Publication Type:

Journal Article


International Journal of Biological Macromolecules, Elsevier B.V., Volume 110, p.2-6 (2018)



amphotericin B, antibiotic agent, brucellosis, Candidiasis, ceftriaxone, chloroquine, ciprofloxacin, diarrhea, drug carrier, drug delivery system, drug penetration, encephalitis, fungal meningitis, host cell, human, infection, intracellular infection, isoniazid, liposome, macrophage, moxifloxacin, nanocarrier, nonhuman, review, rifabutin, rifampicin, silica nanoparticle, silver nanoparticle, streptomycin, targeted nanodrug delivery system, Tuberculosis, Tularemia


<p>Intracellular infections are tricky to treat, the reason being the poor penetration of antibiotics/antimycotics into the microbial niche (host cell). Macrophages are primary targets of facultative and obligate intracellular bacteria/fungi to be abused as host cells. The need for drugs with better intracellular penetration led to the development of endocytosable drug carriers, which can cross the cell membrane of the host cells (macrophages) by imitating the entry path of the pathogens. Therefore, the drugs can be targeted to macrophages ensuring enhanced therapeutic effect. This review discusses the exploitation of various nanocarriers for targeted delivery of drugs to the macrophages in the last two decades. © 2018 Elsevier B.V.</p>


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Cite this Research Publication

V. Aparna, Shiva, M., Biswas, R., and Jayakumar, R., “Biological macromolecules based targeted nanodrug delivery systems for the treatment of intracellular infections”, International Journal of Biological Macromolecules, vol. 110, pp. 2-6, 2018.