Publication Type:

Journal Article


Carbohydrate Polymers, Volume 92, Number 2, p.1561-1565 (2013)



Acanthaceae, Anti-bacterial activity, Anti-Bacterial Agents, Antibacterial, antiinfective agent, article, Bacteria, Biochemical properties, Biocompatible Materials, biomaterial, Biomaterials, blood clotting, Blood Coagulation, cell proliferation, Cell Survival, cell viability, chemistry, chitosan, Chitosan hydrogel, Chitosan scaffold, Colony forming units, Cytology, drug effect, E. coli, Escherichia coli, fibroblast, Fibroblasts, Haemostatic, Hemigraphis, Hemigraphis alternata, human, Human dermal fibroblasts, Humans, hydrogel, Hydrogels, metabolism, plant extract, Plant Extracts, Platelet activation, porosity, S. aureus, Staphylococcus aureus, thrombocyte activation, Water, Wound healing


In this work, Hemigraphis alternata extract incorporated chitosan scaffold was synthesized and characterized for wound healing. The antibacterial activity of Hemigraphis incorporated chitosan scaffold (HIC) against Escherichia coli and Staphylococcus aureus was evaluated which showed a reduction in total colony forming units by 45-folds toward E. coli and 25-fold against S. aureus respectively. Cell viability studies using Human Dermal Fibroblast cells (HDF) showed 90% viability even at 48 h when compared to the chitosan control. The herbal scaffold made from chitosan was highly haemostatic and antibacterial. The obtained results were in support that the herbal scaffold can be effectively applied for infectious wounds. © 2012 Elsevier Ltd.


cited By 2

Cite this Research Publication

M. Annapoorna, Kumar, P. T. Sudheesh, Lakshman, L. R., Lakshmanan, V. - K., Nair, S. V., and Dr. Jayakumar Rangasamy, “Biochemical properties of Hemigraphis alternata incorporated chitosan hydrogel scaffold”, Carbohydrate Polymers, vol. 92, pp. 1561-1565, 2013.