Natural Killer activity assessed by 51Cr release assay from K-562 cells showed detectable activity from 5th day after tumour transplantation, reaching a peak on 12th day and thereafter showing a gradual decline in the activity. Antibody dependent cell mediated cytotoxicity estimated by 51Cr labelled sheep red blood cells anti SRBC system demonstrated a peak activity on 5th day. Cytotoxic T lymphocyte activity detected by 51Cr release of Dalton's lymphoma ascites target cells showed a peak on 10th day. Antibody complement mediated cytotoxicity revealed a similar pattern as natural killer cell activity.
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K. Suresh, Dr. Damodaran Vasudevan, Kuruvilla, K., and Nirmala, K., “Assessment of immunological parameters during tumour development in a murine model.”, Indian Journal of Experimental Biology, vol. 27, pp. 497-501, 1989.