Publication Type:

Journal Article

Source:

J Hosp Infect, Volume 102, Issue 1, p.120-124 (2019)

Abstract:

<p>Outbreaks due to multidrug-resistant Candida auris have emerged as a large threat to modern medicine. Since skin colonization and environmental contamination have been identified as a precursor for outbreaks, we evaluated the antifungal activity of ultraviolet-C light using mercury vapour lamp with a peak emission of 254 ± 2 nm and octenidine dihydrochloride against C. auris clinical isolates. Octenidine dihydrochloride was found effective at significantly lower concentrations (0.00005-0.0004%) than those currently used in the clinical setting (0.05-0.1%). Scanning electron microscopy images show destruction of the organism within 6 h of exposure to 0.0005% octenidine dihydrochloride. Ultraviolet-C light could kill all C. auris with 15 min exposure.</p>

Cite this Research Publication

P. Ponnachan, Vinod, V., Pullanhi, U., Varma, P., Singh, S., Biswas, R., and Kumar, A., “Antifungal activity of octenidine dihydrochloride and ultraviolet-C light against multidrug-resistant Candida auris.”, J Hosp Infect, vol. 102, no. 1, pp. 120-124, 2019.