Publication Type:

Journal Article

Source:

Materials Science and Engineering C, Elsevier Ltd, Volume 75, p.115-124 (2017)

URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013035891&doi=10.1016%2fj.msec.2017.02.037&partnerID=40&md5=6673d2834749669d2d42abe68503e86c

Keywords:

Anti-bacterial activity, Antibacterial, Bacteria, Cell culture, Escherichia coli, Hydrothermal processing, Metal ions, Metal Nanoparticles, Nanomodification, Nanoparticles, Osseointegration, Osteogenic differentiation, Scanning electron micrographs, scanning electron microscopy, Silver, silver nanoparticles, Stem cells, Substrates

Abstract:

<p>Nanosurface modification of Titanium (Ti) implants and prosthesis is proved to enhance osseointegration at the tissue–implant interface. However, many of these products lack adequate antibacterial capability, which leads to implant loosening. As a curative strategy, in this study, nanotextured Ti substrates embedded with silver nanoparticles were developed through a single step hydrothermal processing in an alkaline medium containing silver nitrate at different concentrations (15, 30 and 75 μM). Scanning electron micrographs revealed a non-periodically oriented nanoleafy structure on Ti (TNL) decorated with Ag nanoparticles (nanoAg), which was verified by XPS, XRD and EDS analysis. This TNLAg substrate proved to be mechanically stable upon nanoindentation and nanoscratch tests. Silver ions at detectable levels were released for a period of 28 days only from substrates incorporating higher nanoAg content. The samples demonstrated antibacterial activity towards both Escherichia coli and Staphylococcus aureus, with a more favorable response to the former. Simultaneously, Ti substrates incorporating nanoAg at all concentrations supported the viability, proliferation and osteogenic differentiation of mesenchymal stem cells. Overall, nanoAg incorporation into surface modified Ti via a simple one-step thermochemical method is a favorable strategy for producing implants with dual characteristics of antibacterial activity and cell compatibility. © 2017 Elsevier B.V.</p>

Notes:

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Cite this Research Publication

A. Mohandas, Krishnan, A. G., Dr. Raja Biswas, Dr. Deepthy Menon, and Dr. Manitha B. Nair, “Antibacterial and cytocompatible nanotextured Ti surface incorporating silver via single step hydrothermal processing”, Materials Science and Engineering C, vol. 75, pp. 115-124, 2017.

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