Autism spectrum disorders: Integration of the genome, transcriptome and the environment
Publication Type:Journal Article
Source:Journal of the Neurological Sciences, Elsevier, Volume 364, p.167-176 (2016)
Autism spectrum disorders denote a series of lifelong neurodevelopmental conditions characterized by an impaired social communication profile and often repetitive, stereotyped behavior. Recent years have seen the complex genetic architecture of the disease being progressively unraveled with advancements in gene finding technology and next generation sequencing methods. However, a complete elucidation of the molecular mechanisms behind autism is necessary for potential diagnostic and therapeutic applications. A multidisciplinary approach should be adopted where the focus is not only on the 'genetics' of autism but also on the combinational roles of epigenetics, transcriptomics, immune system disruption and environmental factors that could all influence the etiopathogenesis of the disease. ASD is a clinically heterogeneous disorder with great genetic complexity; only through an integrated multidimensional effort can modern autism research progress further. © 2016 Elsevier B.V. All rights reserved.
cited By 0
Cite this Research Publication
Related Research Publications
- Epigenetics targeted protein-vorinostat nanomedicine inducing apoptosis in heterogeneous population of primary acute myeloid leukemia cells including refractory and relapsed cases
- Prediction of candidate genes for neuropsychiatric disorders using feature-based enrichment
- Constructing a personalized e-learning system for students with autism based on soft semantic web technologies
- Integration of common feature pharmacophore modeling and in vitro study to identify potent AChE inhibitors
- Pancreatitis in Children.