Purpose:The purpose of the study was to evaluate the dose dependent effects of atorvastatin against vancomycin induced renal damage. Methods:Nephrotoxicity was induced by vancomycin administration at a dose of 200mg/kg twice daily for 7 days. Nephrotoxicity was determined by carrying out renal function tests and is confirmed by renal histopathology. Measurements of antioxidant enzymes were also carried out to determine vancomycin induced alterations in cellular antioxidant status. Atorvastatin at three doses 5mg/kg,10mg/kg and 20mg/kg was tested for protective effect against renal damage induced by vancomycin due to its antioxidant mechanisms. Results:Higher doses of atorvastatin exhibits considerable degree of antioxidant activity and atorvastatin at 10mg/kg provided significant degree of protection. But low dose of atorvastatin was insufficient to provide a protective effect due to inability to restore the altered antioxidant status. Conclusions:Atorvastatin at 10mg/kg exhibit significant antioxidant activity and provide optimum level of protection against Vancomycin induced renal damage. But at 5mg/kg it does not show significant antioxidant effect sufficient to provide a protective effect. Atorvastatin at 20mg/kg showed effective antioxidant action but it failed to provide a protective effect in renal damage,may be due to its direct toxic effect on rat kidney.
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Rajitha Panonnummal, Varkey, Jb, and Dinoop, D. Rc, “Are statins nephroprotective?:A dose dependent study in albino rats”, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 5, pp. 182-190, 2013.