Publication Type:

Journal Article

Source:

Analyst, The Royal Society of Chemistry, Volume 142, Issue 2, p.345-350 (2017)

URL:

http://dx.doi.org/10.1039/C6AN02107G

Abstract:

We developed a nitroreductase responsive theranostic probe 1; it comprises biotinylated rhodol in conjunction with p-nitrobenzyl functionality. The probe 1 showed a remarkable fluorescence {'}turn-on{'} signal in the presence of nitroreductase under physiological conditions. The probe is considerably stable within a wide biological pH range (6-8) and also is very sensitive toward a reducing micro-environment e.g. liver microsome. Further{,} it enables providing cellular and in vivo nematode images in a reducing microenvironment.

Cite this Research Publication

Y. Zhou, Bobba, K. Naidu, Lv, X. Wei, Yang, D., Velusamy, N., Zhang, J. Feng, and Bhuniya, S., “A biotinylated piperazine-rhodol derivative: a 'turn-on' probe for nitroreductase triggered hypoxia imaging”, Analyst, vol. 142, no. 2, pp. 345-350, 2017.