<p>We developed a nitroreductase responsive theranostic probe 1; it comprises biotinylated rhodol in conjunction with p-nitrobenzyl functionality. The probe 1 showed a remarkable fluorescence 'turn-on' signal in the presence of nitroreductase under physiological conditions. The probe is considerably stable within a wide biological pH range (6-8) and also is very sensitive toward a reducing micro-environment e.g. liver microsome. Further, it enables providing cellular and in vivo nematode images in a reducing microenvironment. © The Royal Society of Chemistry 2017.</p>
cited By 1
Ya Zhou, Bobba, K. Nb, Lv, X. Wa, Yang, Da, Velusamy, Nb, Zhang, J. Fc, and Bhuniya, S., “A biotinylated piperazine-rhodol derivative: A 'turn-on' probe for nitroreductase triggered hypoxia imaging”, Analyst, vol. 142, pp. 345-350, 2017.