Publication Type:

Journal Article

Source:

Analyst, Royal Society of Chemistry, Volume 142, Number 2, p.345-350 (2017)

URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010424636&doi=10.1039%2fc6an02107g&partnerID=40&md5=655fdcb826ec9a097f8381a94b20778c

Abstract:

<p>We developed a nitroreductase responsive theranostic probe 1; it comprises biotinylated rhodol in conjunction with p-nitrobenzyl functionality. The probe 1 showed a remarkable fluorescence 'turn-on' signal in the presence of nitroreductase under physiological conditions. The probe is considerably stable within a wide biological pH range (6-8) and also is very sensitive toward a reducing micro-environment e.g. liver microsome. Further, it enables providing cellular and in vivo nematode images in a reducing microenvironment. © The Royal Society of Chemistry 2017.</p>

Notes:

cited By 1

Cite this Research Publication

Ya Zhou, Bobba, K. Nb, Lv, X. Wa, Yang, Da, Velusamy, Nb, Zhang, J. Fc, and Bhuniya, S., “A biotinylated piperazine-rhodol derivative: A 'turn-on' probe for nitroreductase triggered hypoxia imaging”, Analyst, vol. 142, pp. 345-350, 2017.

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