Publication Type:

Journal Article

Source:

Journal of experimental pathology, Volume 6, Number 1-2, p.95-105 (1992)

URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0026467656&partnerID=40&md5=258d749c5c76caebc404724c3e913a4f

Keywords:

Acute, acute lymphocytic leukemia, Antibodies, article, enzyme immunoassay, fluorescent antibody technique, Herpesvirus 6, Hodgkin disease, human, human herpesvirus 6, Immunoenzyme Techniques, immunology, India, Leukemia, Lymphocytic, lymphoma, Mouth Neoplasms, mouth tumor, Non-Hodgkin, nonhodgkin lymphoma, Viral, virus antibody

Abstract:

The prevalence and titre of IgG antibodies to human herpesvirus type 6 (HHV-6) were assayed in the serum samples from normal subjects and patients with Hodgkin's lymphoma (HL), non-Hodgkin's lymphoma (NHL), acute lymphoblastic leukaemia (ALL) and oral cancer (OC) using immunofluorescence and immunoperoxidase techniques. This forms the first study on the sero-prevalence and titre of antibodies to HHV-6 in India. There was no considerable difference in the prevalence (76%) and titre (10-160) of the antibodies in normal population from those reported for normal adults in other parts of the world. All the HL and ALL patients studied showed no significant elevation in the antibody titre, though a slight increase in the prevalence (95%) was noted. Antibody titre and prevalence were found highly elevated in OC. OC remained totally unstudied for the presence of anti-HHV-6 antibodies, and this is the first report of elevated levels of the antibody in this cancer. The role of HHV-6, if any, in the pathogenesis of OC is worth investigating.

Notes:

cited By 9

Cite this Research Publication

M. Yadav, Shanavas, K. R., Kala, V., Dr. Damodaran Vasudevan, and Vijayakumar, T., “Anti-HHV-6 antibodies in normal population and in cancer patients in India.”, Journal of experimental pathology, vol. 6, pp. 95-105, 1992.

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