Publication Type:

Journal Article

Source:

International Journal of Applied Ceramic Technology, Blackwell Publishing Inc, Volume 5, Number 1, p.11–19 (2008)

URL:

http://dx.doi.org/10.1111/j.1744-7402.2008.02191.x

Abstract:

Bone defects due to trauma or disease have led to the need for biomaterials as substitutes for tissue regeneration and repair. Herein, we introduce a porous triphasic ceramic-coated hydroxyapatite scaffold (HASi) for such applications. Interestingly, in the degradation experiments with isotonic buffer, HASi showed a significant release of silica with the disappearance of the tricalcium phosphate phase. Furthermore, the material also exhibited cytocompatibility with cultured bone marrow-derived mesenchymal stem cells of human origin. The material chemistry, together with the favorable cellular characteristics, indicates HASi as a promising candidate for critical-size bony defects, which still remains a formidable clinical challenge in the orthopedic scenario.

Cite this Research Publication

A. John, Dr. Manitha B. Nair, Varma, H. K., Bernhardt, A., and Gelinsky, M., “Biodegradation and Cytocompatibility Studies of a Triphasic Ceramic-Coated Porous Hydroxyapatite for Bone Substitute Applications”, International Journal of Applied Ceramic Technology, vol. 5, pp. 11–19, 2008.

207
PROGRAMS
OFFERED
5
AMRITA
CAMPUSES
15
CONSTITUENT
SCHOOLS
A
GRADE BY
NAAC, MHRD
8th
RANK(INDIA):
NIRF 2018
150+
INTERNATIONAL
PARTNERS
  • Amrita on Social Media

  • Contact us

    Amrita Vishwa Vidyapeetham
    Amritanagar, Coimbatore - 641 112
    Tamilnadu, India
    • Fax: +91-422-2686274
    • Coimbatore : +91 (422) 2685000
    • Amritapuri   : +91 (476) 280 1280
    • Bengaluru    : +91 (080) 251 83700
    • Kochi              : +91 (484) 280 1234
    • Mysuru          : +91 (821) 234 3479
    • Contact Details »