Acute liver failure (ALF) is a clinical entity associated with a high mortality rate, and the majority of these patients may require liver transplantation. N-Acetylcysteine (NAC), an antioxidant agent that replenishes mitochondrial and cytosolic glutathione stores, is an antidote for acetaminophen poisoning. However, their role in non-acetaminophen-related ALF is still not proven. Here, we discuss a 67-year-old male patient diagnosed with hepatitis with an acute liver injury who was admitted to Emergency Medicine. He was treated with NAC infusion for an average of 48 hrs, and later, it was found that his liver function tests improved. In this study, we could find that NAC plays a major role in improving the liver function test of patients with non-acetaminophen-related ALF.
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A. Thampi, Joy, J., Kumar, G., Sreekrishnan, T. P., and Ajith, V., “Asian journal of pharmaceutical and clinical research: A case report on role of N-acetylcysteine in non-acetaminophen-related acute liver injury”, Asian Journal of Pharmaceutical and Clinical Research, vol. 9, pp. 7-8, 2016.