Publication Type:

Journal Article


Applied Physics Letters, Volume 95, Number 22 (2009)



Atomic Force, Atomic force microscopes, atomic force microscopy, Cancer diagnostics, cancer research, Cell culture, Cell lines, Folate receptor, Functionalized, Ligands, Live cell, Microscopic study, Phase contrasts, Phase-contrast image, Receptor sites


Membrane associated folate receptors (FR) is gaining importance in cancer research. Understanding the FR density, distribution, and the strength of its interaction with ligands is crucial in cancer diagnostics and therapeutics. Here we reported the enhanced phase contrast image of FR by scanning with properly functionalized atomic force microscope (AFM) tips over live cell lines. The choice of the ligand was made for better interaction of tip with FR, expressed in the cell lines. The selectively enhanced force of interaction at the receptor molecule produced a considerable enhancement in the phase contrast between a receptor site and a nonreceptor site. © 2009 American Institute of Physics.


cited By 11

Cite this Research Publication

C. M. Girish, Binulal, N. S., Anitha, V. C., Nair, S., Ullas Mony, and Prasanth, R., “Atomic force microscopic study of folate receptors in live cells with functionalized tips”, Applied Physics Letters, vol. 95, 2009.