, I. - K., Jeong, Y. Yeon, and Dr. Jayakumar Rangasamy, “Anti-cancer, Pharmacokinetics and Tumor Localization Studies of pH-, RF- and Thermo-Responsive Nanoparticles”, International Journal of Biological Macromolecules, vol. 74, pp. 249 - 262, 2015.