Bone is a natural composite material consisting of an organic phase (collagen) and a mineral phase (calcium phosphate, especially hydroxyapatite). The strength of bone is attributed to the apatite, while the collagen fibrils are responsible for the toughness and visco-elasticity. The challenge in bone tissue engineering is to develop such biomimetic composite scaffolds, having a balance between biological and biomechanical properties. This review summarizes the current state of the field by outlining composite scaffolds made of gelatin/collagen in combination with bioactive ceramics for bone tissue engineering application.
S. Kuttappan, Mathew, D., and Dr. Manitha B. Nair, “Biomimetic composite scaffolds containing bioceramics and collagen/gelatin for bone tissue engineering - A mini review.”, Int J Biol Macromol, vol. 93, no. Pt B, pp. 1390-1401, 2016.