Anti-inflammatory evaluation of the cinnamomum malabatrum (burm. f).blume leaves using carrageenan induced rat paw oedema method
Publication Type:Journal Article
Source:Research Journal of Pharmacy and Technology, Volume 6, Number 7, p.746-748 (2013)
Keywords:alcohol, alkaloid derivative, animal experiment, animal model, antiinflammatory activity, article, carbohydrate derivative, carrageenan, Cinnamomum, Cinnamomum malabatrum, Cinnamomum malabatrum extract, drug screening, drug synthesis, flavanoid, glycoside, indometacin, male, mercury, nonhuman, paw edema, phenol derivative, phytochemistry, plant extract, plant leaf, plethysmography, protein derivative, rat, saponin derivative, solvent extraction, tannin derivative, terpene derivative, terpenoid derivative, unclassified drug
Cinnamomum malabatrum is a small, tropical tree which grows up to 15 metres height, which belongs to the family Lauraceae. The fresh leaves of the plant were collected; it was extracted by successive solvent extraction. A preliminary phytochemical screening of the extracts were carried out. The leaves and bark of the young tree shows rich presence of various the phytoconstituents like Phenolics, Flavonoids, lignins, Terpenes and terpenoids, Plant acids, phytosterols etc. Therefore the objective of this study was to investigate the anti-inflammatory potential in the alcoholic extract of Cinnamomum malabatrum, by comparing with the standard drug Indomethacin. The method used for this study was Carrageenan induced rat paw oedema model, using a Plethysmometer. and male Wistar albino rats was used for carrying this work. The paw volume was measured at 1,2,3,4 hours after 1 hour of Carragenan(a well known Phlogistic agent) administration by mercury displacement method using plethysmograph. The change in the paw volume was observed and it is recorded, and the percentage of inhibition was calculated by using a specified formula. The alcoholic extract showed significant anti-inflammatory activity. The Ethanolic extract at a dose of 250mg/kg exhibit maximum anti-significant dose depended antiinflammatory activity. The pharmacological observations of the study concluded that the leaves of Cinnamomum malabatrum can be used for acute inflammation. © RJPT All right reserved.
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