Publication Type:

Journal Article

Source:

Pharmacological Reports, Volume 68, Number 2, p.396 - 403 (2016)

URL:

http://www.sciencedirect.com/science/article/pii/S1734114015003400

Keywords:

Chronic forced swim test, Cytokines, folic acid, Tail suspension test, Venlafaxine

Abstract:

Though venlafaxine is an antidepressant with similar efficacy as selective serotonin receptor inhibitors, dose dependent adverse effects limit its use. Depression is associated with increased levels of pro-inflammatory cytokines. The study investigated the effect of combining low/serotonergic dose of venlafaxine with folic acid in mice exposed to chronic forced swim stress for 21 days during which immobility and swimming time following forced swim test (FST) and immobility time in tail suspension test (TST) were measured every 7th, 14th and 21st day. The serum level of pro-inflammatory cytokines (IL-1β and IL-6) and whole brain levels of monoamines (serotonin, norepinephrine and dopamine) were estimated. An augmentation of antidepressant effect was observed in both forced swim test and tail suspension test following combination of venlafaxine (2 and 4mg/kg) with folic acid (5 and 10mg/kg) after 14 and 21 days of treatment. On brain serotonin level also, a significant augmentation was observed when venlafaxine (4mg/kg) was combined with folic acid (10mg/kg). Further, the combination significantly reversed the elevated levels of serum pro-inflammatory cytokines, IL-1β and IL-6 observed in chronic FST-induced stressed mice. Combining low dose venlafaxine with an augmenting agent like folic acid, thus, appears to be an optimum strategy to increase its therapeutic efficacy and to reduce its dose.

Cite this Research Publication

J. Thomas, Khanam, R., and Vohora, D., “Augmentation of Effect of Venlafaxine by Folic Acid in Behavioral Paradigms of Depression in Mice: Evidence of Serotonergic and Pro-Inflammatory Cytokine Pathways”, Pharmacological Reports, vol. 68, pp. 396 - 403, 2016.

207
PROGRAMS
OFFERED
6
AMRITA
CAMPUSES
15
CONSTITUENT
SCHOOLS
A
GRADE BY
NAAC, MHRD
8th
RANK(INDIA):
NIRF 2018
150+
INTERNATIONAL
PARTNERS
  • Amrita on Social Media

  • Contact us

    Amrita Vishwa Vidyapeetham
    Amritanagar, Coimbatore - 641 112
    Tamilnadu, India
    • Fax: +91-422-2686274
    • Coimbatore : +91 (422) 2685000
    • Amritapuri   : +91 (476) 280 1280
    • Bengaluru    : +91 (080) 251 83700
    • Kochi              : +91 (484) 280 1234
    • Mysuru          : +91 (821) 234 3479
    • Contact Details »