Objective: The purpose of the present study was to reveal the potential pleotropic anti-inflammatory activity of two hmg-co Reductase inhibitors, Rosuvastatin and atorvastatin in comparison with standard drug diclofenac.
Methods: The method used for screening anti-inflammatry activity was In vitro human red blood cell membrane stabilization method.
Results: The results of our study revealed that atorvastatin and rosuvastatin showed effective in vitro(500mcg/ml) anti-inflammatory activity when compared with the standard drug diclofenac.
Conclusion: The rosuvastatin was more potent anti-inflamatory drug when compared with atorvastatin.
Keywords: Atorvastatin, Rosuvastatin, Membrane stabilizing, Anti-inflammatory
Rajitha Panonnummal and Varkey, J., “Anti-inflammatory activity of hmg Co A reductase inhibitors: A comparative study. ”, International Journal of Pharmacy & Pharmaceutical Sciences, vol. 7, no. 3, 2015.